Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 552556
Title Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia l.
Author(s) Ernst, Madeleine; Nothias, Louis Félix; Hooft, Justin J.J. van der; Silva, Ricardo R.; Saslis-Lagoudakis, Haris C.; Grace, Olwen M.; Martinez-Swatson, Karen; Hassemer, Gustavo; Funez, Luís A.; Simonsen, Henrik T.; Medema, Marnix H.; Staerk, Dan; Nilsson, Niclas; Lovato, Paola; Dorrestein, Pieter C.; Rønsted, Nina
Source Frontiers in Plant Science 10 (2019). - ISSN 1664-462X
DOI https://doi.org/10.3389/fpls.2019.00846
Department(s) Bioinformatics
EPS
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Coevolution - Computational metabolomics - Euphorbia - Immunomodulatory testing - Specialized metabolites
Abstract

Coevolutionary theory suggests that an arms race between plants and herbivores yields increased plant specialized metabolite diversity and the geographic mosaic theory of coevolution predicts that coevolutionary interactions vary across geographic scales. Consequently, plant specialized metabolite diversity is expected to be highest in coevolutionary hotspots, geographic regions, which exhibit strong reciprocal selection on the interacting species. Despite being well-established theoretical frameworks, technical limitations have precluded rigorous hypothesis testing. Here we aim at understanding how geographic separation over evolutionary time may have impacted chemical differentiation in the cosmopolitan plant genus Euphorbia. We use a combination of state-of-the-art computational mass spectral metabolomics tools together with cell-based high-throughput immunomodulatory testing. Our results show significant differences in specialized metabolite diversity across geographically separated phylogenetic clades. Chemical structural diversity of the highly toxic Euphorbia diterpenoids is significantly reduced in species native to the Americas, compared to Afro-Eurasia. The localization of these compounds to young stems and roots suggest a possible ecological relevance in herbivory defense. This is further supported by reduced immunomodulatory activity in the American subclade as well as herbivore distribution patterns. We conclude that computational mass spectrometric metabolomics coupled with relevant ecological data provide a strong tool for exploring plant specialized metabolite diversity in a chemo-evolutionary framework.

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