Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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    We will mail you new results for this query: keywords==antibioticaresistentie
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Antibiotic residues and resistance in the environment
Pikkemaat, M.G. ; Yassin, H. ; Fels-Klerkx, H.J. ; Berendsen, B.J.A. - \ 2016
Wageningen : RIKILT Wageningen UR (RIKILT-report 2016.009) - 31
antibiotic residues - antibiotic resistance - antibiotics - environment - antibioticumresiduen - antibioticaresistentie - antibiotica - milieu
Antibiotic usage has benefited the animal industry and helped providing affordable animal proteins to the growing human population. However, since extensive use of antibiotics results in the inhibition of susceptible organisms while selecting for the resistant ones, agricultural use is contributing substantially to the emergence and spread of antibiotic resistance in the environment. So far, scientific focus has predominantly been on the emergence and spread of resistant bacteria and genes into the environment as a result of veterinary treatment, in particular through manure but also through food products and direct animal contact. However, environmental contamination with antibiotic residues could also be an important factor in the selection and dissemination of antibiotic resistant bacteria. The persistence of antibiotics in the environment depends on factors like soil type and climate, but also on physical-chemical characteristics of the different types of antibiotics. Monitoring studies showed that substantial concentrations of antibiotic residues can occur in soil and water, in particular at locations close to intensive animal farming. Little is known about the concentrations that will exert selective pressure on environmental microorganisms and promote persistence or even enrichment of the environmental resistance gene pool. Traditionally, it was assumed that resistance is only induced at concentrations above the minimum inhibitory concentration (MIC). However, recently, evidence is accumulating that selective environments may occur at concentrations down to several hundred-folds below the MIC. However, for most of the antibiotics and environmental conditions, the minimal threshold concentrations that will induce or support propagation of antibiotic resistance in environmental microbes are still undefined. Therefore, more research is needed into the relationship between the concentrations of antibiotic residues in the environment and the prevalence and persistency of environmental antibiotic resistance. First, additional research is needed to determine what antibiotic concentrations still exert pressure on bacteria and can cause persistence or enrichment of resistant bacteria. Furthermore, the fate of antibiotics in the main reservoirs (manure, soil, water) should be studied, including antimicrobially active metabolites and their bioavailability. Finally, transmission of antibiotic compounds between reservoirs should be studied to identify the main reservoirs of interest and define intervening measures.
Antibiotic resistance reservoirs : the cases of sponge and human gut microbiota
Versluis, Dennis - \ 2016
University. Promotor(en): Hauke Smidt, co-promotor(en): Mark van Passel; Detmer Sipkema. - Wageningen : Wageningen University - ISBN 9789462579057 - 197
antibiotic resistance - reservoirs - intestinal microorganisms - luffa - forest soils - sediment - escherichia coli - penicillium - faecal examination - antibioticaresistentie - darmmicro-organismen - bosgronden - fecesonderzoek

One of the major threats to human health in the 21st century is the emergence of pathogenic bacteria that are resistant to multiple antibiotics, thereby limiting treatment options. An important route through which pathogens become resistant is via acquisition of resistance genes from environmental and human-associated bacteria. Yet, it is poorly understood to what extent and by what mechanisms these so-called reservoirs contribute to emerging resistance. Therefore, the work described in this thesis focussed on generating novel insights into different niches as sources of resistance, with a particular focus on the human gut microbiota as well as on microbial communities associated with marine sponges, especially because the latter have been described as one of the richest sources of bioactive secondary metabolites, including a broad range of antimicrobials. Cultivation-based methods were complemented with culture-independent approaches in order to study bacterial taxa that are not readily cultivated.

Using metatranscriptomics it was found that clinically relevant antibiotic resistance genes are expressed in a broad range of environmental niches including human, mouse and pig gut microbiota, sea bacterioplankton, a marine sponge, forest soil and sub-seafloor sediment. The diversity of resistance gene transcripts differed greatly per niche indicating that the environment contains a rich reservoir of functional resistance that could be accessible by pathogens. Even though resistance gene expression might be linked to the presence of natural antibiotics, we did not detect expression of the corresponding secondary metabolite biosynthesis clusters.

Thirty-one antibiotic-resistant bacteria, amongst which three belonging to potentially novel Flavobacteriaceae spp., were isolated from the Mediterranean sponges Aplysina aerophoba, Corticium candelabrum and Petrosia ficiformis. Isolates were identified in a high throughput manner by double-barcoded 16S rRNA gene amplicon sequencing. Furthermore, analysis of sponge tissue-derived bacterial biomass growing on agar media showed that many novel bacterial taxa can still be isolated by conventional cultivation methods. Genomic DNA from the 31 antibiotic resistant bacteria was interrogated with respect to the presence of active resistance genes by functional metagenomics. In addition, we also screened metagenomic libraries prepared from DNA directly isolated from sponge tissue in order to circumvent the need for cultivation. In total, 37 unique resistance genes were identified, and the predicted gene products of 15 of these shared <90% amino acid identity with known gene products. One resistance gene (blaPSV-1), which was classified into a new β-lactamase family, was found to be exclusive to the marine specific genus Pseudovibrio. These findings raised questions as to the functional roles of these genes in sponges, but more importantly, the functionality of these genes in E. coli shows that they can potentially be harnessed by phylogenetically distinct bacteria in other environments, including human pathogens. As such, it is a wake-up call as to the significance of marine resistance reservoirs.

Pseudovibrio, a genus of α-Proteobacteria, was studied in more detail by comparative genomics as it comprises bacteria that potentially play a role as sponge symbionts and marine hubs of antibiotics resistance. Based on gene content, members of the genus Pseudovibrio were found to cluster by sponge sampling location indicating geographic speciation. Furthermore, Pseudovibrio spp. isolated from sponges near the Spanish coast clustered by sponge, suggesting host-specific colonization or adaptation. Strong support for Pseudovibrio spp. forming symbiotic relations with sponges came from the presence of a plethora of (predicted) conserved symbiosis-related functions in their genomes.

A final study aimed to isolate novel antibiotic resistant reservoir species from the human gut microbiota using a targeted approach. Faecal samples from hospitalized patients that received Selective Digestive Decontamination (SDD), a prophylactic treatment with a cocktail of different antibiotics (tobramycin, polymyxin E, amphotericin B and cefotaxime), were inoculated anaerobically on agar media, after which bacterial biomass was analysed by 16S rRNA gene amplicon sequencing. Six novel taxa were identified that, based on their growth on media supplemented with the SDD antibiotics, could serve as clinically relevant reservoirs of antibiotic resistance. For one of these six taxa a member was obtained in pure culture by targeted isolation. The abundance of antibiotic resistant uncultivated taxa in the human gut microbiota warrants further research as to their potential roles in resistance dissemination.

In conclusion, this thesis provides deeper insights into different environmental niches as reservoirs of antibiotic resistance. The results can serve to prime and inspire future research.

Akkermansia species : phylogeny, physiology and comparative genomics
Ouwerkerk, J.P. - \ 2016
University. Promotor(en): Willem de Vos, co-promotor(en): Clara Belzer. - Wageningen : Wageningen University - ISBN 9789462577411 - 178 p.
akkermansia - akkermansia muciniphila - gastrointestinal microbiota - phylogeny - physiology - genomics - dna sequencing - nucleotide sequences - transcriptomes - antibiotic resistance - genome annotation - microbiota van het spijsverteringskanaal - fylogenie - fysiologie - genomica - dna-sequencing - nucleotidenvolgordes - transcriptomen - antibioticaresistentie - genoomannotatie

The gastrointestinal tract is lined with a mucus layer, which is colonized by a distinct mucosal microbial population. The anaerobic gut bacterium Akkermansia muciniphila is a well-described member of the mucosal microbiota and has been shown to be a human gut symbiont. In the mucus layer this gut symbiont is likely exposed to the oxygen that diffuses from mucosal epithelial cells. We showed that A. muciniphila has an active detoxification system to cope with reactive oxygen species and can use oxygen for respiration at nanomolar oxygen concentrations, with cytochrome bd as terminal oxidase.

Until now, the type strain A. muciniphila MucT was the only cultured representative of this species. We isolated and characterized six new A. muciniphila strains from faecal samples of four different human subjects. These A. muciniphila strains showed minimal genomic and physiologic divergence while retaining their mucin degrading and utilisation capacities. Apart from the human gastrointestinal tract, we detected Akkermansia species in intestinal samples of numerous mammals. An additional ten new A. muciniphila strains were isolated from seven different mammalian species and showed high genomic and physiologic similarity to type strain A. muciniphila MucT. Apart from Akkermansia species, other Verrucomicrobia were identified within the gastrointestinal tract of non-human mammals. Furthermore, we obtained an Akkermansia isolate from the reticulated python, which had a similar mucin degrading capacity as the human strain A. muciniphila MucT but showed more efficient galactose utilization. On the basis of further phylogenetic, physiological, and genomic characterisations, strain PytT was found to represent a novel species within the genus Akkermansia, for which the name Akkermansia glycaniphilus sp. nov. is proposed.

Overall, A. muciniphila strains isolated from intestinal samples of human and other mammals show very limited genomic and physiologic divergence. This together with the widely-spread global presence of A. muciniphila and the dependence on mucin for optimal growth, points towards a conserved symbiosis. This conserved symbiosis might be indicative for the beneficial role of this organism in respect to the host metabolic health. This is in line with the observation that A. muciniphila has been negatively associated with obesity and its associated metabolic disorders.

In mice, treatment with viable A. muciniphila cells reversed high-fat diet-induced obesity. We described a scalable workflow for the preparation and preservation of high numbers of viable cells of A. muciniphila under strict anaerobic conditions for therapeutic interventions. Moreover, we developed various quality assessment and control procedures aimed to ensure the use of viable cells of A. muciniphila at any location in the world. These viable cells were used in a pilot study in humans in which no adverse events were observed. This is promising for future applications of A. muciniphila as a new therapeutic, leading towards the potential treatment of unhealthy states of the microbiota.

Assessing the effects of chemicals on aquatic microbial ecosystems
Rocha Dimitrov, M. - \ 2016
University. Promotor(en): Hauke Smidt; Paul van den Brink. - Wageningen : Wageningen University - ISBN 9789462576667 - 264 p.
aquatic ecosystems - microorganisms - macroinvertebrates - microbial ecology - aquatic fungi - chemicals - tebuconazole - fungicide residues - pesticides - marine sediments - toxicity - enrofloxacin - fluoroquinolones - zooplankton - phytoplankton - antibiotic resistance - periphyton - bacteria - ecological risk assessment - aquatische ecosystemen - micro-organismen - macroinvertebraten - microbiële ecologie - waterschimmels - chemicaliën - tebuconazool - fungicidenresiduen - pesticiden - mariene sedimenten - toxiciteit - enrofloxacine - fluoroquinolonen - zoöplankton - fytoplankton - antibioticaresistentie - perifyton - bacteriën - ecologische risicoschatting
Transmission of antibiotic resistance from animals to humans : Broilers as a reservoir of ESBL-producing bacteria
Huijbers, P.M.C. - \ 2016
University. Promotor(en): Mart de Jong; Lisette Graat; E. van Duijkeren. - Wageningen : Wageningen University - ISBN 9789462576216 - 156 p.
broilers - man - disease transmission - antibiotic resistance - bacteria - enterobacteriaceae - poultry farming - epidemiology - vleeskuikens - mens - ziekteoverdracht - antibioticaresistentie - bacteriën - pluimveehouderij - epidemiologie

Huijbers, P.M.C. (2016). Transmission of antibiotic resistance from animals to humans: Broilers as a reservoir of ESBL-producing bacteria. PhD thesis, Wageningen University, Wageningen, the Netherlands.

Antibiotic resistance in animals becomes a public health issue when there is transmission of antibiotic resistant bacteria, or their resistance genes, from animals to humans. β-lactam antibiotics are critically important for the treatment of human bacterial infections. Resistance to this class of antibiotics, mediated by extended-spectrum β-lactamases (ESBL) has emerged. Broilers might contribute to transmission to humans due to the high prevalence of ESBL-producing Enterobacteriaceae among their intestinal biome, compared to other livestock species, companion animals, and wildlife. Transmission to humans might occur via the food chain, by direct contact or via the environment. The aim was to investigate transmission of antibiotic resistant bacteria between animals and humans, and more specifically transmission of ESBL-producing E. coli between broilers, and between broilers and humans in varying degrees of contact with these animals. Systematically collected and categorised evidence from literature showed that clinically relevant antibiotic resistant bacteria were present in the natural environment, that is in soil, water, air and wildlife. It was therefore hypothesised that humans in areas with high broiler densities might have an increased risk for carriage of ESBL-producing Enterobacteriaceae. This hypothesis was rejected, as the observed risk was lower for these individuals. The situation might be different for individuals living on broiler farms as ESBL-producing E. coli were detected on all investigated farms. Among broilers, the within farm prevalence approached 100%, and there was no difference between conventional and organic farms at five weeks, i.e. just before slaughter on conventional farms. On organic farms, the prevalence decreased to 80.0% at 70 days, i.e. slaughter age. Not only transmission to humans via the farm environment, but close physical contact with broilers might, therefore, lead to increased risk for carriage. Prevalence among farmers, their family members and employees on both conventional (19.1%) and organic (18.5%) broiler farms was higher compared to humans in the general population (5.1%). Moreover, people in close contact with live broilers showed the highest risk (27.1 vs. 14.3%). Evidence for clonal transmission of ESBL-producing E. coli between humans and broilers was found on conventional farms, and horizontal gene transfer was suspected on both conventional and organic farms. Even without selection pressure from antibiotics ESBL-producing E. coli were able to transmit and persist in an organic broiler flock, which shows that broilers form a reservoir of antibiotic resistance genes. This leads to an increased risk of carriage of humans on farms through direct contact with broilers and possibly via the direct farm environment. As only a very small percentage of the general population is exposed to live broilers, direct contact with broilers does not appear to be important for carriage in the general human population.

Antibiotics in the chain : analyses of feces to study the life-cycle of antibiotics
Stolker, A.A.M. ; Kang, J.W. ; Lee, K.J. ; Park, H.C. ; So, B. ; Wegh, R.S. ; Berendsen, B.J.A. ; Zuidema, T. - \ 2014
feces - antibiotica - antibioticaresistentie - dierhouderij - vleesproductie - monitoring - faeces - antibiotics - antibiotic resistance - animal husbandry - meat production
To prevent further dissemination of resistance, the use of antimicrobial compounds in animal husbandry should be decreased. Therefore, instead of monitoring food products related to MRL regulations, antibiotic usage in general should be monitored in an effective way. The analysis of feces is a promising option.
Veel soorten antibiotica in mest gevonden
Sikkema, A. ; Mevius, D.J. - \ 2014
Resource: weekblad voor Wageningen UR 9 (2014)6. - ISSN 1874-3625 - p. 10 - 10.
dierlijke meststoffen - antibiotica - antibioticumresiduen - antibioticaresistentie - varkensmest - kalveren - mest - animal manures - antibiotics - antibiotic residues - antibiotic resistance - pig manure - calves - manures
Het Rikilt vindt met nieuwe methode veel antibioticasoorten in dierlijke mest. Het gevaar voor de volksgezondheid is nog onbekend.
1Health4Food : focus op gezondheid mens-dier
Kimman, T.G. ; Mevius, D.J. ; Antonis, A.F.G. ; Parée, P. - \ 2014
V-focus 2014 (2014)1. - ISSN 1574-1575 - p. 22 - 24.
veehouderij - dierlijke productie - diergezondheid - volksgezondheid - wetenschappelijk onderzoek - onderzoeksprojecten - diagnostiek - antibioticaresistentie - volksgezondheidsbevordering - verbreed spectrum bèta-lactamases - immuniteit - immuunsysteem - immunologie - voedselveiligheid - voeding en gezondheid - mens-dier relaties - livestock farming - animal production - animal health - public health - scientific research - research projects - diagnostics - antibiotic resistance - sanitation - extended spectrum beta-lactamases - immunity - immune system - immunology - food safety - nutrition and health - human-animal relationships
1Health4Food is een ambitieus onderzoeksprogramma op het gebied van dier- en volksgezondheid. Het landbouwbedrijfsleven heeft in sterke mate bepaald waar de prioriteiten moeten liggen: bij de ESBL’s en de snelle diagnostiek. Binnen 1Health4Food wordt kennis ontwikkeld voor meerdere sectoren, kennis die veehouders en hun adviseurs, zoals dierenartsen, in staat stellen om rendabel te produceren op een wijze die ook veilig is voor de mens. De ambitie is om in de toekomst gezamenlijk een gezonde en veilige veehouderij te realiseren.
Antibiotica in grond en water : via plant weer in mens en dier
Verwer, C.M. ; Smolders, E.A.A. ; Vijver, L.P.L. van de; Eekeren, N.J.M. van; Hospers-Brands, A.J.T.M. ; Marel, A. van der - \ 2013
V-focus 10 (2013)1. - ISSN 1574-1575 - p. 34 - 35.
veevoeder - bijproducten - dierlijke meststoffen - antibioticumresiduen - antibioticaresistentie - risicoschatting - voedselketens - kennisniveau - dierenwelzijn - fodder - byproducts - animal manures - antibiotic residues - antibiotic resistance - risk assessment - food chains - knowledge level - animal welfare
Residuen van antibiotica en resistente bacteriën zijn niet alleen rechtstreeks een risico voor mens en dier, maar kunnen ook via de grond en het oppervlaktewater in planten terechtkomen. Zo kunnen ze indirect ook een risico vormen voor mens en dier. Dit spoor in de voedselketen is in de discussie over het gebruik van antibiotica en de gevolgen hiervan tot nu toe onderbelicht. Bij het Louis Bolk Instituut is een project gestart, waarin de verschillende sporen van overdracht in de voedselketen in kaart gebracht worden en waarin nog aanwezige hiaten in de kennis opgespoord en mogelijk gedicht kunnen worden.
Antibioticagebruik hangt samen met veehouder en bedrijfsvoering
Kuipers, A. ; Wemmenhove, H. ; Koops, W. - \ 2013
V-focus 10 (2013)1. - ISSN 1574-1575 - p. 36 - 38.
melkveehouderij - antibiotica - dosering - antibioticaresistentie - milieueffect - milieuhygiëne - agrarische bedrijfsvoering - dairy farming - antibiotics - dosage - antibiotic resistance - environmental impact - environmental hygiene - farm management
Het antibioticagebruik werd in de periode 2005 t/m 2011 in kaart gebracht. Er is veel variatie tussen bedrijven. Vanaf 2009 is een lichte daling te zien, met name voor toepassing tegen aandoeningen anders dan mastitis. De melkveehouder met een wat groter quotum, lager celgetal en hogere diergezondheidsstatus gebruikte meer. Deze melkveehouder heeft een goede band met de dierenarts, onderneemt snel actie qua diergezondheid, zoemt in op de omgeving, maar is niet zo bezig met regelgeving. Conclusie: de veehouder, die als ‘succesvol en ondernemend’ wordt gezien, gebruikte meer antibiotica.
Trends in veterinary antibiotic use in the Netherlands 2004-2012
Bondt, N. ; Puister-Jansen, L.F. ; Ge, L. ; Veen, H.B. van der; Bergevoet, R.H.M. ; Douma, B.E. ; Vliet, A.L.J. van; Wehling, K.W. - \ 2012
Den Haag : LEI Wageningen UR (LEI 12-109) - 26
veehouderij - varkenshouderij - pluimveehouderij - rundveehouderij - antibiotica - dosering - monitoring - antibioticaresistentie - livestock farming - pig farming - poultry farming - cattle husbandry - antibiotics - dosage - antibiotic resistance
The objective of this study is to obtain detailed insight into the trends in the exposure of farm animals to antibiotics. This is done by monitoring both overall sales data at the national level and usage data per animal species: pigs, poultry, veal calves, other cattle and sheep.
Antibioticagebruik eenvoudig te vergelijken op website
Puister-Jansen, L.F. - \ 2012
Veehouder en Dierenarts 26 (2012)2. - ISSN 1381-8007 - p. 14 - 15.
melkveehouderij - antibiotica - dosering - antibioticaresistentie - dairy farming - antibiotics - dosage - antibiotic resistance
De antibioticawijzer is een handig hulpmiddel om inzicht te krijgen in het antibioticagebruik op uw bedrijf. De antibioticawijzer vindt u op
Antibioticaresistentie in de biologische varkenshouderij : komt MRSA ook voor bij biologische varkens en hun verzorgers?
Vijver, L.P.L. van de; Verwer, C. ; Bondt, N. ; Mevius, D.J. - \ 2012
Driebergen : Louis Bolk Instituut (Publicatie / Louis Bolk Instituut nr. 2012-019 GV) - 35
meticilline resistente staphylococcus aureus - antibioticaresistentie - varkens - varkenshouderij - biologische landbouw - bemonsteren - methicillin-resistant staphylococcus aureus - antibiotic resistance - pigs - pig farming - organic farming - sampling
This research confirms the expectation that within the organic pig farming the prevalence of MRSA is lower than in conventional pig farming. However, the problem of MRSA does exist in organic pig farming as well, and therefore it is also important in organic pig farming to pay attention to reducing the risk factors for the spread of MRSA.
Antibioticagebruik en veehouderij: ESBL en MRSA in dieren en de genomen controlemaatregelen
Mevius, D.J. - \ 2012
Infectieziekten bulletin 23 (2012)3. - ISSN 0925-711X - p. 82 - 83.
veehouderij - antibiotica - dosering - antibioticaresistentie - volksgezondheidsbevordering - landbouwbeleid - livestock farming - antibiotics - dosage - antibiotic resistance - sanitation - agricultural policy
Het antibioticagebruik in Nederlandse veehouderij is hoog, zeker in vergelijking met de humane sector. Daardoor zijn ook de resistentieniveaus in dieren in de veehouderij hoog. De bezorgdheid over de gevolgen hiervan voor de volksgezondheid heeft geleid tot een aantal maatregelen, waaronder de reductiedoelstellingen in antibioticumgebruik (20% in 2011 en 50% in 2013). Het streefcijfer voor 2011 is bereikt, maar voor het oplossen van de huidige en toekomstige bedreigingen door multiresistente organismen in (voedselproducerende) dieren voor de volksgezondheid is een aanzienlijke verdere afname in gebruik noodzakelijk en op de langere termijn een verandering in de dierlijke productiesystemen.
Een risicoprofiel voor MRSA en ESBL
Mevius, D.J. - \ 2012
Kennis Online 9 (2012)april. - p. 18 - 18.
antibioticaresistentie - volksgezondheid - diergezondheid - staphylococcus aureus - zoönosen - bacteriën - antibiotic resistance - public health - animal health - zoonoses - bacteria
Het Centraal Veterinair Instituut (CVI) van Wageningen UR, onderzoekt de ontwikkeling van de antibioticaresistente MRSA-bacterie en ESBL-vormende bacteriën en de gevaren voor de volksgezondheid. Want de resistentie bacteriën kunnen zich op vele manieren verspreiden.
Antibioticagebruik deels afhankelijk van bedrijfsvoering
Kuipers, A. ; Ensing, C. ; Koops, W.J. - \ 2012
V-focus 9 (2012)1. - ISSN 1574-1575 - p. 28 - 30.
melkveehouderij - antibiotica - dosering - antibioticaresistentie - agrarische bedrijfsvoering - bedrijfsvergelijking in de landbouw - dairy farming - antibiotics - dosage - antibiotic resistance - farm management - farm comparisons
Het antibioticagebruik op bedrijven varieert in hoge mate. De verschillen blijken deels afhankelijk van de bedrijfsvoering. De melkveehouder met een wat groter quotum, lager celgetal en hogere gezondheidsstatus gebruikt meer. Dit is in feite de ‘succesvolle’ veehouder. Dit lijkt dus de groep om op te focussen.
Verminderen antibioticagebruik in de vleeskuikensector : CLEAR Helpdeskvraag 2011
Lourens, A. ; Jansman, A.J.M. ; Rebel, J.M.J. ; Harn, J. van; Veldkamp, T. ; Stockhofe, N. ; Melchior, M.B. ; Emous, R.A. van; Kense, M. - \ 2011
Lelystad : Wageningen UR Livestock Research (Rapport / Wageningen UR Livestock Research 512) - 80
pluimveehouderij - vleeskuikens - antibiotica - dosering - antibioticaresistentie - agrarische bedrijfsvoering - agrarische productiesystemen - dierenwelzijn - diergezondheid - dierlijke productie - poultry farming - broilers - antibiotics - dosage - antibiotic resistance - farm management - agricultural production systems - animal welfare - animal health - animal production
Questions from participants and advisors in the CLEAR project with regard to reduction of the use of antibiotics in the broiler sector are answered. Advice and suggestions for further research are given.
Inzicht in zes jaar antibioticagebruik
Kuipers, A. ; Wemmenhove, H. - \ 2011
Veeteelt september (2011). - ISSN 0168-7565 - p. 13 - 14.
melkveehouderij - antibiotica - dosering - antibioticaresistentie - agrarische bedrijfsvoering - dairy farming - antibiotics - dosage - antibiotic resistance - farm management
Het project ‘Transparant en efficiënt medicijngebruik’ bracht gedurende zes jaar het antibioticagebruik in kaart. Bij melkvee gaat ongeveer zeventig procent van de gebruikte antibiotica naar de uier. Zeventien procent van het totale gebruik bestaat uit de zogenaamde derde- en vierdegeneratiemiddelen.
Veterinary antibiotic usage in the Netherlands in 2010
Bondt, N. ; Puister-Jansen, L.F. ; Veen, H.B. van der; Bergevoet, R.H.M. ; Douma, B.E. ; Vliet, A.L.J. van; Wehling, K.W. - \ 2011
Wageningen : Wageningen UR - 17
veehouderij - antibiotica - toepassing - marktonderzoek - overheidsbeleid - antibioticaresistentie - livestock farming - antibiotics - application - market research - government policy - antibiotic resistance
The objective of this study is to obtain detailed insight into the exposure of farm animals to antibiotics, by monitoring both sales data at the national level and more specifically data per animal species. The results of the study can be used by the Ministry of Economic Affairs, Agriculture and Innovation for policy evaluation. In addition, the usage data might play a role in explaining trends in resistance that have become apparent.
Faagtherapie is alternatief voor antibiotica
Willemsen, P.T.J. - \ 2011
Kennis Online 2011 (2011)14 juni. - p. 21 - 21.
veehouderij - antibioticaresistentie - pluimveehouderij - kuikens - bacterieziekten - bacteriofagen - antibacteriële eigenschappen - livestock farming - antibiotic resistance - poultry farming - chicks - bacterial diseases - bacteriophages - antibacterial properties
De zoektocht naar alternatieven voor het gebruik van antibiotica in de veehouderij is nog steeds urgent. Bacteriofagen kunnen uitkomst bieden. De faagtherapie bleek o.a. succesvol in een proef met 120 kuikens, waarvan de helft besmet was. Na toediening was de ziekteverwekkende bacterie voldoende gereduceerd.
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