Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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POLAR-guided signalling complex assembly and localization drive asymmetric cell division
Houbaert, Anaxi ; Zhang, Cheng ; Tiwari, Manish ; Wang, Kun ; Marcos Serrano, Alberto de; Savatin, Daniel V. ; Urs, Mounashree J. ; Zhiponova, Miroslava K. ; Gudesblat, Gustavo E. ; Vanhoutte, Isabelle ; Eeckhout, Dominique ; Boeren, Sjef ; Karimi, Mansour ; Betti, Camilla ; Jacobs, Thomas ; Fenoll, Carmen ; Mena, Montaña ; Vries, Sacco de; Jaeger, Geert De; Russinova, Eugenia - \ 2018
Nature 563 (2018)7732. - ISSN 0028-0836 - p. 574 - 578.

Stomatal cell lineage is an archetypal example of asymmetric cell division (ACD), which is necessary for plant survival1-4. In Arabidopsis thaliana, the GLYCOGEN SYNTHASE KINASE3 (GSK3)/SHAGGY-like kinase BRASSINOSTEROID INSENSITIVE 2 (BIN2) phosphorylates both the mitogen-activated protein kinase (MAPK) signalling module5,6 and its downstream target, the transcription factor SPEECHLESS (SPCH)7, to promote and restrict ACDs, respectively, in the same stomatal lineage cell. However, the mechanisms that balance these mutually exclusive activities remain unclear. Here we identify the plant-specific protein POLAR as a stomatal lineage scaffold for a subset of GSK3-like kinases that confines them to the cytosol and subsequently transiently polarizes them within the cell, together with BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE (BASL), before ACD. As a result, MAPK signalling is attenuated, enabling SPCH to drive ACD in the nucleus. Moreover, POLAR turnover requires phosphorylation on specific residues, mediated by GSK3. Our study reveals a mechanism by which the scaffolding protein POLAR ensures GSK3 substrate specificity, and could serve as a paradigm for understanding regulation of GSK3 in plants.

The importance of emotions in human-wildlife relationships
Jacobs, M.H. - \ 2018
A new model to Calibrate a Reference Standard for bovine tuberculin purified protein derivative in the target species
Frankena, Klaas ; Jacobs, Liesbeth ; Dijk, Tonny van; Good, Margaret ; Duignan, Anthony ; Jong, Mart C.M. de - \ 2018
Frontiers in Veterinary Science 5 (2018)OCT. - ISSN 2297-1769
Bovine international standard - Cattle - Guinea pigs - Mycobacterium bovis - New reference standard - Potency estimation - Tuberculin

Since 1986, use of a Bovine International Standard (BIS) for bovine tuberculin has been required to ensure national and international uniformity regarding the potency designation of bovine tuberculin Purified Protein Derivative (PPDb) preparations produced by multiple manufacturers. The BIS is the unique golden standard in the guinea pig potency assay, representing 100% potency, where potencies of production batches are calculated as relative potencies in comparison with the potency of the BIS which was set at 32,500 international Unit (IU) per mg. The stock supply and lifetime of the BIS is limited.The aim of this study was to develop a model to determine the potency of a newly produced in-house Reference Standard (RS) for PPDb with great accuracy in the target species (cattle) and to prove its precision and accuracy in the guinea pig potency test. First simulations were done to estimate the required number of cattle needed. Then, 30 naturally bTB infected cattle were subjected to a tuberculin skin test using multiple injections of both the RS and the BIS. Both were applied randomly in the same volume and concentration (1 dose). The potency of the RS against the BIS was directly derived from the least square means (LSMEANS) and was estimated as 1.067 (95% CI: 1.025-1.109), equal to a potency of 34,700 ± 1,400 IU/mg. In six guinea pig potency assays the RS was used to assign potencies to production batches of PPDb. Here, precision and accuracy of the RS was determined according to the parallel-line assay. Relative potencies were estimated by exponentiation of the common slope. The corresponding 95% confidence intervals were obtained according to Fieller's theorem. In sensitized guinea pigs, the relative potency of the RS against the BIS was 1.115 (95% CI: 0.871-1.432), corresponding to an absolute potency of 36,238 IU/mg (95% CI: 28,308-46,540).In conclusion: the method used to determine the potency of the RS against the BIS in naturally bTB infected cattle, resulted in a highly accurate potency estimate of the RS. The RS can be used in the guinea pig test to assign potencies to PPDb production batches with high precision and accuracy.

Nature-based training program fosters authentic leadership
Droffelaar, Boy van; Jacobs, M.H. - \ 2018
Journal of Leadership Studies (2018). - 12 p.
Authentic leadership is frequently promoted as a leadership style that responds to the contemporary challenges that leaders face. The current experimental study (n = 66) tested intrapersonal change toward authentic leadership after participation in a nature-based training program that included a stay in remote wilderness without any facilities. Authentic leadership was measured before, immediately after, and 1 year after the training program. All components of authentic leadership increased, namely self-awareness, internalized moral behavior, balanced processing, and relational transparency, with medium to large effect sizes (d ≈ .7). Changes in general personality traits were of a lower
magnitude, suggesting that change was specific to authentic leadership, rather than extending into general psychological characteristics. The findings emonstrate that a nature-based training program can increase authentic leadership. Immersion in wilderness is possibly conducive to change in
leadership style, and could be considered as a strategy for fostering leadership change.
A fruitful cooperation of urban meteorology and design. Results from the REALCOOL project
Jacobs, Cor - \ 2018
Urban Climate - water bodies
UV-filters and musk fragrances in seafood commercialized in Europe Union: Occurrence, risk and exposure assessment
Cunha, S.C. ; Trabalón, L. ; Jacobs, S. ; Castro, M. ; Fernandez-Tejedor, M. ; Granby, K. ; Verbeke, W. ; Kwadijk, C. ; Ferrari, F. ; Robbens, J. ; Sioen, I. ; Pocurull, E. ; Marques, A. ; Fernandes, J.O. ; Domingo, J.L. - \ 2018
Environmental Research 161 (2018). - ISSN 0013-9351 - p. 399 - 408.
fish - UV-filters - Musk fragrances - Occurrence - risk assessment - GC-MS/MS
In the framework of the FP7 ECsafeSeafood project, 62 seafood samples commercialized in Europe Union from several representative species – mackerel, tuna, salmon, seabream, cod, monkfish, crab, shrimp, octopus, perch
and plaice – were analysed for residues of 21 personal care products (PCPs), including 11 UV-filters (UV-Fs) and 10 musk fragrances (musks). PCPs analysis were performed by Quick, Easy, Cheap, Effective Rugged, Safe (QuEChERS), combined with liquid-liquid extraction (LLE) or dispersive solid-phase extraction (dSPE), followed by gas chromatography-tandem mass spectrometry (GC-MS/MS). The results showed the presence in a wide range of samples of nine out of eleven UV-Fs compounds analysed, namely 2-ethylhexyl salicylate (EHS), 2-
ethylhexyl,4-methoxycinnamate (EHMC), 4-methylbenzylidenecamphor (4-MBC), benzophenone-1 (BP1), benzophenone- 3 (BP3), isoamyl-4-methoxycinnamate (IMC), 2,2′-dihydroxy-4,4′-dimethoxybenzophenone (DHMB), homosalate (HS), and octocrylene (OC), whereas galaxolide (HHCB), galaxolide lactone (HHCB-lactone), and tonalide (AHTN) were the most found musks. The potential risks to human health associated with the exposure to eight of the more prevalent PCPs – EHS, EHMC, 4-MBC, BP1, BP3, IMC, HHCB, and AHTN - through seafood
consumption were assessed for consumers from five European countries (Belgium, Ireland, Italy, Portugal and Spain). Results showed that the human exposure to UV-Fs and musks estimated from the concentration values
found in seafood and the daily consumption of concerned seafood species, were far below toxicological reference values.
Pharmaceuticals and endocrine disruptors in raw and cooked seafood from European market : Concentrations and human exposure levels
Álvarez-Muñoz, Diana ; Rodríguez-Mozaz, Sara ; Jacobs, Silke ; Serra-Compte, Albert ; Cáceres, Nuria ; Sioen, Isabelle ; Verbeke, Wim ; Barbosa, Vera ; Ferrari, Federico ; Fernández-Tejedor, Margarita ; Cunha, Sara ; Granby, Kit ; Robbens, Johan ; Kotterman, Michiel ; Marques, Antonio ; Barceló, Damià - \ 2018
Environment International 119 (2018). - ISSN 0160-4120 - p. 570 - 581.
Cooking - Dietary exposure - Endocrine disruptors - Pharmaceuticals - Risk - Seafood

Pharmaceuticals (PhACs) and endocrine disrupting compounds (EDCs) are chemicals of emerging concern that can accumulate in seafood sold in markets. These compounds may represent a risk to consumers through effects on the human reproductive system, metabolic disorders, pathogenesis of breast cancer or development of microbial resistance. Measuring their levels in highly consumed seafood is important to assess the potential risks to human health. Besides, the effect of cooking on contaminant levels is relevant to investigate. Therefore, the objectives of this research were to study the presence and levels of PhACs and EDCs in commercially available seafood in the European Union market, to investigate the effect of cooking on contaminant levels, and to evaluate the dietary exposure of humans to these compounds through seafood consumption. A sampling survey of seafood from 11 European countries was undertaken. Twelve highly consumed seafood types were analysed raw and cooked with 3 analytical methods (65 samples, 195 analysis). PhACs were mostly not detectable or below quantification limits in seafood whereas EDCs were a recurrent group of contaminants quantified in the majority of the samples. Besides, cooking by steaming significantly increased their levels in seafood from 2 to 46-fold increase. Based on occurrence and levels, bisphenol A, methylparaben and triclosan were selected for performing a human exposure assessment and health risk characterisation through seafood consumption. The results indicate that the Spanish population has the highest exposure to the selected EDCs through seafood consumption, although the exposure via seafood remained below the current toxicological reference values.

'Teler moet weten wat groenbemester doet'
Kroonen-Backbier, Brigitte ; Molendijk, Leendert - \ 2018
Verdiepen in warmer water: een modelstudie naar watertemperaturen en het effect van diepte
Wilschut, L. ; Jacobs, C. ; Vrouwe, A. ; Heideveld, M. ; Kluck, J. - \ 2018
H2O online (2018). - 12
‘s Zomers zullen steeds vaker langere periodes van hitte gaan optreden. Wat heeft dit voor effect op de lokale watertemperatuur? En heeft het zin om waterpartijen te verdiepen? Met de Cool Water Tool is geprobeerd modelmatig greep te krijgen op deze vragen. De resultaten laten zien dat de watertemperaturen met klimaatverandering toenemen. Lokaal verdiepen heeft weinig effect op de gemiddelde watertemperatuur. Daarentegen neemt de lengte van de maximale aaneengesloten periode met watertemperaturen hoger dan 20 graden fors toe.
'Groenbemesterkeuze is een kwestie van je doel goed voor ogen hebben'
Kroonen-Backbier, Brigitte ; Molendijk, Leendert - \ 2018
Aardappeldemodag 2018 wil sterke schakels verbinden
Ampt-de Jong, Marieke ; Mol-van de Erve, Leanne ; Tramper, Marcel - \ 2018
Hypoglycaemia induces recruitment of non-classical monocytes and cytotoxic lymphocyte subsets in type 1 diabetes
Ratter, Jacqueline M. ; Rooijackers, Hanne M.M. ; Jacobs, Cor W.M. ; Galan, Bastiaan E. de; Tack, Cees J. ; Stienstra, Rinke - \ 2018
Diabetologia 61 (2018)9. - ISSN 0012-186X - p. 2069 - 2071.
Hypoglycaemia - Inflammation - Type 1 diabetes
Nuttige beestjes in beeld
Huiting, Hilfred - \ 2018
Comparative ecologic relationships of saturated fat, sucrose, food groups, and a Mediterranean food pattern score to 50-year coronary heart disease mortality rates among 16 cohorts of the Seven Countries Study
Kromhout, Daan ; Menotti, Alessandro ; Alberti-Fidanza, Adalberta ; Puddu, Paolo Emilio ; Hollman, Peter ; Kafatos, Anthony ; Tolonen, Hanna ; Adachi, Hisashi ; Jacobs, David R. - \ 2018
European Journal of Clinical Nutrition 72 (2018). - ISSN 0954-3007 - p. 1103 - 1110.

Background/objectives: We studied the ecologic relationships of food groups, macronutrients, eating patterns, and an a priori food pattern score (Mediterranean Adequacy Index: MAI) with long-term CHD mortality rates in the Seven Countries Study. Subjects/methods: Sixteen cohorts (12,763 men aged 40–59 years) were enrolled in the 1960s in seven countries (US, Finland, The Netherlands, Italy, Greece, former Yugoslavia: Croatia/Serbia, Japan). Dietary surveys were carried out at baseline and only in a subsample of each cohort. The average food consumption of each cohort was chemically analyzed for individual fatty acids and carbohydrates. Results: Ecologic correlations of diet were computed across cohorts for 50-year CHD mortality rates; 97% of men had died in cohorts with 50-year follow-up. CHD death rates ranged 6.7-fold among cohorts. At baseline, hard fat was greatest in northern Europe, olive oil in Greece, meat in the US, sweet products in northern Europe and the US, and fish in Japan. The MAI was high in Mediterranean and Japanese cohorts. The 50-year CHD mortality rates of the cohorts were closely positively ecologically correlated (r = 0.68–0.92) with average consumption of hard fat, sweet products, animal foods, saturated fat, and sucrose, but not with naturally occurring sugars. Vegetable foods, starch, and the a priori pattern MAI were inversely correlated (r = −0.59 to −0.91) with CHD mortality rates. Conclusions: Long-term CHD mortality rates had statistically significant ecologic correlations with several aspects of diet consumed in the 1960s, the traditional Mediterranean and Japanese patterns being rich in vegetable foods, and low in sweet products and animal foods.

Veel regen in korte tijd plaagt akkerbouwers
Hoekzema, Gerard - \ 2018
The cooling effect of small blue urban speces is negligible
Lenzholzer, S. ; Cortesão, J. ; Klok, L. ; Jacobs, C.M.J. ; Kluck, Jeroen - \ 2018
urban climate - water bodies
From diversity to justice – Unraveling pluralistic rationalities in urban design
Hartmann, Thomas ; Jehling, Mathias - \ 2018
Cities (2018). - ISSN 0264-2751
Cultural Theory - Economic goods - Grid and group - Justice - Leipzig - Urban space
For Jane Jacobs, the city is a fundamental unit of diversity; she develops her ideas in the city around this key axiom. Diversity provides an ethical orientation and thus defines what a just city should achieve. For Jacobs, justice is represented by peoples’ inherent right to ‘make cities’. According to Jacobs, cities become just places by their ability to facilitate the spontaneous dynamics among social fabrics and urban spaces to generate the beauty and value of cities. This contribution picks up this claim for diversity and develops a theoretical lens to explore how diversity is incorporated in urban design. We use a theory on pluralism—Cultural Theory—to analyse forms of managing urban space in different types of goods. This is applied to analyse four idealistic urban spaces in the city of Leipzig.
Playing language games: higher education quality dynamics in Dutch national policies since 1985
Weenink, Kasja ; Aarts, Noelle ; Jacobs, Sandra - \ 2018
Critical Policy Studies 12 (2018). - ISSN 1946-0171 - p. 273 - 293.
Higher education quality is a vague, ambiguous, multiple, and essentially contested concept. Quality’s contested character involves endless disputes about its proper use which makes it problematic to handle in governmental policies. Wittgenstein’s notion of language games is used to understand how, through time, higher education quality is enacted in Dutch governmental policy texts, and how its uses are related to each other. The analysis depicts various quality games interacting with different policy contexts, which show multiple enactments of quality as a unified concept alongside more differentiated uses. In the policy games, quality is not the focal notion. The games center around the steering relationship with the institutions, which are placed ‘at distance’. Through time, the games respond to increasing societal complexity and competition, and foster further flexibilization of institutional policies regarding quality and accessibility. In this management discourse with the institutions, quality is not used contrastively. It is concluded that quality’s vague and contradictory enactments and valuations are not problematic in the institutional steering relationship. Recent policy texts however relate quality’s ‘proper use’ to activities that enhance the student’s learning process. This draws attention to paradoxes for a distancing government in its role as a universal actor with societal responsibilities.
Weight loss moderately affects the mixed meal challenge response of the plasma metabolome and transcriptome of peripheral blood mononuclear cells in abdominally obese subjects
Fazelzadeh, Parastoo ; Hangelbroek, Roland W.J. ; Joris, Peter J. ; Schalkwijk, Casper G. ; Esser, Diederik ; Afman, Lydia ; Hankemeier, Thomas ; Jacobs, Doris M. ; Mihaleva, Velitchka V. ; Kersten, Sander ; Duynhoven, John van; Boekschoten, Mark V. - \ 2018
Metabolomics 14 (2018)4. - ISSN 1573-3882
Metabolic health - Mixed-meal challenge - Phenotype shift
Introduction: The response to dietary challenges has been proposed as a more accurate measure of metabolic health than static measurements performed in the fasted state. This has prompted many groups to explore the potential of dietary challenge tests for assessment of diet and lifestyle induced shifts in metabolic phenotype. Objectives: We examined whether the response to a mixed-meal challenge could provide a readout for a weight loss (WL)-induced phenotype shift in abdominally obese male subjects. The underlying assumption of a mixed meal challenge is that it triggers all aspects of phenotypic flexibility and provokes a more prolonged insulin response, possibly allowing for better differentiation between individuals. Methods: Abdominally obese men (n = 29, BMI = 30.3 ± 2.4 kg/m2) received a mixed-meal challenge prior to and after an 8-week WL or no-WL control intervention. Lean subjects (n = 15, BMI = 23.0 ± 2.0 kg/m2) only received the mixed meal challenge at baseline to have a benchmark for WL-induced phenotype shifts. Results: Levels of several plasma metabolites were significantly different between lean and abdominally obese at baseline as well as during postprandial metabolic responses. Genes related to oxidative phosphorylation in peripheral blood mononuclear cells (PBMCs) were expressed at higher levels in abdominally obese subjects as compared to lean subjects at fasting, which was partially reverted after WL. The impact of WL on the postprandial response was modest, both at the metabolic and gene expression level in PBMCs. Conclusion: We conclude that mixed-meal challenges are not necessarily superior to measurements in the fasted state to assess metabolic health. Furthermore, the mechanisms accounting for the observed differences between lean and abdominally obese in the fasted state are different from those underlying the dissimilarity observed during the postprandial response.
Effect of exercise on apparent total tract digestibility of nutrients and faecal recovery of ADL and TiO2 in ponies
Schaafstra, F.J.W.C. ; Doorn, D.A. van; Schonewille, J.T. ; Roelfsema, E. ; Westermann, C.M. ; Dansen, O. ; Jacobs, M. ; Lee, J.Y. ; Spronck, E.A. ; Blok, M.C. ; Hendriks, W.H. - \ 2018
Animal 12 (2018)12. - ISSN 1751-7311 - p. 2505 - 2510.
digestibility - equines - exercise - markers - total faeces collection
Exercise and physical training are known to affect gastrointestinal function and digestibility in horses and can lead to inaccurate estimates of nutrient and energy digestibility when markers are used. The effect of exercise on apparent nutrient digestibility and faecal recoveries of ADL and TiO2 was studied in six Welsh pony geldings subjected to either a low- (LI) or high-intensity (HI) exercise regime according to a cross-over design. Ponies performing LI exercise were walked once per day for 45 min in a horse walker (5 km/h) for 47 consecutive days. Ponies submitted to HI exercise were gradually trained for the same 47 days according a standardized protocol. Throughout the experiment, the ponies received a fixed level of feed and the daily rations consisted of 4.7 kg DM of grass hay and 0.95 kg DM of concentrate. The diet was supplemented with minerals, vitamins and TiO2 (3.0 g Ti/day). Total tract digestibility of DM, organic matter (OM), CP, crude fat, NDF, ADF, starch, sugar and energy was determined with the total faeces collection (TFC) method. In addition, DM and OM digestibility was estimated using internal ADL and the externally supplemented Ti as markers. Urine was collected on the final 2 days of each experimental period. Exercise did not affect apparent digestibility of CP, crude fat, starch and sugar. Digestibility of DM (DMD), OM (OMD), ADF and NDF tended to be lower and DE was decreased when ponies received the HI exercise regime. For all treatments combined, mean faecal recoveries of ADL and Ti were 87.8±1.7% and 99.3±1.7%, respectively. Ti was not detected in the urine, indicating that intestinal integrity was maintained with exercise. Dry matter digestibility estimated with the TFC, ADL and Ti for ponies subjected to LI exercise were 66.3%, 60.3% and 64.8%, respectively, while DMD for HI ponies were 64.2%, 60.3% and 65.2%, respectively. In conclusion, physical exercise has an influence on the GE digestibility of the feed in ponies provided with equivalent levels of feed intake. In addition, the two markers used for estimating apparent DMD and OMD indicate that externally supplemented Ti is a suitable marker to determine digestibility of nutrients in horses performing exercise unlike dietary ADL.
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