Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 63135
Title Utilisation of genetic variation by marker assisted selection in commercial dairy cattle populations
Author(s) Spelman, R.J.; Garrick, D.J.; Arendonk, J.A.M. van
Source Livestock Production Science 59 (1999)1. - ISSN 0301-6226 - p. 51 - 60.
Department(s) Animal Breeding and Genetics
Publication type Refereed Article in a scientific journal
Publication year 1999
Abstract Potential genetic benefits of marker assisted selection (MAS) were evaluated by calculating selection response resulting from four pathways of selection. Genetic variation was partitioned into polygenic and loci that were in linkage disequilibrium with marker loci or haplotypes. The percentage of genetic variation that was marked was varied from 0 to 100%. These assumptions describe the degree of genetic knowledge that may be available in 10 years. Three breeding strategies with markers were evaluated: progeny test scheme (BMARK); progeny test scheme but unproven bulls allowed on the bull to bull selection path (YBULL); and a breeding programme where cows without lactation information and bulls without progeny information were eligible for selection (OPEN). Rates of genetic gain (per year) with no marked genetic variance were 0.26 σ(G) for the BMARK and YBULL schemes and 0.28 σ(G) for the OPEN scheme. On average, an increase of 1% marked genetic variance resulted in an increase in genetic gain of ~0.25% for the BMARK scheme, 0.5% for the YBULL scheme and 1% for the OPEN scheme. Maximum genetic response (100% marked genetic variance) for the BMARK scheme was 1.24 times that achieved with no marked genetic variance, 1.52 times for the YBULL scheme, and 2.05 times for the OPEN scheme. Changes in the structure of the breeding scheme are needed to fully gain the benefits of identified loci especially for medium to large proportions of marked genetic variance.
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