Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Performance of secondary wastewater treatment methods for the removal of contaminants of emerging concern implicated in crop uptake and antibiotic resistance spread : A review
Krzeminski, Pawel ; Tomei, Maria Concetta ; Karaolia, Popi ; Langenhoff, Alette ; Almeida, C.M.R. ; Felis, Ewa ; Gritten, Fanny ; Andersen, Henrik Rasmus ; Fernandes, Telma ; Manaia, Celia M. ; Rizzo, Luigi ; Fatta-Kassinos, Despo - \ 2019
Science of the Total Environment 648 (2019). - ISSN 0048-9697 - p. 1052 - 1081.
Antibiotic resistance - Biological processes - CEC removal - Crop uptake - EU Watch list - Secondary wastewater treatment

Contaminants of emerging concern (CEC) discharged in effluents of wastewater treatment plants (WWTPs), not specifically designed for their removal, pose serious hazards to human health and ecosystems. Their impact is of particular relevance to wastewater disposal and re-use in agricultural settings due to CEC uptake and accumulation in food crops and consequent diffusion into the food-chain. This is the reason why the chemical CEC discussed in this review have been selected considering, besides recalcitrance, frequency of detection and entity of potential hazards, their relevance for crop uptake. Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been included as microbial CEC because of the potential of secondary wastewater treatment to offer conditions favourable to the survival and proliferation of ARB, and dissemination of ARGs. Given the adverse effects of chemical and microbial CEC, their removal is being considered as an additional design criterion, which highlights the necessity of upgrading conventional WWTPs with more effective technologies. In this review, the performance of currently applied biological treatment methods for secondary treatment is analysed. To this end, technological solutions including conventional activated sludge (CAS), membrane bioreactors (MBRs), moving bed biofilm reactors (MBBRs), and nature-based solutions such as constructed wetlands (CWs) are compared for the achievable removal efficiencies of the selected CEC and their potential of acting as reservoirs of ARB&ARGs. With the aim of giving a picture of real systems, this review focuses on data from full-scale and pilot-scale plants treating real urban wastewater. To achieve an integrated assessment, technologies are compared considering also other relevant evaluation parameters such as investment and management costs, complexity of layout and management, present scale of application and need of a post-treatment. Comparison results allow the definition of design and operation strategies for the implementation of CEC removal in WWTPs, when agricultural reuse of effluents is planned.

Assessment of impact of traffic-related air pollution on morbidity and mortality in Copenhagen Municipality and the health gain of reduced exposure
Brønnum-Hansen, Henrik ; Bender, Anne Mette ; Jovanovic Andersen, Zorana ; Sørensen, Jan ; Bønløkke, Jakob Hjort ; Boshuizen, Hendriek ; Becker, Thomas ; Diderichsen, Finn ; Loft, Steffen - \ 2018
Environment International 121 (2018). - ISSN 0160-4120 - p. 973 - 980.
Air pollution - Disease modelling - Effect modelling - Health impact assessment - Prevention

Background: Health impact assessment (HIA) of exposure to air pollution is commonly based on city level (fine) particle concentration and may underestimate health consequences of changing local traffic. Exposure to traffic-related air pollution can be assessed at a high resolution by modelling levels of nitrogen dioxide (NO2), which together with ultrafine particles mainly originate from diesel-powered vehicles in urban areas. The purpose of this study was to estimate the health benefits of reduced exposure to vehicle emissions assessed as NO2 at the residence among the citizens of Copenhagen Municipality, Denmark. Methods: We utilized residential NO2 concentrations modelled by use of chemistry transport models to calculate contributions from emission sources to air pollution. The DYNAMO-HIA model was applied to the population of Copenhagen Municipality by using NO2 concentration estimates combined with demographic data and data from nationwide registers on incidence and prevalence of selected diseases, cause specific mortality, and total mortality of the population of Copenhagen. We used exposure-response functions linking NO2 concentration estimates at the residential address with the risk of diabetes, cardiovascular diseases, and respiratory diseases derived from a large Danish cohort study with the majority of subjects residing in Copenhagen between 1971 and 2010. Different scenarios were modelled to estimate the dynamic impact of NO2 exposure on related diseases and the potential health benefits of lowering the NO2 level in the Copenhagen Municipality. Results: The annual mean NO2 concentration was 19.6 μg/m3 and for 70% of the population the range of exposure was between 15 and 21 μg/m3. If NO2 exposure was reduced to the annual mean rural level of 6 μg/m3, life expectancy in 2040 would increase by one year. The greatest gain in disease-free life expectancy would be lifetime without ischemic heart disease (1.4 years), chronic obstructive pulmonary disease (1.5 years for men and 1.6 years for women), and asthma (1.3 years for men and 1.5 years for women). Lowering NO2 exposure by 20% would increase disease-free life expectancy for the different diseases by 0.3–0.5 years. Using gender specific relative risks affected the results. Conclusions: Reducing the NO2 exposure by controlling traffic-related air pollution reduces the occurrence of some of the most prevalent chronic diseases and increases life expectancy. Such health benefits can be quantified by DYNAMO-HIA in a high resolution exposure modelling. This paper demonstrates how traffic planners can assess health benefits from reduced levels of traffic-related air pollution.

Prediagnostic serum Vitamin D levels and the risk of Crohn's disease and ulcerative colitis in european populations : A nested case-control study
Opstelten, Jorrit L. ; Chan, Simon S.M. ; Hart, Andrew R. ; Schaik, Fiona D.M. Van; Siersema, Peter D. ; Lentjes, Eef G.W.M. ; Khaw, Kay Tee ; Luben, Robert ; Key, Timothy J. ; Boeing, Heiner ; Bergmann, Manuela M. ; Overvad, Kim ; Palli, Domenico ; Masala, Giovanna ; Racine, Antoine ; Carbonnel, Franck ; Boutron-Ruault, Marie Christine ; Tjønneland, Anne ; Olsen, Anja ; Andersen, Vibeke ; Kaaks, Rudolf ; Kuhn, Tilman ; Tumino, Rosario ; Trichopoulou, Antonia ; Peeters, Petra H.M. ; Verschuren, W.M.M. ; Witteman, Ben J.M. ; Oldenburg, Bas - \ 2018
Inflammatory Bowel Diseases 24 (2018)3. - ISSN 1078-0998 - p. 633 - 640.
Crohn's disease - etiology - inflammatory bowel disease - ulcerative colitis - Vitamin D

Background A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age, date of recruitment, and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC. Results Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. Compared with the lowest quartile, no associations with the 3 higher quartiles of vitamin D concentrations were observed for CD (p trend = 0.34) or UC (p trend = 0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend = 0.39) or UC (p trend = 0.83). Conclusions Vitamin D status was not associated with the development of CD or UC. This does not suggest a major role for vitamin D deficiency in the etiology of IBD, although larger studies are needed to confirm these findings.

Correction : Diffusible repression of cytokinin signalling produces endodermal symmetry and passage cells (Nature (2018) DOI: 10.1038/nature25976)
Andersen, Tonni G. ; Naseer, Sadaf ; Ursache, Robertas ; Wybouw, Brecht ; Smet, Wouter ; Rybel, Bert De; Vermeer, Joop E.M. ; Geldner, Niko - \ 2018
Nature 559 (2018)7714. - ISSN 0028-0836 - p. E9 - E9.

In this Letter, owing to a copying error in Illustrator, the two centre panels in Extended Data Fig. 7a were identical. This error has been corrected online. The old, incorrect Extended Data Fig. 7 is shown in the Supplementary Information to this Amendment for transparency. Some typos ('occurence') in Figs. 1, 2 and 3 have also been corrected and the publication details for ref. 32 have been added.

A UAV-based active AirCore system for measurements of greenhouse gases
Andersen, Truls ; Scheeren, Bert ; Peters, Wouter ; Chen, Huilin - \ 2018
Atmospheric Measurement Techniques 11 (2018)5. - ISSN 1867-1381 - p. 2683 - 2699.
We developed and field-tested an unmanned aerial vehicle (UAV)-based active AirCore for atmospheric mole fraction measurements of CO2, CH4, and CO. The system applies an alternative way of using the AirCore technique invented by NOAA. As opposed to the conventional concept of passively sampling air using the atmospheric pressure gradient during descent, the active AirCore collects atmospheric air samples using a pump to pull the air through the tube during flight, which opens up the possibility to spatially sample atmospheric air. The active AirCore system used for this study weighs ∼-1.1-kg. It consists of a ∼-50-m long stainless-steel tube, a small stainless-steel tube filled with magnesium perchlorate, a KNF micropump, and a 45-μm orifice working together to form a critical flow of dried atmospheric air through the active AirCore. A cavity ring-down spectrometer (CRDS) was used to analyze the air samples on site not more than 7-min after landing for mole fraction measurements of CO2, CH4, and CO. We flew the active AirCore system on a UAV near the atmospheric measurement station at Lutjewad, located in the northwest of the city of Groningen in the Netherlands. Five consecutive flights took place over a 5-h period on the same morning, from sunrise until noon. We validated the measurements of CO2 and CH4 from the active AirCore against those from the Lutjewad station at 60-m. The results show a good agreement between the measurements from the active AirCore and the atmospheric station (N-Combining double low line-146; R2CO2: 0.97 and R2CH4: 0.94; and mean differences: CO2: 0.18-ppm and CH4: 5.13-ppb). The vertical and horizontal resolution (for CH4) at typical UAV speeds of 1.5 and 2.5-m-s-1 were determined to be ±24.7 to 29.3 and ±41.2 to 48.9-m, respectively, depending on the storage time. The collapse of the nocturnal boundary layer and the buildup of the mixed layer were clearly observed with three consecutive vertical profile measurements in the early morning hours. Besides this, we furthermore detected a CH4 hotspot in the coastal wetlands from a horizontal flight north to the dike, which demonstrates the potential of this new active AirCore method to measure at locations where other techniques have no practical access.
Diffusible repression of cytokinin signalling produces endodermal symmetry and passage cells
Andersen, Tonni Grube ; Naseer, Sadaf ; Ursache, Robertas ; Wybouw, Brecht ; Smet, Wouter ; Rybel, Bert De; Vermeer, Joop E.M. ; Geldner, Niko - \ 2018
Nature 555 (2018)7697. - ISSN 0028-0836 - p. 529 - 533.
In vascular plants, the root endodermis surrounds the central vasculature as a protective sheath that is analogous to the polarized epithelium in animals, and contains ring-shaped Casparian strips that restrict diffusion. After an initial lag phase, individual endodermal cells suberize in an apparently random fashion to produce 'patchy' suberization that eventually generates a zone of continuous suberin deposition. Casparian strips and suberin lamellae affect paracellular and transcellular transport, respectively. Most angiosperms maintain some isolated cells in an unsuberized state as so-called 'passage cells', which have previously been suggested to enable uptake across an otherwise-impermeable endodermal barrier. Here we demonstrate that these passage cells are late emanations of a meristematic patterning process that reads out the underlying non-radial symmetry of the vasculature. This process is mediated by the non-cell-autonomous repression of cytokinin signalling in the root meristem, and leads to distinct phloem- and xylem-pole-associated endodermal cells. The latter cells can resist abscisic acid-dependent suberization to produce passage cells. Our data further demonstrate that, during meristematic patterning, xylem-pole-associated endodermal cells can dynamically alter passage-cell numbers in response to nutrient status, and that passage cells express transporters and locally affect the expression of transporters in adjacent cortical cells.
The Essential Elements of a Risk Governance Framework for Current and Future Nanotechnologies
Stone, Vicki ; Führ, Martin ; Feindt, Peter H. ; Bouwmeester, Hans ; Linkov, Igor ; Sabella, Stefania ; Murphy, Finbarr ; Bizer, Kilian ; Tran, Lang ; Ågerstrand, Marlene ; Fito, Carlos ; Andersen, Torben ; Anderson, Diana ; Bergamaschi, Enrico ; Cherrie, John W. ; Cowan, Sue ; Dalemcourt, Jean Francois ; Faure, Michael ; Gabbert, Silke ; Gajewicz, Agnieszka ; Fernandes, Teresa F. ; Hristozov, Danail ; Johnston, Helinor J. ; Lansdown, Terry C. ; Linder, Stefan ; Marvin, Hans J.P. ; Mullins, Martin ; Purnhagen, Kai ; Puzyn, Tomasz ; Sanchez Jimenez, Araceli ; Scott-Fordsmand, Janeck J. ; Streftaris, George ; Tongeren, Martie van; Voelcker, Nicolas H. ; Voyiatzis, George ; Yannopoulos, Spyros N. ; Poortvliet, P.M. - \ 2018
Risk Analysis 38 (2018)7. - ISSN 0272-4332 - p. 1321 - 1331.
Decision making - Nano-regulation - Risk communication - Risk governance - Risk management
Societies worldwide are investing considerable resources into the safe development and use of nanomaterials. Although each of these protective efforts is crucial for governing the risks of nanomaterials, they are insufficient in isolation. What is missing is a more integrative governance approach that goes beyond legislation. Development of this approach must be evidence based and involve key stakeholders to ensure acceptance by end users. The challenge is to develop a framework that coordinates the variety of actors involved in nanotechnology and civil society to facilitate consideration of the complex issues that occur in this rapidly evolving research and development area. Here, we propose three sets of essential elements required to generate an effective risk governance framework for nanomaterials. (1) Advanced tools to facilitate risk-based decision making, including an assessment of the needs of users regarding risk assessment, mitigation, and transfer. (2) An integrated model of predicted human behavior and decision making concerning nanomaterial risks. (3) Legal and other (nano-specific and general) regulatory requirements to ensure compliance and to stimulate proactive approaches to safety. The implementation of such an approach should facilitate and motivate good practice for the various stakeholders to allow the safe and sustainable future development of nanotechnology.
Responsible innovation and the circular economy: common themes and missed opportunities
Iñigo, E. ; Blok, V. - \ 2018
In: Governance and Sustainability of Responsible Research and Innovation Processes / Ferri, F., Dwyer, N., Raicevich, S., Grifoni, P., Altiok, H., Andersen, H.T., Laouris, Y., Silvestri, C., Springer (SpringerBriefs in Research and Innovation Governance ) - ISBN 9783319731056
Sustainable Nitrogen Management in Denmark
Dalgaard, Tommy ; Brock, S. ; Graversgaard, Morten ; Hansen, Brigitte ; Hashemi, F. ; Häsler, B. ; Hertel, O. ; Hutchings, N.J. ; Jacobsen, B.H. ; Stoumann Jensen, L. ; Kjeldsen, Chris ; Olesen, J.E. ; Schjorring, J.K. ; Sigsgaard, T. ; Stubkjaer Andersen, P. ; Termansen, Mette ; Vejre, H. ; Vestergaard Odgaard, M. ; Vries, W. de; Wiborg, I.A. - \ 2017
In: Innovative solutions for sustainable management of nitrogen. - Aarhus University and the Research Alliance - ISBN 9788793398825 - p. 13 - 16.
Innovative solutions for sustainable management of nitrogen : Conference proceedings
Dalgaard, Tommy ; Olesen, J.E. ; Schjorring, J.K. ; Jensen, J.S. ; Vejre, H. ; Andersen, P.S. ; Gundersen, P. ; Jacobsen, B.H. ; Jensen, J. ; Häsler, B. ; Termansen, Mette ; Hertel, O. ; Brock, S. ; Kronvang, B. ; Svenning, Jens Christian ; Sigsgaard, T. ; Hansen, B. ; Thorling, L. ; Højberg, A.L. ; Wiborg, I.A. ; Piil, K. ; Kjeldsen, Chris ; Graversgaard, Morten ; Hutchings, N. ; Vries, W. de; Christensen, J. ; Mukendi, T. - \ 2017
Aarhus University and the Research Alliance - ISBN 9788793398825 - 142 p.
Experiences from a wearable-mobile acquisition system for ambulatory assessment of diet and activity
Laerhoven, Kristof Van; Wenzel, Mario ; Geelen, Anouk ; Hübel, Christopher ; Wolters, Maike ; Hebestreit, Antje ; Andersen, Lene Frost ; Veer, Pieter van 't; Kubiak, Thomas - \ 2017
In: Proceedings of the 4th international Workshop on Sensor-Based Activity Recognition and Interaction. - Association for Computing Machinery - ISBN 9781450352239
Activity recognition - Barcode scanning - Beverage consumption logging - Multi-modal data collection - Presentation

Public health trends are currently monitored and diagnosed based on large studies that often rely on pen-and-paper data methods that tend to require a large collection campaign. With the pervasiveness of smart-phones and -watches throughout the general population, we argue in this paper that such devices and their built-in sensors can be used to capture such data more accurately with less of an effort. We present a system that targets a pan-European and harmonised architecture, using smartphones and wrist-worn activity loggers to enable the collection of data to estimate sedentary behavior and physical activity, plus the consumption of sugar-sweetened beverages. We report on a unified pilot study across three countries and four cities (with different languages, locale formats, and data security and privacy laws) in which 83 volunteers were asked to log beverages consumption along with a series of surveys and longitudinal accelerometer data. Our system is evaluated in terms of compliance, obtained data, and first analyses.

Innovation systems for transformations towards sustainability? Taking the normative dimension seriously
Schlaile, Michael P. ; Urmetzer, Sophie ; Blok, Vincent ; Andersen, Allan Dahl ; Timmermans, Job ; Mueller, Matthias ; Fagerberg, Jan ; Pyka, Andreas - \ 2017
Sustainability 9 (2017)12. - ISSN 2071-1050
Dedicated innovation systems - Directionality - Innovation systems - Legitimacy - Normativity - Paradigms - Responsibility - Transformations towards sustainability - Wicked problems
The aim of this article is to complement research on transformations towards sustainability by drawing upon the innovation systems (IS) framework. The IS framework already serves as a suitable and influential basis for research on processes of technological innovation and economic change. We argue that improving the capacity of an IS framework for dealing with wicked problems and the normative complexity of sustainability requires a fundamental paradigm shift because in the current IS paradigm innovations are considered as per se desirable and in mostly technological terms. Therefore, we call for IS dedicated to transformations towards sustainability by opening up for systemic innovations beyond the technological dimension and by acknowledging that stakeholders have conflicting visions, interests, norms, and expectations with regard to sustainability goals. Taking the normative dimension of transformations towards sustainability seriously thus requires more explicit and integrative research on directionality, legitimacy, responsibility, and their interrelation in IS. The article concludes by proposing suggestions for future research based on IS-related approaches that can serve as building blocks for an IS framework capable of incorporating legitimate goal-orientation for transformative innovation by and for society.
Tea and coffee consumption in relation to DNA methylation in four European cohorts
Ek, Weronica E. ; Tobi, Elmar W. ; Ahsan, Muhammad ; Lampa, Erik ; Ponzi, Erica ; Kyrtopoulos, Soterios A. ; Georgiadis, Panagiotis ; Lumey, L.H. ; Heijmans, Bastiaan T. ; Botsivali, Maria ; Bergdahl, Ingvar A. ; Karlsson, Torgny ; Rask-Andersen, Mathias ; Palli, Domenico ; Ingelsson, Erik ; Hedman, Åsa K. ; Nilsson, Lena Maria ; Vineis, Paolo ; Lind, Lars ; Flanagan, James M. ; Johansson, Åsa - \ 2017
Human Molecular Genetics 26 (2017)16. - ISSN 0964-6906 - p. 3221 - 3231.

Lifestyle factors, such as food choices and exposure to chemicals, can alter DNAmethylation and lead to changes in gene activity. Two such exposures with pharmacologically active components are coffee and tea consumption. Both coffee and tea have been suggested to play an important role inmodulating disease-risk in humans by suppressing tumour progression, decreasing inflammation and influencing estrogenmetabolism. Thesemechanismsmay bemediated by changes in DNA methylation. To investigate if DNAmethylation in blood is associated with coffee and tea consumption, we performed a genome-wide DNAmethylation study for coffee and tea consumption in four European cohorts (N=3,096). DNAmethylation wasmeasured fromwhole blood at 421,695 CpG sites distributed throughout the genome and analysed inmen and women both separately and together in each cohort. Meta-analyses of the results and additional regional-level analyses were performed. After adjusting formultiple testing, themeta-analysis revealed that two individual CpG-sites,mapping to DNAJC16 and TTC17, were differentiallymethylated in relation to tea consumption in women. No individual sites were associated withmen or with the sex-combined analysis for tea or coffee. The regional analysis revealed that 28 regions were differentiallymethylated in relation to tea consumption in women. These regions contained genes known to interact with estradiolmetabolismand cancer. No significant regions were found in the sex-combined andmale-only analysis for either tea or coffee consumption.

Accounting for carbon stocks in soils and measuring GHGs emission fluxes from soils : Do we have the necessary standards?
Bispo, Antonio ; Andersen, Lizzi ; Angers, Denis A. ; Bernoux, Martial ; Brossard, Michel ; Cécillon, Lauric ; Comans, Rob N.J. ; Harmsen, Joop ; Jonassen, Knut ; Lamé, Frank ; Lhuillery, Caroline ; Maly, Stanislav ; Martin, Edith ; Mcelnea, Angus E. ; Sakai, Hiro ; Watabe, Yoichi ; Eglin, Thomas K. - \ 2017
Frontiers in Environmental Science 5 (2017)JUL. - ISSN 2296-665X
Carbon sequestration - Methane - Nitrous oxide - Soil - Standards
Soil is a key compartment for climate regulation as a source of greenhouse gases (GHGs) emissions and as a sink of carbon. Thus, soil carbon sequestration strategies should be considered alongside reduction strategies for other greenhouse gas emissions. Taking this into account, several international and European policies on climate change are now acknowledging the importance of soils, which means that proper, comparable and reliable information is needed to report on carbon stocks and GHGs emissions from soil. It also implies a need for consensus on the adoption and verification of mitigation options that soil can provide. Where consensus is a key aspect, formal standards and guidelines come into play. This paper describes the existing ISO soil quality standards that can be used in this context, and calls for new ones to be developed through (international) collaboration. Available standards cover the relevant basic soil parameters including carbon and nitrogen content but do not yet consider the dynamics of those elements. Such methods have to be developed together with guidelines consistent with the scale to be investigated and the specific use of the collected data. We argue that this standardization strategy will improve the reliability of the reporting procedures and results of the different climate models that rely on soil quality data.
Safety evaluation of a novel muramidase for feed application
Lichtenberg, J. ; Perez Calvo, E. ; Madsen, K. ; Østergaard Lund, T. ; Kramer Birkved, F. ; Cauwenberghe, S. van; Mourier, M. ; Wulf-Andersen, L. ; Jansman, A.J.M. ; Lopez-Ulibarri, R. - \ 2017
Regulatory Toxicology and Pharmacology 89 (2017). - ISSN 0273-2300 - p. 57 - 69.
Chickens - Feed - Feed additive - Lysozyme - Muramidase - Safety - Toxicology - Trichoderma reesei
Safety evaluation of a muramidase produced by a Trichoderma reesei strain (safe lineage), expressing a muramidase gene isolated from Acremonium alcalophilum is presented. Intended use in feed of this enzyme is as digestive aid in broiler chickens. Muramidase 007, was non-mutagenic and non-clastogenic in vitro, and no adverse effects were observed in 90-day subchronic toxicity studies in rats at doses up to 1132 mg TOS/kg body weight/day. The enzyme did not exhibit, in vitro, skin, nor eye irritation potential. Acute aquatic toxicity evaluated on daphnia and algae showed absence of effect of the enzyme at the standard doses tested. Muramidase 007 was fully tolerated by broiler chickens in a 6-weeks tolerance study showing no adverse effects in any of the dietary treatments (0, 1×, 5× and 10× maximum recommended dose). In conclusion, Muramidase 007 is found to be toxicologically inert, and there are no worker's safety concerns if standard precautions are instituted and a non-dusty formulation is employed. Muramidase 007 is well tolerated by the target species (broiler chickens) and cause no harm to the environment. The beneficial safety evaluation of Muramidase 007 is in line with this type of enzyme that is found ubiquitously in nature.
Microarray profiling of gene expression in Alpha-Synuclein aggregations and its alteration by natural genetic variation in Caenorhabditis elegans
Wang, Yiru ; Snoek, L.B. ; Sterken, M.G. ; Riksen, J.A.G. ; Cook, D. ; Tanny, R.E. ; Andersen, E.C. ; Kammenga, J.E. ; Harvey, S. - \ 2017
Neurodegenerative diseases (NGDs), such as Alzheimer’s diseases (AD) and Parkinson’s diseases (PD), are characterized by progressive degeneration in the human nervous system. The nematode C. elegans is an excellent model in which to study NGDs due to the high level of conservation of gene functions compared to humans. However, C. elegans research largely relies on a single worm genotype – the canonical N2 strain – limiting the ability to explore how naturally varying alleles alter pathological mechanisms in NGDs. In order to identify how genetic variation acts on NGDs, we analyzed transgenic animals that express aggregating human proteins associated with molecular pathogenic progression of NGDs in five genetic backgrounds.

Here, starting with the original transgenic strain expressing the human synaptic protein alpha-synuclein in an N2 genetic background, we have introgressed the PD transgene (unc-54:: α-Syn:: YFP) into four different wild type genetic backgrounds. Analysis of these new transgenic introgressed lines indicates that transgene effects vary greatly depending on the genetic background. To understand the genetic bases of these phenotypic differences, we have sequenced these new lines to recognize confounder of the heterogeneity in transgenes, measured various aspects of the life history, and investigated gene expression differences by microarray. These analyses identified genes that are up- and down-regulated in all genotypes and genes that expressed at a specific stage to particular genetic backgrounds. For example, the differential developments of those lines have been also confirmed from microarray data that the gene vit-1 expressed at different levels between the lines. Functional enrichment links these genes to the aggregation of alpha-synuclein, which is causative of PD, to the associated developmental arrest, metabolic, and cellular repair mechanisms.

Our studies provide opportunities to observe alterations in traits, including global gene expression, associated with the toxicity of misfolded protein aggregation that could not be readily observed in the canonical N2 background. This is a necessary and important step to identify the alleles responsible for individual variation in the onset and progression of NGDs.

Denial of long-term issues with agriculture on tropical peatlands will have devastating consequences
Wijedasa, Lahiru S. ; Jauhiainen, Jyrki ; Könönen, Mari ; Lampela, Maija ; Vasander, Harri ; Leblanc, Marie-Claire ; Evers, Stephanie ; Smith, Thomas E.L. ; Yule, Catherine M. ; Varkkey, Helena ; Lupascu, Massimo ; Parish, Faizal ; Singleton, Ian ; Clements, Gopalasamy R. ; Aziz, Sheema Abdul ; Harrison, Mark E. ; Cheyne, Susan ; Anshari, Gusti Z. ; Meijaard, Erik ; Goldstein, Jenny E. ; Waldron, Susan ; Hergoualc'h, Kristell ; Dommain, Rene ; Frolking, Steve ; Evans, Christopher D. ; Posa, Mary Rose C. ; Glaser, Paul H. ; Suryadiputra, Nyoman ; Lubis, Reza ; Santika, Truly ; Padfield, Rory ; Kurnianto, Sofyan ; Hadisiswoyo, Panut ; Lim, Teck Wyn ; Page, Susan E. ; Gauci, Vincent ; Meer, Peter J. Van Der; Buckland, Helen ; Garnier, Fabien ; Samuel, Marshall K. ; Choo, Liza Nuriati Lim Kim ; O'reilly, Patrick ; Warren, Matthew ; Suksuwan, Surin ; Sumarga, Elham ; Jain, Anuj ; Laurance, William F. ; Couwenberg, John ; Joosten, Hans ; Vernimmen, Ronald ; Hooijer, Aljosja ; Malins, Chris ; Cochrane, Mark A. ; Perumal, Balu ; Siegert, Florian ; Peh, Kelvin S.H. ; Comeau, Louis-Pierre ; Verchot, Louis ; Harvey, Charles F. ; Cobb, Alex ; Jaafar, Zeehan ; Wösten, Henk ; Manuri, Solichin ; Müller, Moritz ; Giesen, Wim ; Phelps, Jacob ; Yong, Ding Li ; Silvius, Marcel ; Wedeux, Béatrice M.M. ; Hoyt, Alison ; Osaki, Mitsuru ; Hirano, Takashi ; Takahashi, Hidenori ; Kohyama, Takashi S. ; Haraguchi, Akira ; Nugroho, Nunung P. ; Coomes, David A. ; Quoi, Le Phat ; Dohong, Alue ; Gunawan, Haris ; Gaveau, David L.A. ; Langner, Andreas ; Lim, Felix K.S. ; Edwards, David P. ; Giam, Xingli ; Werf, Guido Van Der; Carmenta, Rachel ; Verwer, Caspar C. ; Gibson, Luke ; Gandois, Laure ; Graham, Laura Linda Bozena ; Regalino, Jhanson ; Wich, Serge A. ; Rieley, Jack ; Kettridge, Nicholas ; Brown, Chloe ; Pirard, Romain ; Moore, Sam ; Capilla, B.R. ; Ballhorn, Uwe ; Ho, Hua Chew ; Hoscilo, Agata ; Lohberger, Sandra ; Evans, Theodore A. ; Yulianti, Nina ; Blackham, Grace ; Onrizal, O. ; Husson, Simon ; Murdiyarso, Daniel ; Pangala, Sunita ; Cole, Lydia E.S. ; Tacconi, Luca ; Segah, Hendrik ; Tonoto, Prayoto ; Lee, Janice S.H. ; Schmilewski, Gerald ; Wulffraat, Stephan ; Putra, Erianto Indra ; Cattau, Megan E. ; Clymo, R.S. ; Morrison, Ross ; Mujahid, Aazani ; Miettinen, Jukka ; Liew, Soo Chin ; Valpola, Samu ; Wilson, David ; Arcy, Laura D'; Gerding, Michiel ; Sundari, Siti ; Thornton, Sara A. ; Kalisz, Barbara ; Chapman, Stephen J. ; Su, Ahmad Suhaizi Mat ; Basuki, Imam ; Itoh, Masayuki ; Traeholt, Carl ; Sloan, Sean ; Sayok, Alexander K. ; Andersen, Roxane - \ 2017
Global Change Biology 23 (2017)3. - ISSN 1354-1013 - p. 977 - 982.
The first International Peat Congress (IPC) held in the tropics – in Kuching (Malaysia) – brought together over 1000 international peatland scientists and industrial partners from across the world (“International Peat Congress with over 1000 participants!,” 2016). The congress covered all aspects of peatland ecosystems and their management, with a strong focus on the environmental, societal and economic challenges associated with contemporary large-scale agricultural conversion of tropical peat.
A systematic review of methods to assess intake of sugar-sweetened beverages among healthy European adults and children : a DEDIPAC (DEterminants of DIet and Physical Activity) study
Riordan, Fiona ; Ryan, Kathleen ; Perry, Ivan J. ; Schulze, Matthias B. ; Andersen, Lene Frost ; Geelen, Anouk ; Veer, Pieter van 't; Eussen, Simone ; Dongen, Martien van; Wijckmans-Duysens, Nicole ; Harrington, Janas M. - \ 2017
Public Health Nutrition 20 (2017)4. - ISSN 1368-9800 - p. 578 - 597.
Research indicates that intake of sugar-sweetened beverages (SSB) may be associated with negative health consequences. However, differences between assessment methods can affect the comparability of intake data across studies. The current review aimed to identify methods used to assess SSB intake among children and adults in pan-European studies and to inform the development of the DEDIPAC (DEterminants of DIet and Physical Activity) toolbox of methods suitable for use in future European studies.

A literature search was conducted using three electronic databases and by hand-searching reference lists. English-language studies of any design which assessed SSB consumption were included in the review.

Studies involving two or more European countries were included in the review.

Healthy, free-living children and adults.

The review identified twenty-three pan-European studies which assessed intake of SSB. The FFQ was the most commonly used (n 24), followed by the 24 h recall (n 6) and diet records (n 1). There were several differences between the identified FFQ, including the definition of SSB used. In total, seven instruments that were tested for validity were selected as potentially suitable to assess SSB intake among adults (n 1), adolescents (n 3) and children (n 3).

The current review highlights the need for instruments to use an agreed definition of SSB. Methods that were tested for validity and used in pan-European populations encompassing a range of countries were identified. These methods should be considered for use by future studies focused on evaluating consumption of SSB.
A systematic review of methods to assess intake of fruits and vegetables among healthy European adults and children : a DEDIPAC (DEterminants of DIet and Physical Activity) study
Riordan, Fiona ; Ryan, Kathleen ; Perry, Ivan J. ; Schulze, Matthias B. ; Andersen, Lene Frost ; Geelen, Anouk ; van’t Veer, Pieter ; Eussen, Simone ; Dagnelie, Pieter ; Wijckmans-Duysens, Nicole ; Harrington, Janas M. - \ 2017
Public Health Nutrition 20 (2017)3. - ISSN 1368-9800 - p. 417 - 448.
DEDIPAC - Dietary assessment - Europe - Fruits and vegetables

Objective: Evidence suggests that health benefits are associated with consuming recommended amounts of fruits and vegetables (F&V), yet standardised assessment methods to measure F&V intake are lacking. The current review aims to identify methods to assess F&V intake among children and adults in pan-European studies and inform the development of the DEDIPAC (DEterminants of DIet and Physical Activity) toolbox of methods suitable for use in future European studies. Design: A literature search was conducted using three electronic databases and by hand-searching reference lists. English-language studies of any design which assessed F&V intake were included in the review. Setting: Studies involving two or more European countries were included in the review. Subjects: Healthy, free-living children or adults. Results: The review identified fifty-one pan-European studies which assessed F&V intake. The FFQ was the most commonly used (n 42), followed by 24 h recall (n 11) and diet records/diet history (n 7). Differences existed between the identified methods; for example, the number of F&V items on the FFQ and whether potatoes/legumes were classified as vegetables. In total, eight validated instruments were identified which assessed F&V intake among adults, adolescents or children. Conclusions: The current review indicates that an agreed classification of F&V is needed in order to standardise intake data more effectively between European countries. Validated methods used in pan-European populations encompassing a range of European regions were identified. These methods should be considered for use by future studies focused on evaluating intake of F&V.

Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus
Larsen, Jesper ; Stegger, Marc ; Andersen, Paal S. ; Wagenaar, Jaap A. - \ 2016
Clinical infectious diseases 63 (2016)10. - ISSN 1058-4838 - p. 1349 - 1352.
foodborne transmission - host adaptation - livestock - MRSA - poultry
We investigated the evolution and epidemiology of a novel livestock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes and infects urban-dwelling Danes even without a Danish animal reservoir. Genetic evidence suggests both poultry and human adaptation, with poultry meat implicated as a probable source.
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