Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 542284
Title A Plausible Microtubule-Based Mechanism for Cell Division Orientation in Plant Embryogenesis
Author(s) Chakrabortty, Bandan; Willemsen, Viola; Zeeuw, Thijs de; Liao, Che Yang; Weijers, Dolf; Mulder, Bela; Scheres, Ben
Source Current Biology 28 (2018)19. - ISSN 0960-9822 - p. 3031 - 3043.e2.
DOI https://doi.org/10.1016/j.cub.2018.07.025
Department(s) Plant Developmental Biology
Laboratory of Molecular Biology
EPS
Biochemistry
Laboratory of Cell Biology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) arabidopsis - auxin - cell shape - computational modeling - cytokinesis - division orientation - embryogenesis - microtubules - systems biology
Abstract

Oriented cell divisions are significant in plant morphogenesis because plant cells are embedded in cell walls and cannot relocate. Cell divisions follow various regular orientations, but the underlying mechanisms have not been clarified. We propose that cell-shape-dependent self-organization of cortical microtubule arrays is able to provide a mechanism for determining planes of early tissue-generating divisions and may form the basis for robust control of cell division orientation in the embryo. To show this, we simulate microtubules on actual cell surface shapes, from which we derive a minimal set of three rules for proper array orientation. The first rule captures the effects of cell shape alone on microtubule organization, the second rule describes the regulation of microtubule stability at cell edges, and the third rule includes the differential effect of auxin on local microtubule stability. These rules generate early embryonic division plane orientations and potentially offer a framework for understanding patterned cell divisions in plant morphogenesis. Chakrabortty et al. show that a computational model for dynamic self-organization of cortical microtubules on experimentally extracted cell shapes provides a plausible molecular mechanism for division plane orientation in the first four divisions of early stage A. thaliana embryos, in WT as well as two developmental mutants bodenlos and clasp.

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