Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Losse bijlage bij rapport 'Onderzoek naar kritische succesfactoren voor een laag antibioticumgebruik bij vleeskuikens'
Wiegel, J. ; Holstege, M.M.C. ; Bouwstra, R.J. ; Lauwere, C.C. de; Kluivers-Poodt, M. ; Bokma-Bakker, M.H. - \ 2017
Wageningen : Wageningen UR Livestock Research (Livestock Research rapport 1065B) - 115
dierenwelzijn - dierlijke productie - vleeskuikens - pluimvee - diergezondheid - animal welfare - animal production - broilers - poultry - animal health
Onderzoek naar kritische succesfactoren voor een laag antibioticumgebruik bij vleeskuikens: rapport van het project Kritische Succesfactoren Pluimvee (KSF Pluimvee)
Bokma-Bakker, M.H. ; Wiegel, J. ; Holstege, M.M.C. ; Lauwere, C.C. de; Kluivers-Poodt, M. ; Bouwstra, R.J. - \ 2017
Wageningen : Wageningen UR Livestock Research (Livestock Research rapport 1065A) - 78
dierenwelzijn - dierlijke productie - diergezondheid - pluimvee - vleeskuikens - animal welfare - animal production - animal health - poultry - broilers
Commissioned by AVINED and the Ministry of Agriculture, Nature and Food Quality, research is carried out to identify critical success factors for low antibiotic use in broilers. By analysis of sectoral databases, associations between farm and flock characteristics and antibiotics use are determined. With the results of an additional survey, differences in technical and social factors between structural low and high users of antibiotics are examined.
Temporal and spatial analysis of psittacosis in association with poultry farming in the Netherlands, 2000-2015
Hogerwerf, Lenny ; Holstege, Manon M.C. ; Benincà, Elisa ; Dijkstra, Frederika ; Hoek, Wim van der - \ 2017
Bmc Infectious Diseases 17 (2017)1. - ISSN 1471-2334
Avian chlamydiosis - Poultry - Psittacosis - Spatial analysis - Zoonosis
Background: Human psittacosis is a highly under diagnosed zoonotic disease, commonly linked to psittacine birds. Psittacosis in birds, also known as avian chlamydiosis, is endemic in poultry, but the risk for people living close to poultry farms is unknown. Therefore, our study aimed to explore the temporal and spatial patterns of human psittacosis infections and identify possible associations with poultry farming in the Netherlands. Methods: We analysed data on 700 human cases of psittacosis notified between 01-01-2000 and 01-09-2015. First, we studied the temporal behaviour of psittacosis notifications by applying wavelet analysis. Then, to identify possible spatial patterns, we applied spatial cluster analysis. Finally, we investigated the possible spatial association between psittacosis notifications and data on the Dutch poultry sector at municipality level using a multivariable model. Results: We found a large spatial cluster that covered a highly poultry-dense area but additional clusters were found in areas that had a low poultry density. There were marked geographical differences in the awareness of psittacosis and the amount and the type of laboratory diagnostics used for psittacosis, making it difficult to draw conclusions about the correlation between the large cluster and poultry density. The multivariable model showed that the presence of chicken processing plants and slaughter duck farms in a municipality was associated with a higher rate of human psittacosis notifications. The significance of the associations was influenced by the inclusion or exclusion of farm density in the model. Conclusions: Our temporal and spatial analyses showed weak associations between poultry-related variables and psittacosis notifications. Because of the low number of psittacosis notifications available for analysis, the power of our analysis was relative low. Because of the exploratory nature of this research, the associations found cannot be interpreted as evidence for airborne transmission of psittacosis from poultry to the general population. Further research is needed to determine the prevalence of C. psittaci in Dutch poultry. Also, efforts to promote PCR-based testing for C. psittaci and genotyping for source tracing are important to reduce the diagnostic deficit, and to provide better estimates of the human psittacosis burden, and the possible role of poultry.
Inventarisatie behoefte nieuwe testen voor uiergezondheidsmanagement. 1Health4Food DOT: Diagnostiek Ontwikkeling en Toepassing voor het optimaliseren van uiergezondheid
Griffioen, K. ; Hop, G. ; Wal, F.J. van der; Velthuis, A. ; Mevius, D.J. ; Lam, T. ; Cornelissen, J.B.W.J. ; Heuvelink, A. ; Achterberg, R.P. ; Holstege, M. ; Scherpenzeel, C. ; Berends, I. ; Dijkman, R. ; Smits, C.B. - \ 2015
CVI / GD
Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function
Outchkourov, N.S. ; Muino Acuna, J.M. ; Kaufmann, K. ; IJken, W.F.J. ; Groot Koerkamp, M.J. ; Leenen, D. van; Graaf, P. de; Holstege, F.C.P. ; Grosveld, F. ; Timmers, H.T.M. - \ 2013
Cell Reports 3 (2013)4. - ISSN 2211-1247 - p. 1071 - 1079.
little-imaginal-discs - embryonic stem-cells - binding-protein 2 - gene-expression - distinct functions - self-renewal - human genome - transcription - differentiation - reveals
The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes such as enhancers and promoters differ in their extent of methylation of histone H3 at lysine-4 (H3K4), but it is largely unknown how the different methylation states are specified and controlled. Here, we show that the Kdm5c/Jarid1c/SMCX member of the Kdm5 family of H3K4 demethylases can be recruited to both enhancer and promoter elements in mouse embryonic stem cells and in neuronal progenitor cells. Knockdown of Kdm5c deregulates transcription via local increases in H3K4me3. Our data indicate that by restricting H3K4me3 modification at core promoters, Kdm5c dampens transcription, but at enhancers Kdm5c stimulates their activity. Remarkably, an impaired enhancer function activates the intrinsic promoter activity of Kdm5c-bound distal elements. Our results demonstrate that the Kdm5c demethylase plays a crucial and dynamic role in the functional discrimination between enhancers and core promoters
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