Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
Smidt, M. ; Smits, S. ; Bouwmeester, H. ; Hamers, F. ; Hellemons, A. ; Burbach, J.P.H. - \ 2004
Development 131 (2004)5. - ISSN 0950-1991 - p. 1145 - 1155.
nail-patella syndrome - lmx1b mutant mice - transcription factor - aphakia mice - limb development - lens development - homeobox gene - binding-site - neural-tube - midbrain
The mesencephalic dopamine (mesDA) system is involved in the control of movement and behavior. The expression of Pitx3 in the brain is restricted to the mesDA system and the gene is induced relatively late, at E11.5, a time when tyrosine hydroxylase (Th) gene expression is initiated. We show here that, in the Pitx3-deficient aphakia (ak) mouse mutant, the mesDA system is malformed. Owing to the developmental failure of mesDA neurons in the lateral field of the midbrain, mesDA neurons are not found in the SNc and the projections to the caudate putamen are selectively lost. However, Pitx3 is expressed in all mesDA neurons in control animals. Therefore, mesDA neurons react specifically to the loss of Pitx3. Defects of motor control where not seen in the ak mice, suggesting that other neuronal systems compensate for the absence of the nigrostriatal pathway. However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation.
Long-term impairment of social memory in the rat after social defeat is not restored by desglycinamide-vasopressin
Reijmers, L.G.J.E. ; Hoekstra, K. ; Burbach, J.P.H. ; Ree, J.M. van; Spruijt, B.M. - \ 2001
Neuroscience Letters 305 (2001). - ISSN 0304-3940 - p. 145 - 148.
Repeated social defeat followed by individual housing caused a long-term impairment of social memory in male rats. Social memory, as assessed in the social discrimination test using an intertrial interval of 3 min, was impaired for at least 8 weeks after the social defeat experience. Since social memory of male rodents depends on proper functioning of the sexually dimorphic vasopressin system, it was investigated whether a centrally active vasopressin fragment could restore the impaired social memory. Subcutaneous administration of 6 g/kg of the vasopressin fragment desglycinamide-vasopressin (VP1–8) 40 days after social defeat slightly improved social memory in both control and socially defeated rats. It is concluded that social defeat followed by individual housing caused a long-term impairment of social memory, which was not restored by treatment with VP1–8.
Social memory in the rat: circadian variation and effect of circadian rhythm disruption
Reijmers, L.G.J.E. ; Leus, I.E. ; Burbach, J.P.H. ; Spruijt, B.M. ; Ree, J.M. van - \ 2001
Physiology and Behavior 72 (2001). - ISSN 0031-9384 - p. 305 - 309.
Disruption of circadian rhythm can impair long-term passive avoidance memory of rats and mice. The present study investigated whether disruption of circadian rhythm can also impair social memory of male rats. Social memory was assessed using the social discrimination test, in which a short-term olfactory memory is formed by social interaction with a juvenile rat during a learning trial. After an intertrial interval, a retrieval trial is performed, in which social memory is expressed as a decreased attention paid to the same juvenile as compared to a new juvenile. First, the social memory at four different time points across the light–dark cycle was measured with an intertrial interval of 10 or 25 min. There was no significant circadian variation of social memory across the light–dark cycle. Subsequently, the effect of a -6 or 12-h phase shift on social memory was studied. These phase shifts were previously found to impair long-term passive avoidance memory. However, no effect of either phase shift was observed in the social discrimination test. It is concluded that the disruption of circadian rhythm had no effect on the social memory of rats. Differences between short-term social memory and long-term passive avoidance memory are discussed in relation to their apparent differential susceptibility to the effects of circadian rhythm disruption
Delayed effect of the vasopressin metabolite VP4-8 on the social memory of sexually naive male rats
Reijmers, L.G.J.E. ; Baars, A.M. ; Burbach, J.P.H. ; Spruijt, B.M. - \ 2001
Psychopharmacology 154 (2001)4. - ISSN 0033-3158 - p. 408 - 414.
Rationale: Endogenous vasopressin is involved in the social memory of the male rat and administration of exogenous vasopressin improves social memory. These findings are mainly based on studies using sexually experienced males that were tested in the social recognition test. Objective: The present study was aimed to establish whether the modulation of social memory by vasopressin fragments depends on the sexual experience of the male rat. For this purpose, the social discrimination test was used, since this test is more suitable than the social recognition test for measuring social memory in sexually naive males. Methods: Male rats were tested in the social discrimination test and treated subcutaneously with the vasopressin metabolite [pGlu4,Cyt6]vasopressin-(4-8) (VP4-8). VP4-8 shares with vasopressin the effects on memory processes but lacks the peripheral effects of vasopressin. Results: VP4-8 (1 μg/kg) acutely improved the social memory of sexually experienced male rats, confirming previous reports. However, in sexually naive males VP4-8 failed to improve social memory in doses ranging from 0.1 μg/kg to 1 μg/kg. Instead, 1 μg/kg VP4-8 or 6 μg/kg desglycinamide-vasopressin were found to exert a delayed effect in sexually naive rats. This delayed effect resulted in an improved social memory 2 days after administration. Conclusions: Vasopressin sensitisation is discussed as a possible underlying mechanism of the observed delayed effect of vasopressin fragments. It is concluded that in male rats sexual experience can influence the modulation of social memory by vasopressin.
Differential responses of phosphorylated mitogen-activated protein kinase and phosphorylated cyclic-AMP response element-binding protein immunoreactivity in the rat brain to sub-convulsive pentylenetetrazol
Reijmers, L.G.J.E. ; Hernando, F. ; Ree, J.M. van; Spruijt, B.M. ; Burbach, J.P.H. - \ 2000
Neuroscience 101 (2000)4. - ISSN 0306-4522 - p. 1023 - 1028.
Neurite outgrowth in Neuro 2A cells is stimulated by activation of melanocortin receptors.
Adan, R.A.H. ; Kraan, M. van de; Oosterom, J. ; Wiegant, V.M. ; Burbach, J.P.H. ; Gispen, W.H. - \ 1995
In: Proc. 25th Annual Meeting Society for Neuroscience. San Diego (1995) 228.7
Differential effects of melanocortin peptides on neural melanocortin receptors.
Adan, R.A.H. ; Oosterom, J. ; Wiegant, V.M. ; Burbach, J.P.H. ; Gispen, W.H. - \ 1995
In: Proc. 24th Annual meeting Society for Neuroscience. Miami Beach (1995) 220.4
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