Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Levels and trends in cardiovascular risk factors and drug treatment in 4837 eldery Dutch myocardial infarction patients between 2002 and 2006
Soedamah-Muthu, S.S. ; Geleijnse, J.M. ; Giltay, E.J. ; Goede, J. de; Oude Griep, L.M. ; Waterham, E. ; Teitsma-Jansen, A.M. ; Mulder, B.J.M. ; Boer, M.J. de; Deckers, J.W. ; Zock, P.L. ; Kromhout, D. - \ 2012
Netherlands Heart Journal 20 (2012)3. - ISSN 1568-5888 - p. 102 - 109.
coronary-heart-disease - life-style - prevention - mortality - guidelines - trial
Background It is important to gain insight into opportunities for secondary prevention of cardiovascular disease. Our aim was to investigate levels and trends in cardiovascular risk factors and drug treatment in Dutch post-myocardial infarction (MI) patients between 2002 and 2006 and to make comparisons with the EUROASPIRE surveys (1999–2007). Methods We analysed data from 4837 post-MI patients (aged 69 years, 78% men) from 32 Dutch hospitals, using baseline cross-sectional data from the Alpha Omega Trial. Results Between 2002 and 2006, significant declines were found in the prevalence of smoking (23% to 16%, p¿
N-3 fatty acids, ventricular arrhythmia-related events, and fatal myocardial infarction in postmyocardial infarction patients with diabetes
Kromhout, D. ; Geleijnse, J.M. ; Goede, J. de; Oude Griep, L.M. ; Mulder, B.J.M. ; Boer, M.J. de; Deckers, J.W. ; Boersma, E. ; Zock, P.L. ; Giltay, E.J. - \ 2011
Diabetes Care 34 (2011)12. - ISSN 0149-5992 - p. 2515 - 2520.
coronary-heart-disease - base-line characteristics - placebo-controlled trial - cardiovascular-disease - dietary-supplements - sudden-death - fish intake - risk - omega-3-fatty-acids - mortality
OBJECTIVE We carried out a secondary analysis in high-risk patients with a previous myocardial infarction (MI) and diabetes in the Alpha Omega Trial. We tested the hypothesis that in these patients an increased intake of the n-3 fatty acids eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and a-linolenic acid (ALA) will reduce the incidence of ventricular arrhythmias and fatal MI. RESEARCH DESIGN AND METHODS A subgroup of 1,014 post-MI patients with diabetes aged 60–80 years was randomly allocated to receive one of four trial margarines, three with an additional amount of n-3 fatty acids and one placebo for 40 months. The end points were ventricular arrhythmia–related events and fatal MI. The data were analyzed according to the intention-to-treat principle, using multivariable Cox proportional hazards models. RESULTS The patients consumed on average 18.6 g of margarine per day, which resulted in an additional intake of 223 mg EPA plus 149 mg DHA and/or 1.9 g ALA in the active treatment groups. During follow-up, 29 patients developed a ventricular arrhythmia–related events and 27 had a fatal MI. Compared with placebo patients, the EPA-DHA plus ALA group experienced less ventricular arrhythmia–related events (hazard ratio 0.16; 95% CI 0.04–0.69). These n-3 fatty acids also reduced the combined end-point ventricular arrhythmia–related events and fatal MI (0.28; 0.11–0.71). CONCLUSIONS Our results suggest that low-dose supplementation of n-3 fatty acids exerts a protective effect against ventricular arrhythmia–related events in post-MI patients with diabetes
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