Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Nationwide screening of surface water toxicity to algae
Baat, M.L. de; Bas, D.A. ; Beusekom, S.A.M. van; Droge, S.T.J. ; Meer, F. van der; Vries, M. de; Verdonschot, P.F.M. ; Kraak, M.H.S. - \ 2018
Science of the Total Environment 645 (2018). - ISSN 0048-9697 - p. 780 - 787.
Algal toxicity - Herbicide risk - Nationwide screening - Pulse amplitude modulation fluorometry - Surface water

According to the European Water Framework Directive (WFD), chemical water quality is assessed by monitoring 45 priority substances. However, observed toxic effects can often not be attributed to these priority substances, and therefore there is an urgent need for an effect-based monitoring strategy that employs bioassays to identify environmental risk. Algal photosynthesis is a sensitive process that can be applied to identify the presence of hazardous herbicides in surface water. Therefore, the aim of this study was to employ an algal photosynthesis bioassay to assess surface water toxicity to algae and to identify the compounds causing the observed effects. To this purpose, Raphidocelis subcapitata was exposed to surface water samples and after 4.5 h photosynthetic efficiency was determined using PAM fluorometry. In this rapid high throughput bioassay, algal photosynthesis was affected by surface water from only one of 39 locations. Single compounds toxicity confirmation elucidated that the observed effect could be solely attributed to the herbicide linuron, which occurred at 110 times the EQS concentration and which is not included in the WFD priority substances list. In conclusion, applying the algal photosynthesis bioassay enables more efficient and effective assessment of toxicity to primary producers because it: (i) identifies the presence of herbicides that would be overlooked by routine chemical WFD monitoring, and (ii) avoids redundant chemical analyses by focusing only on (non-)target screening in samples with demonstrated effects.

Effect of Obesity or Metabolic Syndrome and Diabetes on Osseointegration of Dental Implants in a Miniature Swine Model : A Pilot Study
Coelho, Paulo G. ; Pippenger, Benjamin ; Tovar, Nick ; Koopmans, Sietse Jan ; Plana, Natalie M. ; Graves, Dana T. ; Engebretson, Steve ; Beusekom, Heleen M.M. van; Oliveira, Paula G.F.P. ; Dard, Michel - \ 2018
Journal of Oral and Maxillofacial Surgery 76 (2018)8. - ISSN 0278-2391 - p. 1677 - 1687.
Purpose: The increasing prevalence of obesity or metabolic syndrome (O/MS) and type 2 diabetes mellitus (DM) remains a global health concern. Clinically relevant and practical translational models mimicking human characteristics of these conditions are lacking. This study aimed to demonstrate proof of concept of the induction of stable O/MS and type 2 DM in a Göttingen minipig model and validate both of these disease-adjusted Göttingen minipig models as impaired healing models for the testing of dental implants. Materials and Methods: Nine minipigs were split into 3 groups—control (normal diet), obese (cafeteria diet), and diabetic (cafeteria diet plus low-dosage streptozotocin)—followed by placement of dental implants. Inflammatory markers including tumor necrosis factor α, C-reactive protein, and cortisol were recorded for each study group. Removal torque was measured, and histomorphometric analysis (bone-to-implant contact and bone area fraction occupancy) was performed. Results: O/MS pigs showed, on average, a 2-fold increase in plasma C-reactive protein (P <.05) and cortisol (P <.09) concentrations compared with controls; DM pigs showed, on average approximately, a 40-fold increase in plasma tumor necrosis factor α levels (P <.05) and a 2-fold increase in cortisol concentrations (P <.05) compared with controls. The impact of O/MS and DM on implants was determined. The torque to interface failure was highest in the control group (200 N-cm) and significantly lower in the O/MS (90 N-cm) and DM (60 N-cm) groups (P <.01). Bone formation around implants was significantly greater in the control group than in the O/MS and DM groups (P <.02). Conclusions: Both O/MS and DM minipigs express a human-like disease phenotype, and both presented bone-healing impairment around dental implants. Our finding of no significant difference between type 2 DM and O/MS in bone formation around implants provides evidence that further investigation of the impact of O/MS is warranted.
Herwaardering van een vergeten bodemverbeteraar : steenmeel voor bodemvruchtbaarheid en klimaatdoelstellingen landbouw
Rietra, R.P.J.J. ; Beusekom, M. van; Bergsma, H. - \ 2012
Bodem 22 (2012)4. - ISSN 0925-1650 - p. 34 - 36.
bodemvruchtbaarheid - bodemverbeteraars - grondverbeteraars - mulches - duurzaamheid (sustainability) - soil fertility - soil conditioners - soil amendments - sustainability
Nieuwe ideeën brengen mensen op de been. Vanuit verschillende invalshoeken zijn we bezig steenmelen toe te passen op bodems: om bodems vruchtbaarder te maken, om klimaatdoelstellingen van de agrarische sector te behalen, en om ontwikkelingslanden meer mogelijkheden te geven om eigen grondstoffen te gebruiken. De zoektocht naar geschikte steenmelen vraagt inbreng van verschillende partijen.
Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetes
Heuvel, M. van den; Sorop, O. ; Koopmans, S.J. ; Dekker, R.A. ; Vries, R. de; Beusekom, H.M.M. ; Eringa, E.C. ; Duncker, D.J. ; Danser, A.H.J. ; Giessen, W.J. - \ 2012
American Journal of Physiology : Heart and Circulatory Physiology 302 (2012)1. - ISSN 0363-6135 - p. H85 - H95.
prediabetic metabolic syndrome - arterial resistance vessels - endothelial dysfunction - insulin-resistance - contractile responses - glucose-tolerance - s-nitrosothiols - risk-factors - blood-flow - mellitus
Detailed evaluation of coronary function early in diabetes mellitus (DM)-associated coronary artery disease (CAD) development is difficult in patients. Therefore, we investigated coronary conduit and small artery function in a preatherosclerotic DM porcine model with type 2 characteristics. Streptozotocin-induced DM pigs on a saturated fat/cholesterol (SFC) diet (SFC + DM) were compared with control pigs on SFC and standard (control) diets. SFC + DM pigs showed DM-associated metabolic alterations and early atherosclerosis development in the aorta. Endothelium-dependent vasodilation to bradykinin (BK), with or without blockade of nitric oxide (NO) synthase, endothelium-independent vasodilation to an exogenous NO-donor (S-nitroso-N-acetylpenicillamine), and vasoconstriction to endothelin (ET)-1 with blockade of receptor subtypes, were assessed in vitro. Small coronary arteries, but not conduit vessels, showed functional alterations including impaired BK-induced vasodilatation due to loss of NO (P <0.01 vs. SFC and control) and reduced vasoconstriction to ET-1 (P <0.01 vs. SFC and control), due to a decreased ETA receptor dominance. Other vasomotor responses were unaltered. In conclusion, this model demonstrates specific coronary microvascular alterations with regard to NO and ET-1 systems in the process of early atherosclerosis in DM. In particular, the altered ET-1 system correlated with hyperglycemia in atherogenic conditions, emphasizing the importance of this system in DM-associated CAD development.
Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs
Koopmans, S.J. ; Dekker, R.A. ; Ackermans, M.T. ; Sauerwein, H.P. ; Serlie, M.J. ; Beusekom, H.M.M. ; Heuvel, M. van den; Giessen, W.J. - \ 2011
Cardiovascular Diabetology 10 (2011). - ISSN 1475-2840 - 11 p.
cardiovascular-disease - insulin-resistance - coronary-arteries - carbohydrate - inflammation - interleukin-6 - nutrigenomics - hyperglycemia - proliferator - nutrition
Background Diabetes is thought to accelerate cardiovascular disease depending on the type of diet. This study in diabetic subjects was performed to investigate the metabolic, inflammatory and cardiovascular effects of nutritional components typically present in a Western, Mediterranean or high glycaemic diet. Methods Streptozotocin-diabetic pigs (~45 kg) were fed for 10 weeks supplemental (40% of dietary energy) saturated fat/cholesterol (SFC), unsaturated fat (UF) or starch (S) in an eucaloric dietary intervention study. Results Fasting plasma total, LDL and HDL cholesterol concentrations were 3-5 fold higher (p <0.01) in SFC compared to UF and S pigs. Fasting plasma NEFA concentrations (mmol/L) were highest (p <0.05) in SFC (1.09 ± 0.17), intermediate in UF (0.80 ± 0.14) and lowest in S pigs (0.58 ± 0.14) whereas plasma glucose (~13 mmol/L), triglyceride (~0.5 mmol/L) and insulin (~24 pmol/L) concentrations were comparable among SFC, UF and S pigs. The postprandial response area under the curves (AUC, 0-4 h) for glucose but not for insulin and triglyceride responses were intermediate in SFC (617 ± 144) and lowest (p <0.05) in UF (378 ± 157) compared to S pigs (925 ± 139). Fasting hepatic glucose production, hepatic and peripheral insulin sensitivity and blood pressure were not different among pigs. C-reactive protein (CRP) concentrations (mg/L) were highest (p <0.05) in SFC (25 ± 4), intermediate in S (21 ± 3) and lowest in UF pigs (14 ± 2). Liver weights, liver and muscle triglyceride concentrations, and the surface area of aorta fatty streaks were highest (p <0.01) in SFC pigs. A positive correlation between postprandial plasma CRP and aorta fatty streaks was observed in SFC pigs (R2 = 0.95). Retroperitoneal fat depot weight (g) was intermediate in SFC (260 ± 72), lowest in S (135 ± 51) and highest (p <0.05) in UF (571 ± 95) pigs. Conclusion Dietary saturated fat/cholesterol induces inflammation, atherosclerosis and ectopic fat deposition whereas an equally high dietary unsaturated fat load does not induce these abnormalities and shows beneficial effects on postprandial glycaemia in diabetic pigs. Keywords: Diabetes; Insulin; Diet; Unsaturated fat; Saturated fat; Cholesterol; Inflammation; C-reactive protein; Atherosclerosis; Pigs
Roerdomp Elly in Marokkaans suikerriet
Beusekom, R. van - \ 2011
Wageningen : Nature Today
Winterse zwartkop op de sierappeltjes
Beusekom, R. van - \ 2011
Wageningen : Nature Today
Grote stap voorwaarts in internationale bescherming trekvogels
Beusekom, R. van - \ 2011
Wageningen : Nature Today
Storm brengt grote aantallen drieteenmeeuwen voor de kust
Beusekom, R. van - \ 2011
Wageningen : Nature Today
Zangvogel uit de bergen overwintert in zompig Nederland
Beusekom, R. van - \ 2011
Wageningen : Nature Today
Zachte herfst zorgt voor veel activiteit in de natuur
Creemers, R. ; Beusekom, R. van; Veling, K. ; Diek, H. van; Boomsluiter, M. ; Mulder, S. ; Vliet, A.J.H. van; Bron, W.A. ; Slikke, W. van der - \ 2011
Wageningen : Nature Today
Specific coronary drug-eluting stents interfere with distal microvascular function after single stent implantation in pigs.
Heuvel, M. van den; Sorop, O. ; Batenburg, W.W. ; Bakker, C.L. ; Vries, R. de; Koopmans, S.J. ; Beusekom, H.M.M. ; Duncker, D.J. ; Danser, A.H.J. ; Giessen, W.J. - \ 2010
JACC: cardiovascular interventions 3 (2010)7. - ISSN 1936-8798 - p. 723 - 730.
arteries in-vivo - endothelial dysfunction - hyperpolarizing factors - hydrogen-peroxide - s-nitrosothiols - sirolimus - paclitaxel - bradykinin - inhibition - dilation
Objectives The aim of this study was to compare the effects of single drug-eluting stents (DES) on porcine coronary function distal to the stent in vivo and in vitro. Background The mechanism of endothelial dysfunction occurring in human coronary conduit arteries up to 9 months after DES implantation is unknown. Methods A sirolimus-eluting stent (SES), paclitaxel-eluting stent (PES), and a bare-metal stent (BMS) were implanted in the 3 coronary arteries of 11 pigs. After 5 weeks, in vivo responses in distal coronary flow to different doses of bradykinin (BK) and nitrates were measured. In vitro, vasodilation to BK and nitrates, as well as vasoconstriction to endothelin (ET)-1 were assessed in both distal coronary conduit and small arteries. In addition, contributions of nitric oxide (NO) and endothelium-derived hyperpolarizing factors (EDHFs) and cyclic guanosine monophosphate (cGMP) responses to BK-stimulation were determined in vitro. Results Both DES did not alter in vivo distal vasomotion. In vitro distal conduit and small arterial responses to BK were also unaltered; DES did not alter the BK-induced increase in cGMP. However, after NO synthase blockade, PES showed a reduced BK-response in distal small arteries as compared with BMS and SES (p <0.05). The ET-1–induced vasoconstriction and vascular smooth muscle cell function were unaltered. Conclusions In this study of single stenting in healthy porcine coronaries for 5 weeks, SES did not affect distal coronary vascular function, whereas PES altered distal endothelial function of small arteries under conditions of reduced NO bioavailability. Therefore, specifically the EDH-component of microvascular function seems affected by PES.
Aspects of the metabolic syndrome in domestic pigs, fed a high saturated-fat, fructose and cholesterol diet.
Koopmans, S.J. ; Dekker, R.A. ; Meulen, J. van der; Schuurman, T. ; Heuvel, M. van den; Beusekom, H. van; Benthem, B. - \ 2009
Journal of diabetes 1 (2009)Suppl. 1. - ISSN 1753-0393 - p. A238 - A238.
Steeds minder doortrekkende zwarte sterns
Beusekom, R. van - \ 2009
Nature Today 2009 (2009)02-09.
Bosrietzangers gevoelig voor maaien
Beusekom, R. van - \ 2009
Nature Today 2009 (2009)08-07.
Overleeft de roerdomp deze winter?
Beusekom, R. van - \ 2009
Nature Today 2009 (2009)15-01.
Rapportage werkgroep Instrumentarium in het kader van het project Modernisering van de Monumentenzorg (MoMo)
Baalman, D. ; Beusekom, J.W. van; Broeke, I. ; Kistenkas, F.H. ; Rutters, M. ; Stafleu, M. ; Vehof, F. ; Voorhoeve, V. ; Broekhoven, S. - \ 2008
Den Haag : Werkgroep Instrumentarium - 27 p.
Falende grazers : hooglanders als metaforen voor goedkope wildernis
Zeilmaker, R. ; Bokdam, J. - \ 2007
NRC Handelsblad 2007 (2007)24/25 maart. - ISSN 0002-5259 - p. 49 - 49.
schotse hooglander - begrazing - natuurbescherming - grote grazers - highland - grazing - nature conservation - large herbivores
Grote grazers hebben in korte tijd het Nederlandse natuurterrein veroverd. Maar de oerkoeien lijken de vergrassing en verbossing niet te kunnen stoppen. Ondertussen brengen ze schade toe aan fauna en broedvogels. 'Het zijn goedkope grasmaaiers geworden'. Visie van mensen als: Frits van Beusekom, Frans Vera, Peter de Boer. Het was de Wageninger Harm van de Veen, die aan de wieg stond van natuurlijk bosbeheer
Sulfide oxidation at halo-alkaline conditions in a fed-batch bioreactor
Bosch, P.L.F. van den; Beusekom, O.C. van; Buisman, C.J.N. ; Janssen, A.J.H. - \ 2007
Biotechnology and Bioengineering 97 (2007)5. - ISSN 0006-3592 - p. 1053 - 1063.
biologically produced sulfur - aqueous sodium polysulfide - oxidizing bacteria - equilibrium distribution - chemical oxidation - soda lakes - kinetics - reduction - hydrogen - removal
A biotechnological process is described to remove hydrogen sulfide (H2S) from high-pressure natural gas and sour gases produced in the petrochemical industry. The process operates at halo-alkaline conditions and combines an aerobic sulfide-oxidizing reactor with an anaerobic sulfate (SO) and thiosulfate (S2O) reducing reactor. The feasibility of biological H2S oxidation at pH around 10 and total sodium concentration of 2 mol L-1 was studied in gas-lift bioreactors, using halo-alkaliphilic sulfur-oxidizing bacteria (HA-SOB). Reactor operation at different oxygen to sulfide (O2:H2S) supply ratios resulted in a stable low redox potential that was directly related with the polysulfide (S) and total sulfide concentration in the bioreactor. Selectivity for SO formation decreased with increasing S and total sulfide concentrations. At total sulfide concentrations above 0.25 mmol L-1, selectivity for SO formation approached zero and the end products of H2S oxidation were elemental sulfur (S0) and S2O. Maximum selectivity for S0 formation (83.3±0.7%) during stable reactor operation was obtained at a molar O2:H2S supply ratio of 0.65. Under these conditions, intermediary S plays a major role in the process. Instead of dissolved sulfide (HS-), S seemed to be the most important electron donor for HA-SOB under S0 producing conditions. In addition, abiotic oxidation of S was the main cause of undesirable formation of S2O. The observed biomass growth yield under SO producing conditions was 0.86 g N mol-1 H2S. When selectivity for SO formation was below 5%, almost no biomass growth was observed
Dynamic modelling of food chain accumulation of brominated flame-retardants in fish from the Ebro river basin, Spain
Beusekom, O. van; Eljarrat, E. ; Barcelo, D. ; Koelmans, A.A. - \ 2006
Environmental Toxicology and Chemistry 25 (2006)10. - ISSN 0730-7268 - p. 2553 - 2560.
polybrominated diphenyl ethers - carp cyprinus-carpio - polycyclic aromatic-hydrocarbons - black carbon - polychlorinated-biphenyls - organic-chemicals - decabromodiphenyl ether - temporal trends - lake-ontario - cinca river
Since the 1980s, brominated flame retardants (BFRs) have been detected in air, sewage sludge, sediment, fish, shellfish, birds, and mammals, including humans. However, model studies regarding BFR food-chain accumulation are scarce. In the present study, the accumulation of hexabromocyclododecane and brominated diphenyl ethers (BDEs) 47, 153, 154, and 183 in benthivorous barbel (Barbus graellsii) and pelagic bleak (Alburnus alburnus) from four locations in the Ebro river basin in Spain was modeled using a first-order, one-compartment model with sediment interaction. The model accounted for BFR uptake from water, ingested sediment, and food; release via water and feces; growth; and in situ binding of BFRs to black carbon. Rate constants were derived from allometric regressions. For most BFRs, dynamically modeled biota¿sediment accumulation factors (BSAFs) were close to measured values, whereas steady-state model BSAFs were too high, especially for BDEs 153, 154, and 183. Differences between BSAFs for individual fish were explained by differences in age, growth, and feeding behavior. On average, modeled BSAFs for barbel were 50% higher than those for bleak because of extra BFR uptake through sediment ingestion and older age of barbel specimens.
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