Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 65653
Title A germline homozygote deletion of the glutathione-s-transferase Mu 1 gene predisposes to bladder cancer
Author(s) Mungan, N.A.; Aben, K.K.H.; Beeks, E.; Kampman, E.; Bunschoten, A.; Bussemakers, M.; Witjes, J.A.
Source Urologia internationalis 64 (2000). - ISSN 0042-1138 - p. 134 - 138.
Department(s) Human Nutrition (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2000
Abstract Introduction and Objectives: Numerous studies have shown smoking and specific occupational exposures to be risk factors for bladder cancer. The risk of bladder cancer may be modified by the activity of carcinogen metabolizing enzymes. The glutathione-S-transferase Mu1 enzyme (GSTM1) detoxifies arylepoxides which are formed after exposure to certain polycyclic aromatic hydrocarbons and possibly aromatic amines. Approximately 40 f Caucasians lack GSTM1 activity due to a homozygous deletion of the GSTM1 locus on chromosome 1p13 (GSTM1 0/0 genotype). The aim of this study was to evaluate the combined effect of smoking and GSTM1 genotype on the risk of bladder cancer. Materials and Methods: Sixty-one patients with transitional cell carcinoma of the bladder and 69 controls matched for age and sex were enrolled from the outpatient clinic. Lifestyle information was collected with a standardized questionnaire. DNA was extracted from white blood cells. The GSTM1 genotype was determined by a PCR-based method. Results: 92 f the 61 patients had a history of smoking compared with 81 f the controls. There was a significant dose-response relationship for pack-years of smoking (trend test: p = 0.003). The proportion of GSTM1 0/0 genotype among patients was 62␌ompared with 43 mong controls (odds ratio = 2.1; 95␌I 1.1-4.3). The expected interaction between smoking and GSTM1 genotype was not observed. Conclusions: This study confirms the findings that a germline homozygous deletion of the GSTM1 gene predisposes to bladder cancer. An interaction with smoking was not found.
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