Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 64051
Title UVB irradiation modulates systemic immune responses by affecting cytokine production of antigen-presenting cells
Author(s) Boonstra, A.; Oudenaren, A. van; Barendregt, B.; An, L.; Leenen, P.J.; Savelkoul, H.F.J.
Source International immunology 12 (2000). - ISSN 0953-8178 - p. 1531 - 1538.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2000
Abstract The immunosuppressive effects of UVB irradiation have been well documented. The production of cytokines by keratinocytes is considered to play a major role in the induction of local as well as systemic immunosuppression. It is thought that partly due to the interaction of locally produced cytokines with antigen-presenting cells (APC) systemic effects, like antigen-specific tolerance, can be induced. In this study we examined the effect of UVB irradiation on cytokine profiles of peripheral APC as well as the functional consequences. Our results indicate that UVB irradiation impairs Th1-mediated immune responses in vivo by suppression of the systemic IL-12p70 production. Splenic APC from UVB-exposed mice showed an enhanced production of prostaglandin E2, IL-1, IL-6 and tumor necrosis factor- after in vitro stimulation. Also, spleen cells from UVB irradiated IL-4–/– mice showed increased IL-6 levels. These APC were less efficient in inducing IFN- production by CD4 T cells and suppressed IgM production by B cells. We conclude that the altered cytokine profile of peripheral APC can be responsible for the systemic effects of UVB irradiation on the Th1/Th2 balance as well as on B cell responses
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