- J.C. Fuhrmann (1)
- B. Führmann (1)
- U. Garczarek (1)
- M. Hoegaerden van (1)
- B. Hollebrands (1)
- D.M. Jacobs (1)
- H.J. Kamphuis (1)
- V. Lebreton (1)
- S. Peters (1)
- D. Rein (1)
- F.M. Rombouts (1)
- A.D. Strosberg (1)
- E.J.J. Velzen van (1)
- J.C. Wit de (1)
Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome
Jacobs, D.M. ; Fuhrmann, J.C. ; Dorsten, F.A. van; Rein, D. ; Peters, S. ; Velzen, E.J.J. van; Hollebrands, B. ; Draijer, R. ; Duynhoven, J.P.M. van; Garczarek, U. - \ 2012
Journal of Agricultural and Food Chemistry 60 (2012)12. - ISSN 0021-8561 - p. 3078 - 3085.
black tea - phenolic-compounds - health - gut - microbiota - biomarkers - urine - acid - microflora - modulation
Red wine and grape polyphenols are considered to promote cardiovascular health and are involved in multiple biological functions. Their overall impact on the human metabolome is not known. Therefore, exogenous and endogenous metabolic effects were determined in fasting plasma and 24 h urine from healthy male adults consuming a mix of red wine and grape juice extracts (WGM) for 4 days in a placebo-controlled, crossover study. Syringic acid, 3-hydroxyhippuric acid, pyrogallol, 3-hydroxyphenylacetic acid, and 3-hydroxyphenylpropionic acid were confirmed as the strongest urinary markers of WGM intake. Overall, WGM had a mild impact on the endogenous metabolism. Most noticeable were changes in several amino acids deriving from tyrosine and tryptophan. Reductions in the microbial metabolites p-cresol sulfate and 3-indoxylsulfuric acid and increases in indole-3-lactic acid and nicotinic acid were observed in urine. In plasma, tyrosine was reduced. The results suggest that short-term intake of WGM altered microbial protein fermentation and/or amino acid metabolism.
|A monoclonal antibody specific for conidia and mycelium wall layer of Penicillium and Aspergillus.
Fuhrmann, B. ; Lebreton, V. ; Hoegaerden, M. van; Kamphuis, H.J. ; Strosberg, A.D. - \ 1992
Microbiology and immunology 36 (1992). - p. 1 - 12.
|Chemflow detection of yeasts in soft drinks.
Breeuwer, P. ; Wit, J.C. de; Führmann, B. ; Rombouts, F.M. - \ 1989
Unknown Publisher - 26 p.