Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 545410
Title Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats
Author(s) Baliu-Piqué, Mariona; Kurniawan, Henry; Ravesloot, Lars; Verheij, Myrddin W.; Drylewicz, Julia; Lievaart-Peterson, Karianne; Borghans, José A.M.; Koets, Ad; Tesselaar, Kiki
Source Developmental and Comparative Immunology 93 (2019). - ISSN 0145-305X - p. 1 - 10.
DOI https://doi.org/10.1016/j.dci.2018.12.004
Department(s) CVI Bacteriology and Epidemiology
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Deuterium - Development - Goat - Mathematical modelling - Neonatal adaptive immunity - Stable isotope labelling - T-cell turnover - T-lymphocytes
Abstract

Neonatal mammals have increased disease susceptibility and sub-optimal vaccine responses. This raises problems in both humans and farm animals. The high prevalence of paratuberculosis in goats and the lack of an effective vaccine against it have a strong impact on the dairy sector, and calls for vaccines optimized for the neonatal immune system. We characterized the composition of the T-cell pool in neonatal kids and adult goats and quantified their turnover rates using in vivo deuterium labelling. From birth to adulthood, CD4+ T-cells were the predominant subset in the thymus and lymph nodes, while spleen and bone marrow contained mainly CD8+ lymphocytes. In blood, CD4+ T-cells were the predominant subset during the neonatal period, while CD8+ T-cells predominated in adults. We observed that thymic mass and cellularity increased during the first 5 months after birth, but decreased later in life. Deuterium labelling revealed that T-cell turnover rates in neonatal kids are considerably higher than in adult animals.

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