Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Molecular assessment of muscle health and function : The effect of age, nutrition and physical activity on the human muscle transcriptome and metabolom
Hangelbroek, Roland W.J. - \ 2017
University. Promotor(en): Sander Kersten; Lisette de Groot, co-promotor(en): Mark Boekschoten. - Wageningen : Wageningen University - ISBN 9789463437103 - 205
muscles - age - nutrition - physical activity - transcriptomes - metabolomes - elderly - creatine - phosphocreatine - vitamin d - atrophy - spieren - leeftijd - voeding - lichamelijke activiteit - transcriptomen - metabolomen - ouderen - fosfocreatine - vitamine d - atrofie

Prolonged lifespan and decreased fertility will lead to an increased proportion of older adults in the world population (population aging). An important strategy to deal with population aging has been to promote healthy aging; not only to prevent mounting health care costs, but also to maintain independence and quality of life of older populations for as long as possible. Close to the opposite of the healthy aging is frailty. A major component of (physical) frailty is sarcopenia: age-related loss of muscle mass. Decreased muscle size and strength has been associated with a wide variety of negative health outcomes, including increased risk of hospitalization, physical disability and even death. Therefore, maintaining muscle size and strength is very important for healthy aging. Nutrition and physical activity are possible strategies to maintain or even improve muscle function with age.

The effect of nutrition, age, frailty and physical activity on the function of skeletal muscle is complex. A better understanding of the molecular mechanisms involved can provide new insights in potential strategies to maintain muscle function over the life course. This thesis aims to investigate these mechanisms and processes that underlie the effects of age, frailty and physical activity by leveraging the sensitivity and comprehensiveness of transcriptomics and metabolomics.

Chapter 2 and 3 describe the effects of age, frailty and resistance-type exercise training on the skeletal muscle transcriptome and metabolome. Both the transcriptome and metabolome show significant differences between frail and healthy older adults. These differences are similar to the differneces between healthy young men and healthy older adults, suggesting that frailty presents itself as a more pronounced form of aging, somewhat independent of chronological age. These age and frailty related differences in the transcriptome are partially reversed by resistance-type exercise training, in accordance with the observed improvement in muscle strength. Regression analysis revealed that the protocadherin gamma gene cluster may be important to skeletal muscle function. Protocadherin gamma is involved in axon guidance and may be upregulated due to the denervation-reinnervation cycles observed in skeletal muscle of older individuals. The metabolome suggested that resistance-type exercise training led to a decrease in branched-chain amino acid oxidation, as shown by a decrease in amino acid derived carnitines. Lastly, the blood metabolome showed little agreement with the metabolome in skeletal muscle, indicating that blood is a poor read-out of muscle metabolism.

We assessed the effect of knee immobilization with creatine supplementation or placebo on the skeletal muscle transcriptome and metabolome in chapter 4. Knee immobilization caused muscle mass loss and strength loss in all participants, with no differences between creatine and placebo groups. Knee immobilization appeared to induce the HDAC4-myogenin axis, which is primarily associated with denervation and motor neuron diseases. The metabolome showed changes consistent with the decreased expression of energy metabolism genes. While acyl-carnitine levels tended to decrease with knee immobilization, one branched-chain amino acid-derived acyl carnitine was increased after knee immobilization, suggesting increased amino acid oxidation.

Vitamin D deficiency is common among older adults and has been linked to muscle weakness. Vitamin D supplementation has been proposed as a strategy to improve muscle function among older populations. In chapter 5, supplementation with vitamin D (calcifediol, 25(OH)D) is investigated as nutritional strategy to improve muscle function among frail older adults. However, we observed no effect of vitamin D on the muscle transcriptome. These findings indicate the effects of vitamin D supplementation on skeletal muscle may be either absent, weak, or limited to a small subset of muscle cells.

Transcriptomic changes due to different forms of muscle disuse are compared in chapter 6 (primarily knee immobilization and bed rest). The goal was to determine the similarities and differences among various causes of muscle atrophy in humans (primarily muscle disuse). Both knee immobilization and bed rest led to significant changes in the muscle transcriptome. However, the overlap in significantly changed genes was relatively small. Knee immobilization was characterized by ubiquitin-mediated proteolysis and induction of the HDAC4/Myogenin axis, whereas bed rest revealed increased expression of genes of the immune system and increased expression of lysosomal genes. Knee immobilization showed the highest similarity with age and frailty-related transcriptomic changes. This finding suggests that knee immobilization may be the most suitable form of disuse atrophy to assess the effectiveness of strategies to prevent age-related muscle loss in humans.

The transcriptome and metabolome are incredibly useful tools in describing the wide array of biological systems within skeletal muscle. These systems can be modulated using physical activity (or lack thereof) as well as nutrition. This thesis describes some of these processes and highlights several unexplored genes and metabolites that may be important for maintaining or even optimizing muscle function. In the future, it may be possible to optimize both exercise and nutrition for each individual using these techniques; or even better, cheaper and less invasive alternatives.

FEM growth and yield data monocultures - Common beech, revised version
Goudzwaard, L. ; Jansen, J. ; Oosterbaan, A. ; Oldenburger, J.F. ; Lu, H. ; Mohren, G.M.J. - \ 2017
Growth and yield, even-aged monoculture forest - understorey - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Common beech - Fagus sylvatica
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantations of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monoculures - Scots pine (revised edition)
Lu, Huicui ; Jansen, J.J. ; Oosterbaan, A. ; Goudzwaard, L. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2017
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - monitoring - Scots pine - Pinus sylvestris
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data Monocultures - Poplar (revised version)
Mohren, G.M.J. ; Goudzwaard, L. ; Jansen, J.J. ; Schmidt, P. ; Oosterbaan, A. ; Oldenburger, J. ; Ouden, J. den - \ 2017
Growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - mean height - spacing - without thinning - systematic thinning - monitoring - Poplar - Aspen - Populus species - Populus x canadensis - Populus x interamericana - Populus alba - Populus tremula
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantations of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren. In the FEM growth and yield data collection for even-aged monocultures in general the data of four main studies and if available some additional studies are assembled: 1. Thinning research Wageningen University initiated by Becking1 1947 – 2005. For poplar there are no recordings after 1992. In total 58 monoculture plots were selected with ini-tial number of trees varying from 86 till 2207. Different varieties and a few aspen plots were selected. The treatments consisted of without thinning (28 plots), systematic thin-ning (35 plot) and thinning from below (2 plots). Over more than four decades, this study was supervised by A. van Laar, P.G. de Vries, J.H. Hildebrand, J.J. Jansen and H.H. Bartel-ink; 2. Growth and production study by research institute Dorschkamp/IBN 1923 – 1995. The aim of this research was the construction of yield tables. See Van Soest2 for the experi-mental design. There are 188 poplar plots in this study, but only the plots with 3 or more recordings were selected, in total 77 plots with known age but unknown recording date. But beside this plots there are also 5 aspen plots of which 4 with only 2 recordings with known age and recording date; 3. Spacing trials by research institute IBN 1960 – 1995; 6 plots with known age but un-known recording date; 4. HOSP3 1984 – 2000. A collection of about 3000 permanent sample point from the Dutch National Forest Inventory. In total 42 monocultures with poplar species or varieties were selected; 5. (only for douglas fir); 6. (only for douglas fir); 7. (only for Norway spruce); 8. Nelder Spacing trial by research institute IBN 1976-19954, containing 5 experimental Nelder fields of which 3 with poplar varieties with 6 to 9 series with equal spacing per tree. One series within the Nelder field is seen as a plot, resulting in 21 plots, but hence these plots are not all mutually independent
FEM growth and yield data monocultures - Common Oak (revised version)
Oosterbaan, A. ; Jansen, J.J. ; Goudzwaard, L. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - understory - tree height - tree diameter - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - common oak - Quercus robur
The current database is a part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantations of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data mixed species forest
Bartelink, H.H. ; Jansen, J.J. ; Goudzwaard, L. ; Lu, Huicui ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even aged mixed species forest - tree diameter - tree height - crown class - crown diameter - crown base - coordination stem positions - age - top height - dominant height - dominant diameter - monitoring - ash common beech - common oak - Douglas fir - Japanese larch - Scots pine - silver birch - sycamore - Acer pseudoplatanus - Betula pendula - Fagus sylvatica - Fraxinus excelsior - Larix kaempferi - Quercus robur - Pinus sylvestris - Pseudotsuga mensisii
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species with only a few plots like grand fir, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantations of poplar). The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - White willow
Jansen, J.J. ; Oosterbaan, A. ; Goudzwaard, L. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - monitoring - White willow - Salix alba
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Sycamore
Oldenburger, J.F. ; Jansen, J.J. ; Oosterbaan, A. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Sycamore - Acer pseudoplatanus
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Ash
Goudzwaard, L. ; Jansen, J.J. ; Oosterbaan, A. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Ash - Fraxinus excelsior
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - other species
Goudzwaard, L. ; Jansen, J.J. ; Oosterbaan, A. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Black alder (Alnus glutinosa) - Black locust (Robinia pseudocacia - European hornbeam (Carpinus betulus) - European larch (Larix decidua) - Elm (Ulmus species) - Eastern white pine (Pinus strobus) - Lodgepole pine (Pinus contorta) - Maritime pine ( Pinus maritima) - Port Orford cedar (Chamaecyparis lawsoniana) - Sweet chestnut (Castanea sativa) - Serbian spruce (Picea omorika) - Silver fir (Abies alba) - Western hemlock (Tsuga hetrophylla) - Western red ceder (Thuja plicata) - Wild cherry (Prunus avium)
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Douglas fir
Schoonderwoerd, H. ; Jansen, J.J. ; Mohren, G.M.J. ; Oosterbaan, A. ; Oldenburger, J.F. ; Goudzwaard, L. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Douglas fir - Pseudotsuga menziesii
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oad and several other species with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantations of poplar). The FEM growth and yield data base is currently supervised bu Jan den Ouden and Frits Mohren.
FEM growth and yield data - Common oak
Oosterbaan, A. ; Jansen, J.J. ; Goudzwaard, L. ; Lu, Huicui ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - understory - tree height - tree diameter - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Common oak - Quercus robur
The current database is a part of the FEM growth and yield database, a collecction of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantations of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monoculures - Scots pine
Lu, Huicui ; Jansen, J.J. ; Oosterbaan, A. ; Goudzwaard, L. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - monitoring - Scots pine - Pinus sylvestris
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Common beech
Goudzwaard, L. ; Jansen, J.J. ; Oosterbaan, A. ; Oldenburger, J.F. ; Lu, Huicui ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - understory - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant diameter - monitoring - Common beech - Fagus sylvatica
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Silver birch
Oldenburger, J.F. ; Jansen, J.J. ; Oosterbaan, A. ; Lu, Huicui ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - silver birch - Betula pendula
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is
FEM growth and yield data monocultures - Austrian pine
Oosterbaan, A. ; Jansen, J.J. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Austrian Pine - Pinus nigra subsp. nigra var. nigra
The current database is a part of the FEM growth and yield database, a collecction of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantations of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Corsican pine
Oosterbaan, A. ; Jansen, J.J. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Corsican pine - Pinusnigra subsp. salzmannii var. corsicana
The current database is a part of the FEM growth and yield database, a collecction of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantations of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Red oak
Oosterbaan, A. ; Jansen, J.J. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Red oak - Quercus rubra
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Poplar
Mohren, G.M.J. ; Goudzwaard, L. ; Jansen, J.J. ; Oosterbaan, A. ; Oldenburger, J.F. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - Lorey's mean hight - spacing - without thinning - systematiclly thinning - monitoring - Poplar - Aspen - Populus species - Populus x canadensis - Populus x interamericana - Populus alba - Populus tremula
The current database is part of the FEM growth and yield database, a collection of growth and yield data from even-aged monocultures (douglas fir, common oak, poplar, Japanese Larch, Norway spruce, Scots pine, Corsican pine, Austrian pine, red oak and several other species, with only a few plots, even-aged mixed species forest plots, uneven-aged natural forest, uneven-aged selection forest and roadside plantattions of poplar. The FEM growth and yield data base is currently supervised by Jan den Ouden and Frits Mohren.
FEM growth and yield data monocultures - Grand fir
Jansen, J.J. ; Oosterbaan, A. ; Oldenburger, J.F. ; Mohren, G.M.J. ; Ouden, J. den - \ 2016
growth and yield - even-aged monoculture forest - tree diameter - tree height - crown class - coordinates stem positions - age - top height - dominant height - dominant diameter - monitoring - Grand fir - Abies grandis
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