Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Chickens selected for different natural antibody levels differ in mortality to intratracheal aerial pathogenic Escherichia coli (APEC) infection
Berghof, T.V.L. ; Matthijs, M.G.R. ; Arts, J.A.J. ; Bovenhuis, H. ; Dwars, R.M. ; Koning, D.B. de; Poel, J.J. van der; Parmentier, H.K. - \ 2017
Metabolite profiles in blood and milk for cows with different dry period lengths in early lactation
Xu, Wei ; Knegsel, A.T.M. van; Koning, D.B. de; Hoeij, R.J. van; Kemp, B. ; Vervoort, J.J.M. - \ 2016
In: 16th International Conference on Production Diseases in Farm Animals. - Wageningen : Wageningen Academic - ISBN 9789086862856 - p. 120 - 120.
Metabolite profiles in blood and milk for cows with different dry period lengths in early lactation
Xu, Wei ; Knegsel, A.T.M. van; Koning, D.B. de; Hoeij, R.J. van; Kemp, B. ; Vervoort, J.J.M. - \ 2016
Chickens selected for different natural antibody levels differ in mortality to intratracheal aerial pathogenic Escherichia coli (APEC) infection
Berghof, T.V.L. ; Matthijs, M.G.R. ; Arts, J.A.J. ; Bovenhuis, H. ; Dwars, R.M. ; Koning, D.B. de; Poel, J.J. van der; Parmentier, H.K. - \ 2016
Relationship between ovulation rate in sows and litter characterisics at birth
Lima Alvares da Silva, Carolina ; Koning, D.B. de; Laurenssen, B.F.A. ; Mulder, H.A. ; Knol, E.F. ; Kemp, B. ; Soede, N.M. - \ 2016
Cow characteristics and their association with udder health after different dry period lengths
Hoeij, R.J. van; Lam, T.J.G.M. ; Koning, D.B. de; Steeneveld, W. ; Kemp, B. ; Knegsel, A.T.M. van - \ 2016
Journal of Dairy Science 99 (2016)10. - ISSN 0022-0302 - p. 8330 - 8340.
Clinical mastitis - Continuous milking - Decision making - Somatic cell count

Shortening or omitting the dry period (DP) in dairy cows is of interest because of potential beneficial effects on energy balance and metabolic health. Reported effects of a short or omitted dry period on udder health are ambiguous. This study aimed to evaluate the effect of no DP (0 d), a short DP (30 d), or a conventional DP (60 d) on the occurrence of intramammary infections (IMI) during the precalving period and on somatic cell counts (SCC), elevations of SCC (SCC ≥ 200,000 cells/mL), and clinical mastitis in the subsequent lactation. The study also aimed to analyze which prepartum cow characteristics are associated with udder health after different DP lengths. Holstein-Friesian dairy cows (n = 167) were randomly assigned to a DP length (0, 30, or 60 d). Cows with a 0-d DP had a greater occurrence of chronic IMI and a lower occurrence of cured IMI during the precalving period than cows with a 30-d or 60-d DP. Postpartum average SCC for lactation was greater in cows with a 0-d DP than in cows with a 30-d or 60-d DP. The number of cows with at least 1 elevation of SCC, the number of elevations of SCC per affected cow, the number of cows treated for clinical mastitis, and the number of cases of mastitis per affected cow did not differ among DP lengths. Cow characteristics related to postpartum average SCC for lactation were DP length, parity, and the following interactions: DP length with prepartum elevation of SCC, DP length with fat- and protein-corrected milk (FPCM) reduction between 150 and 67 d prepartum, DP length with parity and with average SCC for lactation, and last FPCM before the conventional drying-off day with average SCC for lactation. Cows with prepartum parity 1 had a lower occurrence of at least 1 elevation of SCC in subsequent lactation compared with cows with parity >2. Last SCC before the conventional drying-off day was positively associated with occurrence of clinical mastitis in the subsequent lactation. In this study, DP length was not a risk factor for either elevation of SCC or occurrence of clinical mastitis in the subsequent lactation. The identified cow characteristics could be used in a decision support model to optimize DP length for individual cows.

Effects of a high carbohydrate diet and arginine supplementation during the rearing period of gilts on osteochondrosis prevalence at slaughter
Koning, D.B. de; Laurenssen, B.F.A. ; Koopmanschap, R.E. ; Grevenhof, E.M. van; Weeren, P.R. van; Hazeleger, W. ; Kemp, B. - \ 2016
Livestock Science 188 (2016). - ISSN 1871-1413 - p. 91 - 102.
Arginine - Carbohydrate - Fat diet - Gilts - Osteochondrosis

Osteochondrosis (OC) is a consequence of necrotic growth cartilage formation early in life and suggested to be associated with lameness and premature culling of sows. Higher insulin, glucose, and insulin-like growth factor-1 (IGF-1) are associated with increased OC in horses and are affected by carbohydrates. If dietary composition can affect OC through metabolic parameters in sows, it could be a tool in practice to reduce OC prevalence. This study examined if OC prevalence in rearing gilts can be influenced by dietary carbohydrates and/or arginine by affecting IGF-1, insulin, glucose, and nitric oxide (NO) levels. Gilts (n=212; Dutch Large White x Dutch Landrace) were acquired after weaning (4 weeks of age). At 6 weeks of age, gilts were subjected to a 2×2 factorial treatment design of dietary carbohydrate and arginine level scale fed at pen level. Carbohydrate level consisted of 12.5% cornstarch and 12.5% dextrose added to a basal diet (C+) versus an isocaloric diet in which cornstarch and dextrose were replaced with 8.9% soya bean oil (C-). Arginine supplementation consisted of 0.8% arginine supplemented to a basal diet (A+) versus 1.64% alanine as the isonitrogenous control (A-). At 24 weeks of age, blood samples of in total 34 gilts around feeding were taken and assessed for insulin, glucose, IGF-1, and NO levels. After slaughter at 25 weeks of age, OC was scored on the elbow, knee, and hock joints. Gilts in the C- treatment had higher glucose and insulin levels 90 min after feeding onwards and higher IGF-1 levels than gilts in the C+ treatment (P

The influence of dietary restriction and floor type before and after 10 weeks of age on osteochondrosis in growing gilts
Koning, D.B. de; Grevenhof, E.M. van; Laurenssen, B.F.A. ; Hazeleger, W. ; Kemp, B. - \ 2015
In: Proceedings of the WIAS Science Day 2015 - Facing the Future. - WIAS - p. 28 - 28.
Linking early life conditions to osteochondrosis prevalence in gilts
Koning, D.B. de - \ 2015
Wageningen University. Promotor(en): Bas Kemp, co-promotor(en): Ilse van Grevenhof; Wouter Hazeleger. - Wageningen : Wageningen University - ISBN 9789462575042 - 234
gelten - osteochondritis - varkensvoeding - vloertypen - bouw (dier) - voortbeweging - antilichamen - koolhydraatrijk voedsel - arginine - voedersupplementen - diergezondheid - gilts - pig feeding - floor type - conformation - locomotion - antibodies - carbohydrate-rich foods - feed supplements - animal health

Osteochondrosis (OC) involves the development of necrotic growth cartilage near the surface of a joint and is suggested to be associated with lameness in sows. Development of OC in pigs occurs at young age in a relatively short time frame of several weeks around 10 weeks of age. Due to this time dependency, one may wonder whether there are time dependent effects of factors or conditions associated with OC. The aim of this thesis was to assess whether OC prevalence is associated with conditions encountered in early life such as dietary restriction, floor type, conformation and locomotive characteristics (CLC), natural (auto-) antibodies (N[A]Ab), and carbohydrate levels. Indications for time dependent effects were found for dietary restriction on OC prevalence. This indicated that gilts receiving restricted feeding from 4 to 10 weeks of age and switched to ad libitum feeding until 26 weeks of age had a significantly higher prevalence of OC when compared to gilts receiving restricted feeding after 10 weeks of age. Time dependent effects of floor type were not clearly present, but gilts housed on a deep litter type system using wood shavings after weaning had a higher prevalence of severe OC when compared to gilts kept on a concrete partially slatted floor. Feed with a lower carbohydrate level increased OC prevalence compared to feed with a higher carbohydrate level. We hypothesized that the effects of dietary restriction, floor type, and dietary carbohydrate levels were mediated through loading of the joints either by, respectively, a short rapid increase in weight gain, higher incidence of play behaviors, or by an overall increased body weight. Although OC has been suggested to be associated with various CLC such as lameness, a consistent association of CLC at young age with OC at slaughter could not be found. This is likely due to CLC and OC both varying over time, making associations between the 2 entities complicated. There were indications that a component of the immune system is associated with OC as N(A)Ab against several antigens were found after weaning in association with OC. However, as with the CLC, associations with OC were not consistent over time, making it difficult to discern the exact associations between N(A)Ab and OC. To conclude, several early life conditions were found to affect or be associated with OC prevalence in gilts. This indicates that if one wants to reduce OC prevalence, one needs to start early after weaning. However, the exact implications of OC on CLC such as lameness and, therefore, welfare remain uncertain and require further studies into the long term welfare effects of OC.

Association of natural (auto-) antibodies in young gilts with osteochondrosis at slaughter
Koning, D.B. de; Damen, E.P.C.W. ; Nieuwland, M.G.B. ; Grevenhof, E.M. van; Hazeleger, W. ; Kemp, B. ; Parmentier, H.K. - \ 2015
Livestock Science 176 (2015). - ISSN 1871-1413 - p. 152 - 160.
serum-free culture - growth cartilage - epiphyseal growth - immune-responses - growing gilts - dairy-cows - chondrocytes - pigs - proteoglycans - lesions
Osteochondrosis (OC) develops at a young age and has been associated with lameness and reduced longevity of sows. Early detection of OC is therefore beneficial for selection against OC. Possibly, immunological components within the blood may serve as an indicator for OC development and could therefore be used as a biomarker. Levels of naturally occurring (auto-) antibodies (N[A]Ab) have been associated with homeostatic imbalance and various forms of inflammation, and may have an association with OC. The aim of this study was to investigate possible associations between the presence and levels of N(A)Ab of the IgM and IgG isotypes at an early age with OC in growing gilts at slaughter (24 weeks of age). Plasma samples were obtained from 212 Topigs 20 (Dutch Large White x Dutch Landrace) gilts at 6, 10, and 24 weeks of age and analyzed for N(A)Ab titers against 11 (auto-) antigens using ELISA. After slaughter, the elbow, hock, and knee joints were macroscopically examined for OC status. Due to low prevalence of OC in the elbow joint (5.4%), the elbow joint was not taken into account in analyses. Significant (P=0.05) associations with OC in both the hock joint and at the animal level (all joints combined) were found for IgM titers against chondroitin sulfate A at 6 weeks of age (OR 1.4 and 1.5), actin at 6 weeks of age (OR 1.4 and 1.3), thyroglobulin at 24 weeks of age (OR 1.5 and 1.3), and IgG titers against insulin at 6 weeks of age (OR 1.7 and 1.4). Additionally, significant (P=0.05) associations with OC were found at the knee joint for IgM titers against albumin at 6 weeks of age (OR 2.3), at the hock joint for IgM titers against keyhole limpet hemocyanin at 6 weeks of age (OR 1.4), and at the animal level for IgM titers against actin at 24 weeks of age (OR 1.3). This study indicated for the first time associations between the presence and levels of N(A)Ab at a young age and OC at 24 weeks of age in breeding gilts.
Associations of conformation and locomotive characteristics in growing gilts with osteochondrosis at slaughter
Koning, D.B. de; Grevenhof, E.M. van; Laurenssen, B.F.A. ; Hazeleger, W. ; Kemp, B. - \ 2015
Journal of Animal Science 93 (2015)1. - ISSN 0021-8812 - p. 93 - 106.
linear type traits - leg weakness - exterior traits - genetic correlations - epiphyseal growth - pigs - cartilage - sows - lesions - pathogenesis
Osteochondrosis (OC) and abnormalities in conformation and locomotive characteristics (CLC) have been associated with premature culling in sows. Several CLC have been suggested to be associated with OC and might help as an in vivo indicator for and increased risk of having OC. The aim of this study was to investigate associations of OC with CLC assessed at several ages in growing gilts from 2 separate experiments over the effects of dietary restriction (Exp. 1) and floor type (Exp. 2) on OC prevalence. In Exp. 1, gilts (n = 211) were subjectively assessed for CLC at, on average, 4, 9, 11, 16, and 24 wk of age. In Exp. 2, gilts (n = 212) were subjectively assessed for CLC at, on average, 4, 9, 11, 16, and 22 wk of age. Assessment was done on 10 conformation and 2 locomotive characteristics using a 9-point grading scale by 2 observers. At, on average, 27 wk of age in Exp. 1 and 24 wk of age in Exp. 2, gilts were slaughtered and the knee, elbow, and hock joints were macroscopically assessed for OC. The CLC most frequently associated with OC were O shape or X shape of the hind legs, straight or bowed hind legs, and straight or sickled hock. X-shaped hind legs were associated with OC at slaughter in the knee joint at 4, 9, and 24 wk of age and at the animal level (all joints taken together) at 4, 9, and 16 wk of age. Straight or bowed hind legs were associated with OC at slaughter in the knee joint at 4 and 11 wk of age; in the hock joint at 11 wk of age; and at the animal level at 4, 9, 11, and 22 wk of age. Straight or sickled hock was associated with OC at slaughter in the knee joint at 4 wk of age, in the hock joint at 9 and 22 wk of age, and at the animal level at 9 and 22 wk of age. Results show that several CLC assessed at several ages were associated with OC, but consistent associations of a type of CLC in every assessment could not be found. The associations of CLC with OC are, therefore, difficult to be used as an in vivo indicator of increased risk for OC.
The influence of flooring type before and after 10 weeks of age on osteochondrosis in gilts
Koning, D.B. de; Grevenhof, E.M. van; Laurenssen, B.F.A. ; Weeren, P.R. van; Hazeleger, W. ; Kemp, B. - \ 2014
In: Book of Abstracts of the 65th Annual Meeting of the European Federation of Animal Science (EAAP). - Wageningen, The Netherlands : Wageningen Academic Publishers - ISBN 9789086862481 - p. 381 - 381.
The influence of flooring type before and after 10 weeks of age on osteochondrosis in gilts
Koning, Danny de - \ 2014
The influence of floor type before and after 10 weeks of age on osteochondrosis in growing gilts
Koning, D.B. de; Grevenhof, E.M. van; Laurenssen, B.F.A. ; Weeren, P.R. van; Hazeleger, W. ; Kemp, B. - \ 2014
Journal of Animal Science 92 (2014)8. - ISSN 0021-8812 - p. 3338 - 3347.
different coping characteristics - leg weakness - finishing pigs - growth-rate - genetic-parameters - epiphyseal growth - production traits - stocking density - claw disorders - behavior
Osteochondrosis (OC) is a degenerative joint condition developing in a short time frame in young growing gilts that may cause lameness at an older age, affecting welfare and leading to premature culling of breeding sows. Causes of OC are multifactorial including both genetic and environmental factors. Floor type has been suggested to affect OC prevalence and effects might be age dependent during the rearing period. The aim of this study was to investigate possible age-dependent effects of floor type, conventional concrete partially slatted versus wood shavings as deep bedding, on OC prevalence in gilts (Dutch Large White × Dutch Landrace) at slaughter (24 wk of age; 106.5 [14.7 SD] kg of BW). At weaning (4 wk of age; 6.9 [1.3 SD] kg of BW), 212 gilts were subjected to 1 of 4 flooring regimens. Gilts were either subjected to a conventional floor from weaning until slaughter (CC), wood shavings as bedding from weaning until slaughter (WW), a conventional floor from weaning until 10 wk of age after which gilts were switched to wood shavings as bedding (CW), or wood shavings as bedding from weaning until 10 wk of age after which gilts were switched to a conventional floor (WC). After slaughter the elbow, hock, and knee joints were macroscopically examined for OC and scored on a 5 point scale where 0 indicates no OC and 4 indicates the severest form of OC. There was no significant difference (P > 0.4) between treatments on the overall OC prevalence for any joint assessed or at the animal level (all joints combined). At the animal level, however, gilts had greater odds to have OC scores 3 and 4 in the CW treatment (odds ratios [OR] = 2.3; P = 0.05), WC treatment (OR = 2.6; P = 0.02), and WW treatment (OR = 3.7; P <0.001) compared with gilts in the CC treatment. The results indicate that there are no age-dependent effects of floor types on overall OC prevalence. However, wood shavings as bedding seems to increase the odds for severe OC and might affect animal welfare in the long term.
The influence of flooring type before and after 10 weeks of age on osteochondrosis in gilts
Koning, D.B. de - \ 2014
Overbelast groeikraakbeen kan hele varkensleven een handicap blijven; Schokbreker sparen
Lamers, J. ; Grevenhof, E.M. van; Koning, D.B. de - \ 2014
Varkens 2014 (2014)maart. - ISSN 0166-5952 - p. 22 - 23.
Klauwproblemen zijn niet de enige oorzaak van kreupele zeugen. Slecht kraakbeen in de gewrichten kan ook de oorzaak zijn. Dat ontstaat al rond een leeftijd van 10 weken. Huisvesting en voeding kunnen dit proces beïnvloeden.
The influence of feeding levels before and after 10 weeks of age on osteochondrosis in growing gilts
Koning, D.B. de; Grevenhof, E.M. van; Laurenssen, B.F.A. ; Weeren, P.R. van; Hazeleger, W. ; Kemp, B. - \ 2013
In: Book of Abstracts of the 64th Annual Meeting of the European Federation of Animal Science, 26-30 August 2013, Nantes, France. - Wageningen : Wageningen Academic Publishers - ISBN 9789086862283 - p. 448 - 448.
The influence of feeding levels before and after 10 weeks of age on osteochondrosis in growing gilts
Koning, D.B. de; Grevenhof, E.M. van; Laurenssen, B.F.A. ; Weeren, P.R. van; Hazeleger, W. ; Kemp, B. - \ 2013
The influence of dietary restriction before and after 10 weeks of age on osteochondrosis in growing gilts
Koning, D.B. de; Grevenhof, E.M. van; Laurenssen, B.F.A. ; Weeren, P.R. van; Hazeleger, W. ; Kemp, B. - \ 2013
Journal of Animal Science 91 (2013)11. - ISSN 0021-8812 - p. 5167 - 5176.
leg weakness - growth-rate - articular chondrocytes - genetic-parameters - epiphyseal growth - production traits - pigs - cartilage - lesions - pathogenesis
Osteochondrosis (OC) is one of the main causes of leg weakness causing premature culling in breeding sows and develops in a short time frame in young growing gilts. Dietary restriction may have different effects on OC prevalence depending on the age of the gilts. The aim of this study is to investigate age dependent effects of dietary restriction, ad libitum versus restricted (80% of ad libitum), on the occurrence of OC in gilts at slaughter (26 wk of age). At weaning (4 wk of age), 211 gilts were subjected to one of 4 treatments of feeding regime. Gilts were administered either ad libitum feeding from weaning until slaughter (AA); restricted feeding from weaning until slaughter (RR); ad libitum feeding from weaning until 10 wk of age, after which gilts were switched to restricted feeding (AR); or restricted feeding from weaning until 10 wk of age, after which gilts were switched to ad libitum feeding (RA). At slaughter, the elbow, hock, and knee joints were harvested. Joints were scored macroscopically for articular surface deformations indicative of OC. Gilts in the RA treatment had significantly higher odds to be affected with OC than gilts in the RR and AR treatments in the hock joint (OR = 3.3, P = 0.04 and OR = 8.5, P = 0.002, respectively), and at animal level (OR = 2.5, P = 0.001 and OR = 1.9, P = 0.01, respectively). Gilts in the AA treatment had higher odds to be affected with OC than gilts in the AR treatment in the hock joint (OR = 5.3, P = 0.01). The results indicate a possible pathway to reduce the prevalence of OC in breeding gilts which will have to last several parities. Switching from restricted feeding to ad libitum feeding after 10 wk of age increases OC prevalence as opposed to restricted feeding after 10 wk of age.
The influence of feeding levels and their age dependent effects on osteochondrosis (OC) in gilts
Koning, D.B. de; Grevenhof, E.M. van; Laurenssen, B.F.A. ; Weeren, P.R. van; Hazeleger, W. ; Kemp, B. - \ 2013
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