Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance
Brouwer, E.M. ; Brennan, L. ; Drevon, C.A. ; Kranen, H. van; Feskens, E.J.M. - \ 2017
Proceedings of the Nutrition Society 76 (2017)4. - ISSN 0029-6651 - p. 619 - 627.
FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food intake biomarker research and highlights present research efforts of the Joint Programming Initiative ‘A Healthy Diet for a Healthy Life’ (JPI-HDHL) Food Biomarkers Alliance (FoodBAll). In order to identify novel food intake biomarkers, the focus is on new food metabolomics techniques that allow the quantification of up to thousands of metabolites simultaneously, which may be applied in intervention and observational studies. As biomarkers are often influenced by various other factors than the food under investigation, FoodBAll developed a food intake biomarker quality and validity score aiming to assist the systematic evaluation of novel biomarkers. Moreover, to evaluate the applicability of nutritional biomarkers, studies are presently also focusing on associations between food intake biomarkers and diet-related disease risk. In order to be successful in these metabolomics studies, knowledge about available electronic metabolomics resources is necessary and further developments of these resources are essential. Ultimately, present efforts in this research area aim to advance quality control of traditional dietary assessment methods, advance compliance evaluation in nutritional intervention studies, and increase the significance of observational studies by investigating associations between nutrition and health.
Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life.
Kaput, J. ; Ommen, B. van; Kremer, B. ; Priami, C. ; Pontes Monteiro, J. ; Morine, M. ; Pepping, F. ; Diaz, Z. ; Fenech, M. ; He, Y. ; Albers, R. ; Drevon, C.A. ; Evelo, C.T. ; Hancock, R.E.W. ; Ijsselmuiden, C. ; Lumey, L.H. ; Minihane, A.M. ; Muller, M.R. ; Murgia, C. ; Radonjic, M. ; Sobral, B.W.S. ; West Jr., K.P. - \ 2014
Genes & Nutrition 9 (2014)9. - ISSN 1555-8932 - 9 p.
birth-weight infants - developing-countries - global health - environmental enteropathy - participatory research - grand challenges - innate immunity - trace-elements - biology - nutrition
Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems’ responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.
Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies
Ommen, B. van; Bouwman, J.H. ; Dragsted, L.O. ; Drevon, C.A. ; Elliott, R. ; Groot, P.J. de; Kaput, J. ; Mathers, J.C. ; Müller, M.R. ; Pepping, F. ; Saito, J. ; Scalbert, A. ; Radonjic, M. ; Rocca-Serra, P. ; Travis, A. ; Wopereis, S. ; Evelo, C. - \ 2010
Genes & Nutrition 5 (2010)3. - ISSN 1555-8932 - p. 189 - 203.
gene-expression - metabolic phenotypes - association - framework - services - network - complex - health - diet
The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network of interacting processes. Whereas nutrition research can profit enormously from the revolution in ‘omics’ technologies, it has discipline-specific requirements for analytical and bioinformatic procedures. In addition to measurements of the parameters of interest (measures of health), extensive description of the subjects of study and foods or diets consumed is central for describing the nutritional phenotype. We propose and pursue an infrastructural activity of constructing the “Nutritional Phenotype database” (dbNP). When fully developed, dbNP will be a research and collaboration tool and a publicly available data and knowledge repository. Creation and implementation of the dbNP will maximize benefits to the research community by enabling integration and interrogation of data from multiple studies, from different research groups, different countries and different-omics levels. The dbNP is designed to facilitate storage of biologically relevant, pre-processed-omics data, as well as study descriptive and study participant phenotype data. It is also important to enable the combination of this information at different levels (e.g. to facilitate linkage of data describing participant phenotype, genotype and food intake with information on study design and-omics measurements, and to combine all of this with existing knowledge). The biological information stored in the database (i.e. genetics, transcriptomics, proteomics, biomarkers, metabolomics, functional assays, food intake and food composition) is tailored to nutrition research and embedded in an environment of standard procedures and protocols, annotations, modular data-basing, networking and integrated bioinformatics. The dbNP is an evolving enterprise, which is only sustainable if it is accepted and adopted by the wider nutrition and health research community as an open source, pre-competitive and publicly available resource where many partners both can contribute and profit from its developments. We introduce the Nutrigenomics Organisation (NuGO, as a membership association responsible for establishing and curating the dbNP. Within NuGO, all efforts related to dbNP (i.e. usage, coordination, integration, facilitation and maintenance) will be directed towards a sustainable and federated infrastructure
A Combined Transcriptomics and Lipidomics Analysis of Subcutaneous, Epididymal and Mesenteric Adipose Tissue Reveals Marked Functional Differences
Caesar, R. ; Manieri, M. ; Kelder, T. ; Boekschoten, M.V. ; Evelo, C. ; Müller, M.R. ; Kooistra, T. ; Cinti, S. ; Kleemann, R. ; Drevon, C.A. - \ 2010
PLoS ONE 5 (2010)7. - ISSN 1932-6203 - 14 p.
element-binding protein - messenger-rna expression - fatty-acid-composition - gene-expression - lymphoid-cells - insulin sensitivity - human preadipocytes - glucose-metabolism - obese subjects - in-vitro
Depot-dependent differences in adipose tissue physiology may reflect specialized functions and local interactions between adipocytes and surrounding tissues. We combined time-resolved microarray analyses of mesenteric- (MWAT), subcutaneous- (SWAT) and epididymal adipose tissue (EWAT) during high-fat feeding of male transgenic ApoE3Leiden mice with histology, targeted lipidomics and biochemical analyses of metabolic pathways to identify differentially regulated processes and site-specific functions. EWAT was found to exhibit physiological zonation. De novo lipogenesis in fat proximal to epididymis was stably low, whereas de novo lipogenesis distal to epididymis and at other locations was down-regulated in response to high-fat diet. The contents of linoleic acid and a-linolenic acid in EWAT were increased compared to other depots. Expression of the androgen receptor (Ar) was higher in EWAT than in MWAT and SWAT. We suggest that Ar may mediate depot-dependent differences in de novo lipogenesis rate and propose that accumulation of linoleic acid and a-linolenic acid in EWAT is favored by testosterone-mediated inhibition of de novo lipogenesis and may promote further elongation and desaturation of these polyunsaturated fatty acids during spermatogenesis
Association of 1-y changes in diet pattern with cardiovascular disease risk factors and adipokines: results from the 1-y randomized Oslo Diet and Exercise Study
Jacobs, D.R. ; Sluik, D. ; Rokling-Andersen, M.H. ; Anderssen, S.A. ; Drevon, C.A. - \ 2009
American Journal of Clinical Nutrition 89 (2009)2. - ISSN 0002-9165 - p. 509 - 517.
insulin-resistance - atherosclerosis mesa - adipose-tissue - inflammation - markers - food - intervention - carbohydrate - obesity - women
Background: We hypothesized that favorable changes in dietary patterns would lead to a reduction in body size and an improvement in metabolic status. Objective: The objective was to study changes in diet patterns relative to changes in body size, blood pressure, and circulating concentrations of lipids, glucose, insulin, adiponectin, and other cytokines in the context of a 1-y randomized intervention study. Design: For 1 y, 187 men aged 45 +/- 2 y, approximate to 50% of whom met the criteria of the metabolic syndrome, were randomly assigned to a diet protocol (n = 45), an exercise protocol (n = 48), a protocol of diet plus exercise (n = 58), or a control protocol (n = 36). A previously defined a priori diet score was created by summing tertile rankings of 35 food group variables; a higher score generally reflected recommended dietary changes in the trial (mean +/- SD at baseline: 31 +/- 6.5; range: 15-47). Results: Over the study year, the diet score increased by approximate to 2 +/- 5.5 in both diet groups, with a decrease of an equivalent amount in the exercise and control groups. The weight change was 23.5 +/- 0.6 kg/10-point change in diet score (P <0.0001), similarly within each intervention group, independently of the change in energy intake or baseline age and smoking status. Weight change was attenuated but remained significant after adjustment for intervention group and percentage body fat. Subjects with an increased diet score had more favorable changes in other body size variables, systolic blood pressure, and blood lipid, glucose, insulin, and adiponectin concentrations. Change in diet score was unrelated to resistin and several cytokines. Conclusion: The change toward a more favorable diet pattern was associated with improved body size and metabolic profile. Am J Clin Nutr 2009; 89: 509-17.
The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Oganisation
Baccini, M. ; Bachmaier, E.M. ; Biggeri, A. ; Boekschoten, M.V. ; Bouwman, F.G. ; Brennan, L. ; Caesar, R. ; Cinti, S. ; Coort, S.L. ; Crosley, K. ; Daniel, H. ; Drevon, C.A. ; Duthie, S. ; Eijssen, L. ; Elliott, R. ; Erk, M.J. van; Evelo, C. ; Gibney, M.J. ; Heim, C. ; Horgan, G. ; Johnson, I.T. ; Kelder, T. ; Kleemann, R. ; Kooistra, T. ; Iersel, M.P. van; Mariman, E.C.M. ; Mayer, C. ; McLoughlin, G. ; Müller, M.R. ; Mulholland, F. ; Ommen, B. van; Polley, A.C. ; Pujos-Guillot, E. ; Rubio-Aliaga, I. ; Roche, H. ; Roos, B. de; Sailer, M. ; Tonini, G. ; Williams, L.M. ; Wit, N.J.W. de - \ 2008
Genes & Nutrition 3 (2008)3. - ISSN 1555-8932 - p. 147 - 151.
The challenges for molecular nutrition research 2: quantification of the nutritional phenotype
Ommen, B. van; Keijer, J. ; Kleemann, R. ; Elliott, R. ; Drevon, C.A. ; McArdle, H. ; Gibney, M.J. ; Müller, M.R. - \ 2008
Genes & Nutrition 3 (2008)2. - ISSN 1555-8932 - p. 51 - 59.
c-reactive protein - gene-expression profiles - blood mononuclear-cells - in-vivo - cardiovascular-disease - developmental origins - healthy-volunteers - metabolic syndrome - body-temperature - systems biology
In quantifying the beneficial effect of dietary interventions in healthy subjects, nutrition research meets a number of new challenges. Inter individual variation in biomarker values often is larger than the effect related to the intervention. Healthy subjects have a remarkable capacity to maintain homeostasis, both through direct metabolic regulation, metabolic compensation of altered diets, and effective defence and repair mechanisms in oxidative and inflammatory stress. Processes involved in these regulatory activities essentially different from processes involved in early onset of diet related diseases. So, new concepts and approaches are needed to better quantify the subtle effects possibly achieved by dietary interventions in healthy subjects. Apart from quantification of the genotype and food intake (these are discussed in separate reviews in this series), four major areas of innovation are discussed: the biomarker profile concept, perturbation of homeostasis combined with omics analysis, imaging, modelling and fluxes. All of these areas contribute to a better understanding and quantification of the nutritional phenotype.
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