Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 63950
Title Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease
Author(s) Bemelmans, W.J.E.; Muskiet, F.A.J.; Feskens, E.J.M.; Vries, F.H.M. de; May, J.F.; Meyboom-de Jong, B.
Source European Journal of Clinical Nutrition 54 (2000). - ISSN 0954-3007 - p. 865 - 871.
Department(s) Human Nutrition (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2000
Abstract Background: Prevention of coronary heart disease (CHD) in high-risk subjects. Objective: To investigate the associations of dietary intake of alpha-linolenic acid (ALA) and linoleic acid (LA) as assessed by food frequency questionnaire and in the plasma cholesteryl ester (CE), with CHD risk factors. Design: Baseline data of a double-blind, randomized placebo-controlled trial. Subjects have hypercholesterolemia (6.0-8.0 mmol/l) and at least two other CHD risk factors (n=266). Results: The reported dietary ALA and LA intakes and the LA/ALA ratio were associated with the contents in the CE (r=0.37, r=0.21, and r=0.42, respectively; P<0.01). In multivariate analysis, CE ALA was inversely associated with diastolic blood pressure (r=-0.13; P<0.05) and positively with serum triacylglycerol (r=0.13; P<0.05), and CE LA was inversely associated with serum triacylglycerol (r=-0.32; P<0.01). The CE LA/ALA ratio was strongly inversely associated with CE ALA (r=-0.95; P<0.01). In the lowest quintile of CE ALA, mean dietary intake was 0.4 energyLA (1.2 g/day), 8.4 energy ␕A and an LA/ALA ratio of 21, and in the highest quintile 0.6 energyLA (1.7 g/day), 6.8 energy ␕A and 12 (ratio). In the lowest quintile of CE ALA the diastolic blood pressure was 4 mmHg lower (P trend<0.05), and the serum triacylglycerol 0.3 mmol/l higher (P trend NS) when compared with the top quintile. Conclusions: In a CHD high-risk population with LA-rich background diet, these cross-sectional data suggest that replacing LA in the diet by ALA may decrease diastolic blood pressure, and may increase serum triacylglycerol concentration.
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