Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

  • help
  • print

    Print search results

  • export

    Export search results

  • alert
    We will mail you new results for this query: metisnummer==1173562
Check title to add to marked list
Campylobacter jejuni capsular genotypes are related to Guillain-Barré syndrome
Heikema, A.P. ; Islam, Z. ; Horst-Kreft, D. ; Huizinga, R. ; Jacobs, B.C. ; Wagenaar, J.A. ; Poly, F. ; Guerry, P. ; Belkum, A. van; Parker, C.T. ; Endtz, H.P. - \ 2015
Clinical Microbiology and Infection 21 (2015)9. - ISSN 1198-743X - p. 852.e1 - 852.e9.
Campylobacter jejuni - Capsular genotype - Guillain-Barré syndrome - Lipo-oligosaccharide - Multilocus sequence typing

In about one in a thousand cases, a Campylobacter jejuni infection results in the severe polyneuropathy Guillain-Barré syndrome (GBS). It is established that sialylated lipo-oligosaccharides (LOS) of C.jejuni are a crucial virulence factor in GBS development. Frequent detection of C.jejuni with sialylated LOS in stools derived from patients with uncomplicated enteritis implies that additional bacterial factors should be involved. To assess whether the polysaccharide capsule is a marker for GBS, the capsular genotypes of two geographically distinct GBS-associated C.jejuni strain collections and an uncomplicated enteritis control collection were determined. Capsular genotyping of C.jejuni strains from the Netherlands revealed that three capsular genotypes, HS1/44c, HS2 and HS4c, were dominant in GBS-associated strains and capsular types HS1/44c and HS4c were significantly associated with GBS (p 0.05 and p 0.01, respectively) when compared with uncomplicated enteritis. In a GBS-associated strain collection from Bangladesh, capsular types HS23/36c, HS19 and HS41 were most prevalent and the capsular types HS19 and HS41 were associated with GBS (p 0.008 and p 0.02, respectively). Next, specific combinations of the LOS class and capsular genotypes were identified that were related to the occurrence of GBS. Multilocus sequence typing revealed restricted genetic diversity for strain populations with the capsular types HS2, HS19 and HS41. We conclude that capsular types HS1/44c, HS2, HS4c, HS19, HS23/36c and HS41 are markers for GBS. Besides a crucial role for sialylated LOS of C.jejuni in GBS pathogenesis, the identified capsules may contribute to GBS susceptibility.

Check title to add to marked list

Show 20 50 100 records per page

Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.