Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 543797
Title A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics
Author(s) Rooij, Myrna M.T. de; Leuken, Jeroen P.G. van; Swart, Arno; Kretzschmar, Mirjam E.E.; Nielen, Mirjam; Koeijer, Aline A. de; Janse, Ingmar; Wouters, Inge M.; Heederik, Dick J.J.
Source Zoonoses and Public Health (2018). - ISSN 1863-1959
DOI https://doi.org/10.1111/zph.12534
Department(s) CVI Bacteriology and Epidemiology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) airborne exposure - Coxiella burnetii - epidemiology - Q fever - risk assessment - spatial analysis
Abstract

From 2007 through 2010, the Netherlands experienced the largest Q fever epidemic ever reported. This study integrates the outcomes of a multidisciplinary research programme on spatial airborne transmission of Coxiella burnetii and reflects these outcomes in relation to other scientific Q fever studies worldwide. We have identified lessons learned and remaining knowledge gaps. This synthesis was structured according to the four steps of quantitative microbial risk assessment (QMRA): (a) Rapid source identification was improved by newly developed techniques using mathematical disease modelling; (b) source characterization efforts improved knowledge but did not provide accurate C. burnetii emission patterns; (c) ambient air sampling, dispersion and spatial modelling promoted exposure assessment; and (d) risk characterization was enabled by applying refined dose–response analyses. The results may support proper and timely risk assessment and risk management during future outbreaks, provided that accurate and structured data are available and exchanged readily between responsible actors.

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