Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 544575
Title Leydig Cells
Author(s) Huhtaniemi, I.; Teerds, K.J.
Source In: Encyclopedia of Reproduction / Skinner, M.K., Academic Press Elsevier - ISBN 9780128118993 - p. 30 - 38.
DOI https://doi.org/10.1016/B978-0-12-801238-3.64558-0
Department(s) WIAS
VLAG
Human and Animal Physiology
Publication type Chapter in scientific book
Publication year 2018
Abstract Leydig cells (LC) are present in the testicular interstitial tissue, and their main function is to produce testosterone (T) for the maintenance of spermatogenesis and extratesticular androgenic and anabolic functions. LC appear in fetal life, and their hormonal products (T and INSL3) direct male fetal masculinization and early development of genital structures. After the quiescent phase between birth and puberty another adult LC population appears and persists until old age. Their T production is the key hormonal stimulus of the male phenotype. We will review here the development, function, regulation, as well as key pathophysiological aspects of the LC.
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