Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Alcohol and red wine consumption, but not fruit, vegetables, fish or dairy products, are associated with less endothelial dysfunction and less low-grade inflammation : the Hoorn Study
Bussel, B.C.T. van; Henry, R.M.A. ; Schalkwijk, C.G. ; Dekker, J.M. ; Nijpels, G. ; Feskens, E.J.M. ; Stehouwer, C.D.A. - \ 2018
European Journal of Nutrition 57 (2018)4. - ISSN 1436-6207 - p. 1409 - 1419.
Diet - Elderly - Endothelial dysfunction - Inflammation - Red wine
Purpose: Endothelial dysfunction and low-grade inflammation are key phenomena in the pathobiology of cardiovascular disease (CVD). Their dietary modification might explain the observed reduction in CVD that has been associated with a healthy diet rich in fruit, vegetables and fish, low in dairy products and with moderate alcohol and red wine consumption. We investigated the associations between the above food groups and endothelial dysfunction and low-grade inflammation in a population-based cohort of Dutch elderly individuals. Methods: Diet was measured by food frequency questionnaire (n = 801; women = 399; age 68.5 ± 7.2 years). Endothelial dysfunction was determined (1) by combining von Willebrand factor, and soluble intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1, endothelial selectin and thrombomodulin, using Z-scores, into a biomarker score and (2) by flow-mediated vasodilation (FMD), and low-grade inflammation by combining C-reactive protein, serum amyloid A, interleukin 6, interleukin 8, tumour necrosis factor α and sICAM-1 into a biomarker score, with smaller FMD and higher scores representing more dysfunction and inflammation, respectively. We used linear regression analyses to adjust associations for sex, age, energy, glucose metabolism, body mass index, smoking, prior CVD, educational level, physical activity and each of the other food groups. Results: Moderate [β (95% CI) −0.13 (−0.33; 0.07)] and high [−0.22 (−0.45; −0.003)] alcohol consumption, and red wine [−0.16 (−0.30; −0.01)] consumption, but none of the other food groups, were associated with a lower endothelial dysfunction biomarker score and a greater FMD. The associations for FMD were, however, not statistically significant. Only red wine consumption was associated with a lower low-grade inflammation biomarker score [−0.18 (−0.33; −0.04)]. Conclusions: Alcohol and red wine consumption may favourably influence processes involved in atherothrombosis.
Adapted dietary inflammatory index and its association with a summary score for low-grade inflammation and markers of glucose metabolism: the Cohort study on Diabetes and Atherosclerosis Maastricht (CODAM) and the Hoorn study
Woudenbergh, G.J. van; Theofylaktopoulou, D. ; Kuijsten, A. ; Ferreira, I. ; Greevenbroek, M.M. ; Kallen, C.J.H. van der; Schalkwijk, C.G. ; Stehouwer, C.D.A. ; Ocké, M.C. ; Nijpels, G. ; Dekker, J.M. ; Blaak, E.E. ; Feskens, E.J.M. - \ 2013
American Journal of Clinical Nutrition 98 (2013)5. - ISSN 0002-9165 - p. 1533 - 1542.
endothelial dysfunction - insulin-resistance - relative validity - population - risk - metaanalysis - fat - reproducibility - questionnaire - determinants
Background: Diet may be associated with the development of type 2 diabetes through its effects on low-grade inflammation. Objectives: We investigated whether an adapted dietary inflammatory index (ADII) is associated with a summary score for low-grade inflammation and markers of glucose metabolism. In addition, we investigated the mediating role of inflammation in the association between ADII and markers of glucose metabolism. Design: We performed cross-sectional analyses of 2 Dutch cohort studies (n= 1024). An ADII was obtained by multiplying standardized energy-adjusted intakes of dietary components by literature-based dietary inflammatory weights that reflected the inflammatory potential of components. Subsequently, these multiplications were summed. Six biomarkers of inflammation were compiled in a summary score. Associations of the ADII (expressed per SD) with the summary score for inflammation and markers of glucose metabolism were investigated by using multiple linear regression models. Inflammation was considered a potential mediator in the analysis with markers of glucose metabolism. Results: A higher ADII was associated with a higher summary score for inflammation [beta-adjusted = 0.04 per SD (95% CI: 0.01, 0.07 per SD)]. The ADII was, also adversely associated with insulin resistance [homeostatic model assessment of insulin resistance (HOMA-IR): beta-adjusted = 3.5% per SD (95% CI: 0.6%, 6.-3% per SD)]. This association was attenuated after the inclusion of the summary score for inflammation [beta-adjusted+inflammation = 2.2% (95% CI: -0.6%, 5.0%)]. The ADII was also adversely associated with fasting glucose and postload glucose but not with glycated hemoglobin. Conclusion: The significant mediating role of low-grade inflammation in the association between the ADII and HOMA-IR suggests that inflammation might be one of the pathways through which diet affects insulin resistance.
Dairy intake in relation to cardiovascular disease mortality and all-cause mortality: the Hoorn study
Aerde, M.A. van; Soedamah-Muthu, S.S. ; Geleijnse, J.M. ; Snijder, M.B. ; Nijpels, G. ; Stehouwer, C.D.A. ; Dekker, J.M. - \ 2013
European Journal of Nutrition 52 (2013)2. - ISSN 1436-6207 - p. 609 - 616.
coronary-heart-disease - dietary-intake - blood-pressure - calcium intake - milk drinking - reduced risk - skim milk - vitamin-d - consumption - cohort
Purpose Existing data from prospective cohort studies on dairy consumption and cardiovascular diseases are inconsistent. Even though the association between total dairy and cardiovascular diseases has been studied before, little is known about the effect of different types of dairy products on cardiovascular diseases (CVD). The objective of this study was to examine the relationship between (type of) dairy intake and CVD mortality and all-cause mortality in a Dutch population. Methods We examined the relationship between dairy intake and CVD mortality and all-cause mortality in 1956 participants of the Hoorn Study (aged 50–75 years), free of CVD at baseline. Hazard ratios with 95 % CIs were obtained for CVD mortality and all-cause mortality per standard deviation (SD) of the mean increase in dairy intake, with adjustment for age, sex, BMI, smoking, education, total energy intake, alcohol consumption, physical activity, and dietary intakes. Results During 12.4 years of follow-up, 403 participants died, of whom 116 had a fatal CVD event. Overall dairy intake was not associated with CVD mortality or all-cause mortality. Each SD increase in high-fat dairy intake was associated with a 32 % higher risk of CVD mortality (95 % CI; 7–61 %). Conclusion In this prospective cohort study, the intake of high-fat dairy products was associated with an increased risk of CVD mortality
The association between the -374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies
Engelen, L. ; Ferreira, I. ; Gaens, K.H. ; Henry, R. ; Dekker, J.M. ; Nijpels, G. ; Heine, R.J. ; Hart, L.M. t; Greevenboek, M.M. van; Kallen, C.J. ; Blaak, E.E. ; Feskens, E.J.M. ; Cate, H. ten; Stehouwer, C.D. ; Schalkwijk, C.G. - \ 2010
Journal of Hypertension 28 (2010)2. - ISSN 0263-6352 - p. 285 - 293.
type-1 diabetic-patients - end-products gene - rage gly82ser polymorphism - cardiovascular-disease - risk-factors - korean population - heart-disease - retinopathy - complications - nephropathy
Objectives: Receptor for advanced glycation endproducts (RAGE)–ligand interaction may lead to vascular complications. Genetic variation in RAGE has been shown to alter expression, activity of RAGE or both. We, therefore, investigated whether RAGE single-nucleotide polymorphisms (SNPs) and haplotypes were associated with vascular disease. Methods: Nine tag SNPs that cover the common RAGE gene variation were genotyped in 1291 individuals from two Dutch population-based cohort studies, aged 64.5 ± 8.6 years, with normal glucose metabolism (44%), impaired glucose metabolism (23%) or type 2 diabetes mellitus (33%). We used multiple regression analyses to compare prevalent cardiovascular disease and markers of atherosclerosis, blood pressure and arterial stiffness across genotypes, and examine effect modification by glucose metabolism status. Results: In unstratified analyses, no consistent associations between RAGE SNPs and prevalent cardiovascular disease and markers of atherosclerosis were found. However, the AA genotype of SNP rs1800624 (-374T/A) was consistently associated with lower SBP [-5.0 mmHg (95% confidence interval -10.4 to 0.3)] and DBP [-4.2 (-7.2 to -1.3)], pulse pressure [-0.8 (-5.0 to 3.4)] as well as with less arterial stiffness [-0.56 SD (-1.04 to -0.09)] in individuals with normal glucose metabolism, but with higher SBP [6.2 (0.9–11.5)], DBP [2.1 (-0.7 to 5.0)] and pulse pressure [4.1 (-0.2 to 8.4)] in individuals with impaired glucose metabolism or type 2 diabetes mellitus (P for interaction
Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies
Engelen, L. ; Ferreira, I. ; Brouwers, O. ; Henry, R.M.A. ; Dekker, J.M. ; Nijpels, G. ; Heine, R.J. ; Greevenbroek, M.M.J. van; Kallen, C.J.H. van der; Blaak, E.E. ; Feskens, E.J.M. ; Cate, H. ten; Stehouwer, C.D.A. ; Schalkwijk, C.G. - \ 2009
Journal of Hypertension 27 (2009)7. - ISSN 0263-6352 - p. 1399 - 1403.
diabetic complications - methylglyoxal - glycation - biochemistry - hypertension - increases - cells
Objectives Methylglyoxal is a major precursor in the formation of advanced glycation endproducts (AGEs), which are known to contribute to vascular complications such as hypertension and arterial stiffness. Methylglyoxal can be detoxified by glyoxalase 1 (GLO1). Because genetic variation in the GLO1 gene may alter the expression and/or the activity of GLO1, we investigated whether single nucleotide polymorphisms ( SNPs) in the GLO1 gene are associated with vascular complications. Methods The study entailed cross-sectional data analyses of the Cohort study of Diabetes and Atherosclerosis Maastricht (CoDAM) study and the Hoorn study, comprising a total of 1289 participants, aged 64.5 +/- 8.58 years, of whom 43.5% had normal glucose metabolism, 23.2% had impaired glucose metabolism and 33.3% had type 2 diabetes mellitus. Nine tag SNPs that cover the common GLO1 gene variation were genotyped. Levels of blood pressure and markers of atherosclerosis, arterial stiffness, renal function and AGEs were compared across genotypes. Results All genotyped SNPs were in Hardy-Weinberg equilibrium. Prevalence of hypertension and markers of atherosclerosis, arterial stiffness, renal function and AGEs did not differ across genotypes of the nine SNPs. In additive models, SNP18 (rs2736654) was associated with pulse pressure [-1.20 mmHg (95% confidence interval: -2.26;-0.14)] and SNP40 (rs10484854) was associated with systolic blood pressure [-1.77 mmHg (-3.40;-0.14)]. Conclusion Polymorphisms in the GLO1 gene are not associated with the prevalence of hypertension, markers of atherosclerosis, renal function and AGEs and are weakly associated with pulse pressure and systolic blood pressure ( possibly due to chance) in two Dutch cohorts of patients with normal glucose metabolism, impaired glucose metabolism and type 2 diabetes mellitus
Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels
Gaens, K.H. ; Ferreira, I. ; Kallen, C.J. ; Greevenbroek, M.M. ; Blaak, E.E. ; Feskens, E.J.M. ; Dekker, J.M. ; Nijpels, G. ; Heine, R.J. ; Hart, L.M. t; Groot, P.G. ; Stehouwer, C.D. ; Schalkwijk, C.G. - \ 2009
Journal of Clinical Endocrinology and Metabolism 94 (2009)12. - ISSN 0021-972X - p. 5174 - 5180.
coronary-artery-disease - low-grade inflammation - soluble form - gly82ser polymorphism - diabetic-retinopathy - cardiovascular-disease - splice variants - serum-levels - endproducts - codam
Objective: The receptor for advanced glycation end products (RAGE)-ligand interaction has been linked to vascular complications. The family of soluble forms of RAGE (sRAGE) consists of splice variants and proteolytically cleaved and shed forms of RAGE. sRAGE may be a reflection of cell-bound RAGE. Because genetic variation in the RAGE gene may be associated with individual differences in sRAGE concentration and outcome, we investigated whether RAGE single-nucleotide polymorphisms (SNPs) were associated with circulating levels of sRAGE. Methods: Nine SNPs, covering the common RAGE gene variation, were genotyped in a Dutch cohort of subjects with normal glucose metabolism (n = 301), impaired glucose metabolism (n = 127), and type 2 diabetes mellitus (n = 146). We used linear regression analyses adjusted for age, sex, and glucose metabolism status to compare sRAGE levels across genotypes. Results: SNP rs2060700 (Gly82Ser) showed an association with sRAGE levels. Specifically, after adjustments for age, sex, and glucose metabolism, subjects with CT genotype had –527 pg/ml (95% confidence interval –724 to –330, P <0.001) lower sRAGE levels compared with the CC genotype (age, sex, and glucose metabolism adjusted mean ± SE values of 836 ± 99 and 1369 ± 26 pg/ml, respectively, P <0.001). These results were confirmed in a subsample of a second cohort study of subjects with CT (n = 37) and CC genotype (n = 37). Immunoblotting using antibodies against amino acids 39-55 and 100-116 of RAGE also showed a similar decrease of sRAGE levels in the CT genotypes. No other SNPs showed an association with sRAGE levels. In addition, no associations between SNPs and the advanced glycation end products N-(carboxymethyl)lysine and N-(carboxyethyl)lysine were found. Conclusion: The CC genotype of SNP rs2070600 (Gly82Ser) was strongly associated with higher sRAGE levels in a Dutch population. The mechanism by which Gly82Ser polymorphism alters the sRAGE levels remains to be elucidated.
Finse vragenlijst redelijk goede voorspeller van het optreden van diabetes in Nederland = Finnish questionnaire reasonably good predictor of the incidence of diabetes in The Netherlands
Alssema, M. ; Feskens, E.J.M. ; Bakker, S.J. ; Gansevoort, R.T. ; Boer, J.M. ; Heine, R.J. ; Nijpels, G. ; Stehouwer, C.D. ; Kraan, M. ; Dekker, J.M. - \ 2008
Nederlands Tijdschrift voor Geneeskunde 152 (2008)44. - ISSN 0028-2162 - p. 2418 - 2424.
OBJECTIVE: To establish whether the Finnish diabetes risk score for predicting the incidence of diabetes (FINDRISK) is also valid in the Netherlands, and to choose cut-off points suitable for the Dutch situation. DESIGN:. Descriptive. METHOD: The FINDRISK was validated in 3 Dutch cohort studies by means of repeated glucose measurements: the Hoorn study (n=5434), the PREVEND study (n=2713) and part of the Maastricht cohort from the MORGEN study (n=863). The predictive value was evaluated using receiver operating characteristic (ROC) analyses. The risk categories were defined on the basis of sensitivity, specificity and positive predictive value. RESULTS: The predictive value of the FINDRISK was best in the PREVEND cohort (area under the ROC curve 0.77) and was lower for the Hoorn study and the Maastricht cohort (area under the ROC-curve 0.71 for both). The scores were divided into three risk categories: low risk (score lower than 7), slightly increased risk (score 7-9) and increased risk (score so or higher). The percentage of persons with incident diabetes within about 5 years was <6 in the low risk category, 6-14 in the category with slightly increased risk and 12-26 in the category with increased risk. 16-28% of the Dutch population studied had a score of 10 or higher. CONCLUSION: The FINDRISK is a reasonably good predictor for incident diabetes in the Netherlands.
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