Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Modelinstrumentarium toelating Gewasbeschermingsmiddelen (TOXSWA) (2018). Tussenrapportage WOT-04-008-024.
Horst, M.M.S. ter; Beltman, W.H.J. ; Adriaanse, P.I. ; Berg, F. van den - \ 2018
WOT Natuur & Milieu (WOt-interne notitie 232)
Manual for FOCUS_TOXSWA v5.5.3 and for expert use of TOXSWA kernel v3.3 : user’s guide version 5
Beltman, W.H.J. ; Horst, M.M.S. ter; Adriaanse, P.I. ; Jong, A. de - \ 2018
Wageningen : Statutory Research Tasks Unit for Nature & the Environment (WOt-technical report 126) - 148
The FOCUS_TOXSWA model calculates exposure concentrations of pesticides and their metabolites in watercourses and ponds, of the so-called FOCUS surface water scenarios. These concentrations are used in the pesticide registration procedure at EU level. The model concepts of TOXSWA are described briefly. The procedure for using the TOXSWA kernel (i.e. expert use) and related input files and output files are described. Concerning FOCUS_TOXSWA, the use of the graphical user interface to access the input and output is described. Input data are stored in a database. Pesticide entries resulting from drainage or runoff/erosion are accessed from separate files generated by FOCUS_MACRO and FOCUS_PRZM. Substance properties are accessed from the SPIN tool/database. Instructions for simulating a water-sediment study and a multi-year run are given.
Pesticide management in Rwanda : analysis of the current pest control products administration and management system
Wipfler, Louise ; Horst, Mechteld ter - \ 2018
Wageningen : Wageningen Environmental Research (Wageningen Environmental Research report 2904) - 37
This report describes the assessment of the current pest control products administration and management system in Rwanda. The assessment includes the aspects pesticide registration and evaluation, inspection and control and waste management. Roles, responsibilities and capacities of the public institutions involved are evaluated and current Rwandan legislations, regulations and procedures on pest control products are reviewed based on a series of consults and/or interviews with public and private institutions, actors and stakeholders in Rwanda. Finally, a set of observations and recommendations for improvement is provided based on the assessment.
Use of models for the environmental risk assessment of veterinary medicines in European aquaculture : Current situation and future perspectives
Rico, Andreu ; Vighi, Marco ; Brink, Paul J. van den; Horst, Mechteld ter; Macken, Ailbhe ; Lillicrap, Adam ; Falconer, Lynne ; Telfer, Trevor C. - \ 2018
Reviews in Aquaculture (2018). - ISSN 1753-5123
Antimicrobials - Antiparasitics - Aquaculture - Environmental models - Environmental risk assessment

Veterinary Medicinal Products (VMPs) are used in intensive aquaculture production to treat a wide range of bacterial and parasitic infestations. Their release into the environment poses concerns regarding their potential ecotoxicological risks to aquatic ecosystems, which need to be evaluated making use of appropriate Environmental Risk Assessment (ERA) schemes and models. This study presents an overview of the major aquaculture production systems in Europe, the VMPs most commonly used, and the environmental quality standards and regulatory procedures available for their ERA. Furthermore, it describes the state-of-the-art on the development of environmental models capable of assessing the fate, exposure, ecotoxicological effects and risks of VMPs in aquaculture production systems, and discusses their level of development and implementation within European aquaculture. This study shows that the use of environmental models in regulatory ERA is somewhat limited in many European countries. Major efforts have been dedicated to assess the fate and exposure of antiparasitic compounds in salmonid cage systems, particularly in Scotland, while models and scenarios for assessing dispersal of antimicrobials, in general, and antiparasitic compounds in the Mediterranean as well as in Scandinavian regions are less available. On the other hand, the use of ecological models for assessing the effects and risks of VMPs is almost absent. Recommendations are provided to improve the chemical exposure and effect assessments and the ecological realism of the modelling outcomes, paying special attention to the protection goals set for the regulatory ERA of VMPs in Europe.

Gewassen in de overlevingsmodus
Zondag, Harold - \ 2018
Scenarios for exposure of aquatic organisms to plant protection products in the Netherlands : Part 2: Sideways and upward spraying in Dutch fruit crops (interim report)
Boesten, J.J.T.I. ; Holterman, H.J. ; Wipfler, L. ; Horst, M.M.S. ter; Zande, J.C. van de; Adriaanse, P.I. - \ 2018
Wageningen : Wageningen Environmental Research (Wageningen Environmental Research report 2861) - 55
A methodology is presented to assess the exposure of aquatic organisms resulting from pesticide applications by sideways and upward spraying in Dutch fruit crops. It is the intention that this methodology will be used in Dutch pesticide registration. The methodology is based on the principle that the endpoint concentration represents a 90th percentile of the statistical population of concentrations to be expected in ditches alongside fruit crops. Furthermore the methodology is founded on the principle that the user should be able to choose between different drift-reduction technology (DRT) classes and between different widths of the crop-free buffer zone. Spray drift is the only exposure route considered in the methodology. The 90th percentile concentration (PEC90) is based on a spatially distributed model that simulates the frequency distribution of the annual maximum concentration of more than 70,000 spatial units (i.e. ditches characterised by waterbody properties and their orientation with respect to the direction of the rows of the fruit trees and to the N-E-S-W direction) for 100 simulation years. This frequency distribution was calculated for different application patterns, different DRT classes and different widths of the crop-free buffer zone. Next, one of the 70,000 spatial units was selected which fulfilled the criterion that it could be used to calculate this PEC90 for all combinations of application patterns, DRT classes and widths by selecting a suitable percentile of its temporal distribution of concentrations. The TOXSWA model (coupled to the hydrological SWQN model simulating water depths and water flow rates) was parameterised for this selected spatial unit to run for 26 years. The first six years were used as a ‘warming-up’ period and the remaining 20 years for assessing the required temporal percentile. The scenario ditch was 300 m long of which only the 100 m in the middle received a drift load of pesticide. The direction of water flow may change on a daily basis and the water flowing into the 300-m ditch was assumed to be free of pesticide. The median residence time of a droplet of water in the 100-m ditch was about 1 day. The
spray drift deposition for the 99% DRT class appeared to be as low as 0.03-
0.07% for summer applications. At such low deposition levels the contribution of leaching from drain pipes and of atmospheric deposition may exceed that of the drift deposition.
Risk reduction of pesticides in Myanmar : interim report of the Dutch-Myanmar project of pesticide registration and pesticide risk reduction 2016-2018
Horst, Mechteld ter; Deneer, John ; Valk, Harold van der; Kyaw Oo, Aung ; San Lwin, San ; Raw, Sen ; Krook, Janhendrik - \ 2018
Wageningen : Wageningen Environmental Research (Wageningen Environmental Research report 2879) - 143
Ditch parameterisation for the aquatic exposure assessment of plant protection products in the Netherlands by sideways and upward spraying in fruit orchards
Wipfler, Louise ; Horst, Mechteld ter; Massop, Harry ; Walvoort, Dennis - \ 2018
Wageningen : Wageningen Environmental Research (Wageningen Environmental Research rapport 2850) - 107
History and Institutions in the Rebuilding of Social Capital after Forced Resettlement in the Philippines and Indonesia
Navarra, Melissa Quetulio ; Niehof, Anke ; Vaart, Wander van der; Horst, Hilje van der; Moerbeek, Hester - \ 2018
Journal of Development Studies 54 (2018)8. - ISSN 0022-0388 - p. 1392 - 1405.

Resettlement results in the loss of social capital from which poor households can draw resources for sustenance, survival and wellbeing. While Putnam deems social capital formation as pre-determined by a community’s history of civic engagement, the institutional view argues that social capital is generated through the institutions’ interventions. Utilising a comparative approach involving two resettlement sites, one in the Philippines and one in Indonesia, this article presents findings on the explanatory power of these two perspectives. The Philippine case is greatly influenced by the institutional interventions while the Indonesian case testifies to the validity of the theoretical perspective of Putnam.

Nullozing: hoe moet dat en wat kan er?
Os, Erik van - \ 2017
An assessment of policies affecting Sustainable Soil Management in Europe and selected member states
Turpin, Nadine ; Berge, Hein ten; Grignani, Carlo ; Guzmán, Gema ; Vanderlinden, Karl ; Steinmann, Horst-Henning ; Siebielec, Grzegorz ; Spiegel, Adelheid ; Perret, Eric ; Ruysschaert, Greet ; Laguna, Ana ; Giráldez, Juan Vicente ; Werner, Magdalena ; Raschke, Isabell ; Zavattaro, Laura ; Costamagna, Chiara ; Schlatter, Norman ; Berthold, Helen ; Sandén, Taru ; Baumgarten, Andreas - \ 2017
Land Use Policy 66 (2017). - ISSN 0264-8377 - p. 241 - 249.
This paper analyses soils-related policies in Europe and in selected member states and regions. Our approach breaks down policy packages at European, national and regional levels into strategic objectives, operational objectives, policy measures and expected impacts, and assesses the relationships between these elements and soil stakes. Four major policy packages, both at EU and national level (CAP-I, RDP, Environment, national initiatives) were analysed. A numerical scale was developed to quantify the level of “embeddedness” of soil stakes in these policy packages. We found that countries better embed soil stakes into their policies when they also put more efforts on environmental innovation. In turn, countries with a high embeddedness level, with high trust in European institutions and that make more efforts towards renewable energy, tend to propose a wider variety of management practices to farmers for dealing with soil stakes.
Preventie van ijzer- en vitamine D deficiëntie bij West-Europese peuteurs: een RCT met verrijkte peutermelk
Marjolijn, Akkermans ; Brus, F. ; Goudoever, H. van; Elburg, Ruurd M. Van; Eussen, Simone ; Horst, Judith van der - \ 2017
Modelinstrumentarium Toelating Gewasbeschermingsmiddelen en Biociden (TOXSWA) : Tussenrapportage WOT-04-008-024
Horst, M.M.S. ter; Beltman, W.H.J. ; Adriaanse, P.I. ; Berg, F. van den - \ 2017
Wageningen : Wettelijke Onderzoekstaken Natuur & Milieu (WOt-interne notitie 187)
Extra maïs in rantsoen vormt risico voor hardere kazen
Dijkstra, Jan - \ 2017
Hydrolysis and biotic transformation in water in the pesticide model : Implementation report
Horst, M.M.S. ter; Beltman, W.H.J. ; Adriaanse, P.I. ; Mulder, H.M. - \ 2017
Wageningen : Wageningen Environmental Research (Wageningen Environmental Research rapport 2848) - 55
The TOXSWA model has been extended with the functionality to simulate hydrolysis and biotic transformation in water. TOXSWA simulates the fate of pesticides in water bodies to calculate exposure calculations for aquatic organisms or sediment-dwelling organisms as part of the aquatic risk assessment of pesticides. Hydrolysis and biotic transformation are modelled as first-order processes, occuring in the water phase only. The hydrolysis transformation rates are considered to be dependent on both pH and temperature. The biotic transformation rate is considered to be temperature-dependent only.
De meerwaarde van watersportactiviteiten voor mensen met een beperking
Nieuwenhuizen, Jeroen van den; Jonge, F.H. de; Berends, Eva ; Horst, Milou van der; jong, Nynke de; Jonkers, Ilonka ; Liem, Windy Mulia ; Nimwegen, Judith van; Agro, Prince Pascal ; Peters, Saskia ; Pol, Ellen van der; Schmitz, Paulina ; Sluimer, Nienke ; Wagenaar, Marlijn - \ 2017
Wageningen : Wageningen University & Research, Wetenschapswinkel (Wetenschapswinkel rapport 337) - ISBN 9789463432139 - 28
The social dynamics of smart grids : On households, information flows & sustainable energy transitions
Naus, Joeri - \ 2017
University. Promotor(en): Gert Spaargaren, co-promotor(en): Bas van Vliet; Hilje van der Horst. - Wageningen : Wageningen University - ISBN 9789463436977 - 234
households - sustainable energy - energy consumption - supply - energy policy - netherlands - huishoudens - duurzame energie - energiegebruik - aanbod - energiebeleid - nederland

In international climate and energy policy the development of smart grids features as a critical new step in the transition towards a sustainable energy future. Smart grids enable two-way energy and information exchange between households and energy providers. Drawing on social practice theories, transition theories and informational governance, this thesis seeks to shed light on the changes that are taking place at the level of households: How do householders understand, handle and use new information flows? How can we conceptualise the interplay between households and smart energy systems? And what does this mean for householder participation in smart energy transitions? The thesis suggests that the key to understanding and governing the social dynamics of smart grids lies in the ‘Home Energy Management-practices’ (HEM-practices) that are emerging at the interface between households and wider energy systems.

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis
Domínguez-Andrés, Jorge ; Arts, Rob J.W. ; Horst, Rob ter; Gresnigt, Mark S. ; Smeekens, Sanne P. ; Ratter, Jacqueline M. ; Lachmandas, Ekta ; Boutens, Lily ; Veerdonk, Frank L. van de; Joosten, Leo A.B. ; Notebaart, Richard A. ; Ardavín, Carlos ; Netea, Mihai G. - \ 2017
PLoS Pathogens 13 (2017)9. - ISSN 1553-7366 - 23 p.

Monocytes are innate immune cells that play a pivotal role in antifungal immunity, but little is known regarding the cellular metabolic events that regulate their function during infection. Using complementary transcriptomic and immunological studies in human primary monocytes, we show that activation of monocytes by Candida albicans yeast and hyphae was accompanied by metabolic rewiring induced through C-type lectin-signaling pathways. We describe that the innate immune responses against Candida yeast are energy-demanding processes that lead to the mobilization of intracellular metabolite pools and require induction of glucose metabolism, oxidative phosphorylation and glutaminolysis, while responses to hyphae primarily rely on glycolysis. Experimental models of systemic candidiasis models validated a central role for glucose metabolism in anti-Candida immunity, as the impairment of glycolysis led to increased susceptibility in mice. Collectively, these data highlight the importance of understanding the complex network of metabolic responses triggered during infections, and unveil new potential targets for therapeutic approaches against fungal diseases.

Unravelling the genetic base of the meiotic recombination landscapes in two varieties of the button mushroom, Agaricus bisporus
Sedaghat Telgerd, Narges - \ 2017
University. Promotor(en): Richard Visser, co-promotor(en): Anton Sonnenberg. - Wageningen : Wageningen University - ISBN 9789463436953 - 142
fungi - agaricus bisporus - mushrooms - genetics - breeding - meiosis - recombination - schimmels - paddestoelen - genetica - veredelen - meiose - recombinatie

The button mushroom, Agaricus bisporus var. bisporus, is one of the most cultivated mushrooms worldwide. Even though wild isolates of this variety have a broad genetic variation, the traditional and present-day hybrids only have a very narrow genetic base. The button mushroom has a typical meiotic recombination landscape (MRL) in which crossover (CO) events are predominantly restricted to the extreme ends of the chromosomes. This has been one of the main obstacles for mushroom breeders in improving or generating new mushroom hybrids due to a considerable linkage drag. A wild variety of A. bisporus, i.e., burnettii appeared to have CO spread more evenly across the genome. The existence of two extremely different MRLs in two compatible A. bisporus varieties offers an excellent opportunity to study the genetic basis for positioning CO in meiosis. The main objective of the research presented in this thesis initially was to examine meiosis of the var. burnettii in more detail and subsequently to identify genomic regions revealing the difference in MRL of the two A. bisporus varieties. The availability of genome sequences in the bisporus variety has produced many more informative markers such as SNP. We aimed to de novo sequence one of the haplotypes of a heterokaryotic strain of the burnettii variety using the PacBio sequencing technique and resequencing the other haplotype using Illumina HiSeq. In parallel to this, we used Genotyping by Sequencing (GBS) to construct the first linkage map of the burnettii variety, showing a more or less even distribution of COs across the genome. The constructed linkage map has also proved to be a useful tool for de novo assembly of the burnettii variety genome sequence. In addition, we performed comparative genome sequence studies between the burnettii variety and the previously sequenced genomes of two of the bisporus variety homokaryons, indicating high levels of collinearity between all three genomes. The only chromosomal rearrangement to be found was on chromosome 10, where an inversion of ~ 800 kb in the burnettii variety was detected compared to the var. bisporus genomes. As a starting point for unravelling the genetic basis underlying MRL in the A. bisporus, we performed quantitative trait loci (QTL) analysis using bisporus and burnettii varieties. An inter-varietal population was developed from a cross between a constituent nucleus of the bisporus and the burnettii variety. This population contains 178 haploid progenies which were genotyped by 210 SNP markers to construct a genetic linkage map, which proves to be a solid foundation for exploring the genetic control of MRL of A. bisporus. In addition, we performed a comparative genetic mapping study using the genetic maps of the bisporus variety Horst U1, the burnettii variety Bisp119/9 and the inter-varietal hybrid by selecting markers having similar positions in these three maps. In contrast to the bisporus variety where CO events are mainly restricted to chromosome ends, the burnettii variety shows a more or less equal distribution of CO events across the entire genome. The recombination landscape of the inter-varietal hybrid shows an intermediate pattern to that of both varieties. The MRL trait is expressed as a CO event in the offspring of each individual of the inter-varietal mapping population. For this reason, the individuals of the inter-varietal mapping population were intercrossed and outcrossed to generate three types of second generation hybrids. Two compatible tester homokaryons derived from the bisporus and burnettii varieties were used for outcrossing. Subsequently, the haploid progenies from each type of second generation hybrids were isolated to generate three types of segregating populations. The haploid progenies from segregating populations were genotyped with SNP markers covering the whole length of all the chromosomes. Recombination frequencies were determined at distal ends and elsewhere on the chromosomes and used to compare recombination frequencies between chromosomes within each population as well as between segregating populations across all chromosomes. A prerequisite for successful QTL mapping the MRL is to select segregating populations in which the segregation of MRL is clear. We observed that segregating populations outcrossed with the bisporus tester homokaryon were the most useful populations to generate haploid offspring in which COs are assessed for further QTL study of MRL at the time when this research was carried out. To map genomic regions involved in the different MRLs of A. bisporus, 71 homokaryotic offspring of the inter-varietal hybrid were outcrossed with an unrelated tester homokaryon of the bisporus variety. Subsequently, the haploid progenies were isolated from each hybrid and genotyped with SNP markers. Marker pairs were generated for the end regions of chromosomes to assess CO there or anywhere else on the chromosomes for each segregating population. QTL mapping analysis revealed two QTLs located on chromosome l and three others located on chromosomes IV, VI and VII. The QTLs identified span large parts of their respective chromosomes; therefore further strategies are needed for a more precise assessment and localisation of MRL.

The Heartbreak Bouquet - Developing Emotion Bouquets to Create Added Value
Hooge, I.E. de; Hanenberg, M.A.A. ; Horst, Gert J. ter; Verkerke, W. - \ 2017
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