Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

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Groen in de stad : Waterhuishouding
Hiemstra, J.A. - \ 2018
Wageningen University & Research - 6 p.
greening - water harvesting - biodiversity - climate - plantations - air quality - drought - health - well-being
Groen in de stad : Luchtkwaliteit
Hiemstra, J.A. - \ 2018
Wageningen University & Research - 6 p.
greening - plantations - air quality - water harvesting - health - environment - climate
Groen in de stad : Biodiversiteit
Hiemstra, J.A. ; Kuik, A.J. van; Coolen, Silvia - \ 2018
Wageningen University & Research - 6 p.
biodiversity - plantations - greening - health - well-being - urban areas
Groene dagbesteding in de stad: een levendige plek voor mensen met dementie : Factsheet
Buist, Y. ; Bruin, S. de; Vaandrager, L. ; Hassink, J. - \ 2018
Wageningen : Wageningen University & Research - 17 p.
health - well-being - nature - agriculture - participation
Aan de slag met groene dagbesteding in de stad voor mensen met dementie
Hassink, J. ; Vaandrager, L. ; Bruin, S. de; Buist, Y. - \ 2018
Wageningen : Wageningen University & Research - 7 p.
participation - health - well-being - care - greening - nature
An integrated look at the effect of structure on nutrient bioavailability in plant foods
Capuano, Edoardo ; Pellegrini, Nicoletta - \ 2018
Journal of the Science of Food and Agriculture (2018). - ISSN 0022-5142
bioavailability - digestion - food matrix - health - structure

The true bioavailability of a nutrient being intrinsically coupled to the specific food matrix in which it occurs remains poorly considered in nutrition science. During digestion, the food matrix and, in particular, the structure of food modulate the extent and kinetics to which nutrients and bioactive compounds make themselves available for absorption. In this perspective, we describe an integrated look at the effect of structure on nutrient bioavailability in plant foods. Based on this integrated look, cell wall integrity and the particle size of the plant material during its transit in the small intestine determine the bioavailability of plant nutrients; in turn, cell wall integrity and particle size are determined by the level of oral processing and, accordingly, what subsequently escapes digestion in the upper intestine and is utilized by colon microbiota. Ultimately, the effect on nutrient digestion is linked to food structure through each step of digestion. A consideration of the structure rather than just the composition of foods opens up possibilities for the design of healthier foods.

Zieleń: nie tylko piękna i korzystna dla zdrowia : Wartość dodana zieleni w środowisku miejskim
Hiemstra, J.A. ; Vries, S. de; Spijker, J.H. ; Zbiorowa, P. - \ 2018
Wageningen : Wageningen University & Research - 6 p.
huisvesting - beplantingen - onderwijs - welzijn - gezondheid - bewoning - openbaar groen - arbeid (werk) - tuinen - tuinen bij het huis - publieke tuinen - stadslandbouw - housing - plantations - education - well-being - health - tenancy - public green areas - labour - gardens - domestic gardens - public gardens - urban agriculture

Factsheet Betekenis van zorgboerderijen voor verschillende doelgroepen
Hassink, J. ; Bruin, Simone de; Verbeek, Hilde ; Buist, Yvette - \ 2018
Wageningen : Wageningen University & Research - 7 p.
well-being - care - greening - urban areas - health - education - cooperation - social care farms
Plant power
Hermans, Tia - \ 2018
plantations - air quality - health - well-being - labour - offices - care - climate

Een plant op je bureau is gezond, zeggen ze. Het groen zou wonderen doen voor het binnenklimaat en de werklust. Bewijzen zijn er echter nog nauwelijks. Een proef op kantoren en in zorginstellingen moet nu uitsluitsel geven.

Zeven redenen om te investeren in een groene stad : Longread
Hattum, T. van; Stuiver, M. ; Spijker, J.H. ; Visschedijk, P.A.M. ; Vries, S. de; Snep, R.P.H. ; Jacobs, C.M.J. - \ 2017
Wageningen University and Research
green roofs - green walls - plantations - parks - nature - well-being - urban areas - health
Dossier Veranderend eetpatroon
Mols, H. ; Kortstee, H.J.M. ; Warnaar, M. ; Methorst, B. ; Sijtsema, S.J. ; Dagevos, H. ; Onwezen, M.C. ; Ingenbleek, P.T.M. ; Genderen, R.A. van - \ 2017
Wageningen : Groen Kennisnet
nutrition - feeding habits - consumers - consumption - proteins - health
De trends in voedselland volgen elkaar in snel tempo op. Gezond, duurzaam, natuurlijk, gemak, out of home, fairtrade zijn trenditems die we in kranten, vakbladen en actualiteitenrubrieken, vlogs en blogs dagelijks kunnen ervaren.
Maar leidt het ook tot gewenste veranderingen in de voedselkeuze van de consument naar een gezonder en duurzamer eetpatroon.
De groene agenda: Ontwerptool Groene Gezonde Stad
Snep, Robbert - \ 2017
urban areas - water harvesting - climate - projects - plants - health - urban parks

De Ontwerptool Groene Gezonde Stad is een tool in ontwikkeling die het effectief gebruik van stadsgroen door planners, ontwerpers, ontwikkelaars, hoveniers en groenvoorzieners ten behoeve van maatschappelijke doelstellingen (gezonde woon-/werk-/leefomgeving) moet stimuleren. De plek die groen nu inneemt in het proces is redelijk achteraan. Het doel is dat planners, ontwerpers, ontwikkelaars, grondeigenaren etc. het groen meenemen in het ontwerpproces. Dan wordt de vraag naar groen en de kwaliteit van groen ook beter. Professionals krijgen met via de tool beter inzicht in waar en welk groen welk gezondheidseffect op welk doelgroep heeft, en worden daarmee uitgenodigd die kennis te benutten in hun plannen en projecten. Dit levert een gezondere stedelijke samenleving op, en maakt dat de economische waarde van het groen duidelijker wordt meegenomen in de besluitvorming over de inrichting en het beheer van de stad.

Non-digestible polysaccharides to support the intestinal immune barrier: in vitro models to unravel molecular mechanisms
Tang, Yongfu - \ 2017
University. Promotor(en): Harry Wichers, co-promotor(en): Jurriaan Mes; Coen Govers. - Wageningen : Wageningen University - ISBN 9789463437134 - 166
polysaccharides - health - immunomodulatory properties - homeostasis - intestinal diseases - human nutrition research - polysacchariden - gezondheid - immunomodulerende eigenschappen - homeostase - darmziekten - voedingsonderzoek bij de mens

Non-digestible polysaccharides (NDPs) are considered as important ingredients to support health. Among these health effects, immunomodulatory effects raised interests in the past decade. The intestine is the primary organ that interact with NDPs. The intestinal epithelial cells (IECs) form a dynamic physical barrier and together with associated immune cells determine for a large part our immune homeostasis. Studying the direct interaction between NDPs and intestinal and immune cells could help us to uncover the mechanism by which NDPs exert immunomodulatory effects and how NDPs can differ in this activity. In this thesis, we investigated the immunomodulatory effects of NDPs through interaction with intestinal immune cells using in vitro methods in order to characterise the NDPs and preselect NDPs with differential activity for further in vivo evaluations.

The intestinal immune barrier is formed by various IECs and immune cells, which are introduced and their specific functions discussed in Chapter 1. NDPs could interact directly with both IECs and immune cells that sample in or from the lumen. The majority of IECs are enterocytes and most relevant immune cells responsible for sampling in the lumen have been characterised as macrophages, which leads us to focus on these cell types by in vitro approaches. In addition, basic information on NDPs and current status on health effects of NDPs both in vitro and in vivo are discussed.

In Chapter 2, the direct response of IEC to NDPs stimulation was investigated. IECs form the largest surface of the body that, with a crucial role as barrier also, perform a role in signalling towards immune cells. We used 21-day transwell cultured Caco-2 to resemble the small intestinal enterocytes that form largest part of this intestinal layer. We first characterized the chemical composition of five NDPs which revealed different mono sugar composition, linkages of backbone and side chains and a wide range of MW (from 17 KDa to 2100 KDa). The NDPs could reduce translocation of FITC-Dextran of 4 kDa across the epithelial layer, potentially through physical interference. Gene expression analysis indicated the induction of unique gene expression characteristics in Caco-2 cells upon exposure to different NDPs. An arabinoxylan preparation from wheat and a lentinan-containing extract from shiitake mushrooms showed upregulation of gene expression of the NF-κB family and chemokines CCL20 and CXCL10. Besides these immune related changes by some NDPs, we also observed changes in receptor expression (like TLR2, CD14 and GPCRs) and other pathways, amongst which the cholesterol biosynthesis pathway.

Macrophages, as the resident population of immune cells penetrating between or associating with close contact with the IECs, are generally classified as inflammatory (M1) or as tolerant (M2) macrophages. In Chapter 3, we set up a macrophage differentiation method based on primary blood cells and selected and validated M1 and M2 specific gene expression markers. Next, we analysed the effect when macrophages are exposed to NDPs and compared the resulting macrophages with M1 and M2 macrophages. Based on M1 and M2 markers we identified an alternative subset that we named MNDP. This MNDP was further studied by microarray analysis and revealed a commonly modulated set of genes, involved in migration, metabolic processes, cell cycle, and inflammatory immune function.

In Chapter 4, we further functionally characterize these MNDP in comparison to M1 and M2 macrophages based on a set of functional assays. NDP-treated macrophages showed no IDO activity and showed an inhibited antigen uptake and processing capacity compared to M1 and M2 macrophages. Also their phagocytic capacity was reduced compared to both M1 and M2 macrophages. Furthermore, the alternative expression pattern for NDP-treated macrophages, as demonstrated by gene expression, was confirmed by protein measurements. The signature mix of the chemokines CCL1, CCL5, CCL20, CCL24, CXCL8, and IL1β secreted by MNDP, and in particular when macrophages were treated with Naxus, was shown to induce a recruitment of monocytes.

As macrophage plasticity could be essential for intestinal immune homeostasis, resolving activity of inflammatory responses upon a challenge is important. Besides, redirecting differentiation and function of tolerant macrophages can also be beneficial to the intestinal immune status. In Chapter 5, we analysed plasticity of M1 and M2 macrophages to NDPs exposure. Macrophage plasticity was demonstrated as M1 and M2 could be skewed to an alternative subset indicated by a dedicated set of gene expression markers, selected to characterize M1, M2 and MNDP macrophages. In addition, phagocytosis and antigen processing capacity of both M1 and M2 were decreased by the NDP Naxus. Besides, Naxus could change the secretion of cytokines by macrophages that previously were differentiated towards M1 and M2. For M2, this resulted in an increase of recruitment of monocytes by M2 macrophages.

In Chapter 6, we discussed the important findings in each chapter of this thesis together with current literature, and gave a general perspective on this research line focussing on the immunomodulating activity of NDPs and the direction for future research. We suggested NDPs in terms of Naxus as candidate for guiding investigations in ex vivo and in vivo studies for immunomodulation of intestinal disease.

Groene initiatieven in de stad : handelingsperspectief provincies voor het stimuleren van maatschappelijke betrokkenheid bij groen in de stad
Dijkshoorn-Dekker, M.W.C. ; Soma, K. ; Blaeij, A.T. - \ 2017
Wageningen : Wageningen Economic Research (Wageningen Economic Research rapport 2017-012) - ISBN 9789463438032 - 47
participatie - groene gevels - groene daken - planten - gezondheid - luchtkwaliteit - communicatie - klimaat - regenwateropvang - participation - green walls - green roofs - plants - health - air quality - communication - climate - water harvesting
Metropolitan Solutions: Helende tuinen
Jansma, J.E. - \ 2017
WUR
tuinen - gezondheid - planten - herstellen - welzijn - participatie - gardens - health - plants - reconditioning - well-being - participation
Voldoende bewegen en gezond eten helpt bij het herstel van ziektes of verbetert de kwaliteit van leven bij chronische ziektes. Helaas lukt het lang niet iedereen om dit toe te passen. Daarom zijn Wageningen University & Research (Division of Human Nutrition, Wageningen Plant Research, Rural Sociology) en AMS institute binnen Flevo Campus het pilotproject Helende tuinen gestart om te onderzoeken of we mensen een manier kunnen bieden die wel makkelijk is om in te passen in je leven. We laten ze samen tuinieren. Jan Eelco Jansma, onderzoeker stad-landrelaties bij Wageningen University & Research, vertelt erover in deze video.
Greenery: more than beauty and health : A summary of the benefits of greenery on health, productivity, performance and well-being
Hiemstra, J.A. ; Vries, S. de; Spijker, J.H. - \ 2017
Wageningen : Wageningen University & Research - 6 p.
health - well-being - plants - trees - reconditioning - air quality - biodiversity - air conditioning - learning - labour - green roofs - green walls - gezondheid - welzijn - planten - bomen - herstellen - luchtkwaliteit - biodiversiteit - klimaatregeling - leren - arbeid (werk) - groene daken - groene gevels
Greenery in our living environment is beneficial for more than just our health and well-being. It facilitates water management and stimulates biodiversity in built-up areas, and it can also reduce the effects of noise pollution. Greenery also has a positive impact on the property value of homes and offices. This document provides general information on the benefits of greenery, supplementary to the detailed fact sheets on how greenery can improve health and well-being in Residential, Professional, Educational and Healthcare contexts.
Greenery and Education : A summary of the positive effects of greenery on well-being in educational environments
Hiemstra, J.A. ; Vries, S. de; Spijker, J.H. - \ 2017
Wageningen : Wageningen University & Research - 7 p.
learning - children - universities - climate - educational institutions - education - social welfare - well-being - health - pupils - students - schools - leren - kinderen - universiteiten - klimaat - onderwijsinstellingen - onderwijs - sociaal welzijn - welzijn - gezondheid - leerlingen - studenten - scholen
Greenery in and around schools, childcare centres and on campuses is good for the climate at education institutions, both inside and out. It has a positive effect on the health and general well-being of students and staff alike, improving student performance and their ability to concentrate, as well as fostering the social climate. This document provides information on the benefits of greenery in relation to education and well-being, including references to scientific literature. It concludes with some tips on how to ensure the successful and beneficial inclusion of greenery.
Green and Healthcare : A summary of the positive effects of greenery on well-being in recovery environments
Hiemstra, J.A. ; Vries, S. de; Spijker, J.H. - \ 2017
Wageningen : Wageningen University & Research - 6 p.
health - hospitals - patient care - patients - well-being - public green areas - botanical gardens - plantations - social welfare - health indicators - stress - rehabilitation - gezondheid - ziekenhuizen - patiëntenzorg - patiënten - welzijn - openbaar groen - botanische tuinen - beplantingen - sociaal welzijn - gezondheidsindicatoren - herstel
Greenery in and around nursing homes, hospitals and clinics is beneficial for the climate inside and outside the organisation, and has a positive effect on the patients’ state of mind and ability to recover, as well as the general well-being of patients, staff and visitors. This document provides information on the benefits of greenery in relation to recovery and well-being, including references to scientific literature. It concludes with some tips on how to ensure the successful and beneficial inclusion of greenery.
Greenery and Work : A summary of the positive effects of greenery on well-being in working environments
Hiemstra, J.A. ; Vries, S. de; Spijker, J.H. - \ 2017
Wageningen : Wageningen University & Research - 6 p.
offices - work - climate - health - well-being - stress - stress tolerance - labour - kantoren - werk - klimaat - gezondheid - welzijn - stresstolerantie - arbeid (werk)
Greenery in and around offices and other working environments is good for both the indoor and outdoor climate, and has a positive effect on the health and general well-being of employees and visitors. It aids concentration, helps reduce stress and increases staff productivity. This document provides information on the benefits of greenery in relation to work and well-being, including references to scientific literature. It concludes with some tips on how to ensure the successful and beneficial inclusion of greenery.
Are school meals a viable and sustainable tool to improve the healthiness and sustainability of children´s diet and food consumption? A cross-national comparative perspective
Oostindjer, Marije ; Aschemann-Witzel, Jessica ; Wang, Qing ; Skuland, Silje Elisabeth ; Egelandsdal, Bjørg ; Amdam, Gro V. ; Schjøll, Alexander ; Pachucki, Mark C. ; Rozin, Paul ; Stein, Jarrett ; Lengard Almli, Valerie ; Kleef, Ellen van - \ 2017
Critical Reviews in Food Science and Nutrition 57 (2017)18. - ISSN 1040-8398 - p. 3942 - 3958.
children - food behavior - health - learning - School meals - sustainability

There is little agreement among governments, institutions, scientists and food activists as to how to best tackle the challenging issues of health and sustainability in the food sector. This essay discusses the potential of school meals as a platform to promote healthy and sustainable food behavior. School meal programs are of particular interest for improving public diet because they reach children at a population scale across socio-economic classes and for over a decade of their lives, and because food habits of children are more malleable than those of adults. Current research on the history and health implications of school meal programs is reviewed in a cross-national comparative framework, and arguments explored that speak for the need of a new developmental phase of school meals as an integrative learning platform for healthy and sustainable food behavior. Nutritional, social, practical, educational, economical, political, and cultural perspectives and challenges linked to the implementation of healthy and sustainable school meals are discussed. Finally, the need for long-term interventions and evaluations is highlighted and new research directions are proposed.

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