Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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A role for TLR10 in obesity and adipose tissue morphology
Boutens, Lily ; Mirea, Andreea Manuela ; Munckhof, Inge van den; Doppenberg-Oosting, Marije ; Jaeger, Martin ; Hijmans, Anneke ; Netea, Mihai G. ; Joosten, Leo A.B. ; Stienstra, Rinke - \ 2018
Cytokine 108 (2018). - ISSN 1043-4666 - p. 205 - 212.
Adipose tissue - Inflammation - Obesity - SNPs - TLR10
Toll like receptors (TLRs) are expressed in adipose tissue and promote adipose tissue inflammation during obesity. Recently, anti-inflammatory properties have been attributed to TLR10 in myeloid cells, the only member of the TLR family with inhibitory activity. In order to assess whether TLR10-induced inhibition of inflammation may be protective during the development of obesity and metabolic abnormalities we used transgenic human TLR10 mice (hTLR10tg) and wild type (WT) controls on a C57B6J background. HFD-feeding enhanced TLR10 expression in the adipose tissue, and HFD-fed hTLR10tg mice displayed reduced adipocyte size, adipose tissue weight, and a trend toward lower plasma insulin levels compared to WT mice. In humans, obese individuals with polymorphisms in the TLR10 gene displayed reduced macrophage infiltration in the adipose tissue accompanied by a trend to lower leptin levels and higher adiponectin levels in plasma. In healthy individuals with the same polymorphisms in the TLR10 gene we did not observe any difference in plasma concentrations of leptin and adiponectin. We conclude that TLR10 impacts adipose tissue morphology in obesity. Larger studies in humans are warranted to assess its potential value as therapeutic target in metabolic syndrome and type 2 diabetes.
Neochloris oleoabundans is worth its salt : Transcriptomic analysis under salt and nitrogen stress
Jaeger, Lenny de; Carreres, Benoit M. ; Springer, Jan ; Schaap, Peter J. ; Eggink, Gerrit ; Martins dos Santos, Vitor A.P. ; Wijffels, Rene H. ; Martens, Dirk E. - \ 2018
PLoS One 13 (2018)4. - ISSN 1932-6203
Neochloris oleoabundans is an oleaginous microalgal species that can be cultivated in fresh water as well as salt water. Using salt water gives the opportunity to reduce production costs and the fresh water footprint for large scale cultivation. Production of triacylglycerols (TAG) usually includes a biomass growth phase in nitrogen-replete conditions followed by a TAG accumulation phase under nitrogen-deplete conditions. This is the first report that provides insight in the saline resistance mechanism of a fresh water oleaginous microalgae. To better understand the osmoregulatory mechanism of N. oleoabundans during growth and TAG accumulating conditions, the transcriptome was sequenced under four different conditions: fresh water nitrogen-replete and -deplete conditions, and salt water (525 mM dissolved salts, 448mM extra NaCl) nitrogen-replete and -deplete conditions. In this study, several pathways are identified to be responsible for salt water adaptation of N. oleoabundans under both nitrogen-replete and -deplete conditions. Proline and the ascorbate-glutathione cycle seem to be of importance for successful osmoregulation in N. oleoabundans. Genes involved in Proline biosynthesis were found to be upregulated in salt water. This was supported by Nuclear magnetic resonance (NMR) spectroscopy, which indicated an increase in proline content in the salt water nitrogen-replete condition. Additionally, the lipid accumulation pathway was studied to gain insight in the gene regulation in the first 24 hours after nitrogen was depleted. Oil accumulation is increased under nitrogen-deplete conditions in a comparable way in both fresh and salt water. The mechanism behind the biosynthesis of compatible osmolytes can be used to improve N. oleoabundans and other industrially relevant microalgal strains to create a more robust and sustainable production platform for microalgae derived products in the future.
Diervriendelijker vissen met stroom
Rijnsdorp, Adriaan - \ 2017
Gene silencing of stearoyl-ACP desaturase enhances the stearic acid content in Chlamydomonas reinhardtii
Jaeger, L. de; Springer, J. ; Wolbert, E.J.H. ; Martens, D.E. ; Eggink, G. ; Wijffels, R.H. - \ 2017
Bioresource Technology 245 (2017)B. - ISSN 0960-8524 - p. 1616 - 1626.
Chlamydomonas reinhardtii - Enhanced stearic acid - RNA silencing

In this study, stearoyl-ACP desaturase (SAD), the enzyme that converts stearic acid into oleic acid, is silenced by artificial microRNA in the green microalga Chlamydomonas reinhardtii. Two different constructs, which target different positions on the mRNA of stearoyl-ACP desaturase, were tested. The mRNA levels for SAD were reduced after the silencing construct was induced. In one of the strains, the reduction in SAD mRNA resulted in a doubling of the stearic acid content in triacylglycerol molecules, which shows that stearic acid production in microalgae is possible.

Meer melk met big data
Kempenaar, Corne - \ 2017
Draft genome sequence of the oleaginous green alga Tetradesmus obliquus UTEX 393
Carreres, B.M. ; Jaeger, L. de; Springer, J. ; Barbosa, M.J. ; Breuer, G. ; End, E.J. van den; Kleinegris, D.M.M. ; Schäffers, I. ; Wolbert, E.J.H. ; Zhang, H. ; Lamers, P.P. ; Martins dos Santos, V.A.P. ; Wijffels, R.H. ; Eggink, G. ; Schaap, P.J. ; Martens, D.E. - \ 2017
Genome announcements 5 (2017)3. - ISSN 2169-8287

The microalgae Tetradesmus obliquus is able to maintain a high photosynthetic efficiency under nitrogen limitation and is considered a promising green microalgae for sustainable production of diverse compounds, including biofuels. Here, we report the first draft whole-genome shotgun sequencing of T. obliquus. The final assembly comprises 108,715,903 bp with over 1,368 scaffolds.

Modélisation de la croisssance végétale, les operateurs et croissance: cas déterministe
Reffye, P. de; Heuvelink, E. ; Letort, V. ; Kang, Mengzhen - \ 2016
In: Architecture at croissance des plantes. Modélisations at applications / De Reffye, Philippe, Jaeger, Marc, Barthélémy, Daniel, Houllier, François, Versailles Cedex : Éditions Quae - ISBN 9782759226221
Kweekvis moet op een visvrij dieet
Schrama, Johan - \ 2016
Modélisation de la croissance végétale, les operateurs de croissance: cas déterministe
Reffye, P. de; Heuvelink, E. ; Letort, V. ; Kang, M.Z. - \ 2016
In: Architecture et croissance des plantes. Modélisations et applications / De Reffye, P., Jaeger, M., Barthélémy, D., Houllier, F., Versailles : Éditions Quae - ISBN 9782759226221
Comment les plantes poussent-elles ? Le nombre d’or est-il omniprésent dans leur architecture ? Leurs structures sont-elles fractales ? Ont-elles un langage ? Une grammaire ? Il y a du vrai dans ces questions, mais il faut aller plus loin. Il faut identifier, modéliser et simuler le rôle des organes d’une plante dans sa croissance et leur fonctionnement.

La modélisation des plantes fait l’objet de recherches à l’interface de disciplines biologiques (botanique, agronomie, génétique, écophysiologie) des mathématiques appliquées et de l’informatique. Elle permet de créer les modèles de développement de l’architecture des plantes, mais aussi les modèles de production végétale, expression de la croissance des organes.

Les auteurs de cet ouvrage nous exposent les fondements biologiques, mathématiques et informatiques qui permettent d’exprimer le fonctionnement des bourgeons, la production photosynthétique de la biomasse et sa répartition dans les organes d’une plante. La simulation de la croissance des plantes devient alors possible sous la forme de modèles dynamiques et sa représentation, sous la forme d’images de synthèse. Ces modèles autorisent de multiples applications. De nombreuses plantes sont présentées (herbacées, arbustes et arbres) ; leur modélisation a une visée pratique en agriculture, en gestion des ressources naturelles et de l’environnement et en représentation des paysages.

Rédigé par des botanistes, des agronomes, des mathématiciens et des informaticiens, cet ouvrage collectif est le fruit de quarante années de recherches conduites par Philippe de Reffye et ses collègues, avec des collaborations scientifiques en France, en Hollande, en Chine et en Afrique. Il s’adresse aux chercheurs, enseignants et étudiants en biologie, en agronomie et en sciences de la vie, aux architectes paysagistes, écologues, qui s’intéressent à la croissance des plantes, à leur modélisation et à leur représentation. Il s’adresse aussi à toutes les communautés des sciences exactes (mathématiciens, informaticiens, physiciens) intéressées par la simulation du vivant.
Ce livre paraîtra au format papier et PDF en juin 2017.
Opgejaagd door de wind
Steeneveld, Gert-Jan - \ 2016

Wind bepaalt mede het klimaat in de stad. Ontwerpers kunnen daar maar beter rekening mee houden.

How effective is road mitigation at reducing road-kill? A meta-analysis
Rytwinski, Trina ; Soanes, Kylie ; Jaeger, Jochen A.G. ; Fahrig, Lenore ; Findlay, C.S. ; Houlahan, Jeff ; Ree, Rodney van der; Grift, Edgar A. van der - \ 2016
PLoS One 11 (2016)11. - ISSN 1932-6203

Road traffic kills hundreds of millions of animals every year, posing a critical threat to the populations of many species. To address this problem there are more than forty types of road mitigation measures available that aim to reduce wildlife mortality on roads (road-kill). For road planners, deciding on what mitigation method to use has been problematic because there is little good information about the relative effectiveness of these measures in reducing road-kill, and the costs of these measures vary greatly. We conducted a metaanalysis using data from 50 studies that quantified the relationship between road-kill and a mitigation measure designed to reduce road-kill. Overall, mitigation measures reduce roadkill by 40% compared to controls. Fences, with or without crossing structures, reduce roadkill by 54%. We found no detectable effect on road-kill of crossing structures without fencing. We found that comparatively expensive mitigation measures reduce large mammal road-kill much more than inexpensive measures. For example, the combination of fencing and crossing structures led to an 83% reduction in road-kill of large mammals, compared to a 57% reduction for animal detection systems, and only a 1% for wildlife reflectors. We suggest that inexpensive measures such as reflectors should not be used until and unless their effectiveness is tested using a high-quality experimental approach. Our meta-analysis also highlights the fact that there are insufficient data to answer many of the most pressing questions that road planners ask about the effectiveness of road mitigation measures, such as whether other less common mitigation measures (e.g., measures to reduce traffic volume and/or speed) reduce road mortality, or to what extent the attributes of crossing structures and fences influence their effectiveness. To improve evaluations of mitigation effectiveness, studies should incorporate data collection before the mitigation is applied, and we recommend a minimum study duration of four years for Before-After, and a minimum of either four years or four sites for Before-After-Control-Impact designs.

Letter to the editor: Financial complexity: Accounting for fraud—Response
Battiston, Stefano ; Farmer, D. ; Flache, Andreas ; Garlaschelli, Diego ; Haldane, Andy ; Heesterbeek, H. ; Hommes, C. ; Jaeger, C. ; May, R. ; Scheffer, M. - \ 2016
Science 352 (2016)6283. - ISSN 0036-8075 - p. 302 - 302.
Kweekvissen zijn vaak te vet
Palstra, Arjan - \ 2016

Veel kweekvissen zijn te vet, gestrest en ongezond, omdat ze te weinig beweging hebben. Een vis moet zwemmen.

Kweekvissen zijn vaak te vet
Palstra, Arjan - \ 2016

Veel kweekvissen zijn te vet, gestrest en ongezond, omdat ze te weinig beweging hebben. Een vis moet zwemmen.

The incidental influence of memories of past eating occasions on consumers' emotional responses to food and food-related behaviors
Piqueras-Fiszman, Betina ; Jaeger, Sara R. - \ 2016
Frontiers in Psychology 7 (2016)JUN. - ISSN 1664-1078
Affect infusion - Consumer research - Emotions - Food - Memory priming - Overeating - Recalled meals

Our memories of past eating experiences are influential in shaping food preferences and consumption behavior, and the emotions that people associate to these memories are linked to their attitudes toward foods and their everyday food-related behaviors. This work studies the impact that food-related memories have on peoples' emotional state and how this state is projected in a subsequent evaluation of images pertaining to food and food-related behaviors. Focus is placed on guilt and shame emotions. Through an online survey, three memories were investigated (a positive meal, a routine evening meal, and an overeating occasion) among UK consumers (N = 710). Participants primed with the overeating memory evaluated images related to junk food as conveying more feelings of guilt and shame than did participants primed with the memory of a positive meal. Moreover, this effect was moderated by participants' dietary restraint status. Participants classified as having a high dietary restraint had stronger associations with the emotions guilt and shame than participants classified as low in dietary restraint. In contrast, a memory of a positive meal did not lead to positive valuations of any of the food-related images shown. Overall, the findings from the present study illustrate the partial impact that personal food memories have on consumers' emotional response toward food-related issues, which in turn has the potential to affect future behavior. This study therefore contributes to the literature about cognitive effects on food attitudes and behavior. Furthermore, the results suggest that the empirical approach may be tapping into possibly unconscious emotions toward foods and food-related behavior.

Consumer segmentation as a means to investigate emotional associations to meals
Piqueras-Fiszman, Betina ; Jaeger, Sara R. - \ 2016
Appetite 105 (2016). - ISSN 0195-6663 - p. 249 - 258.
Consumer research - Consumer segments - Emotion associations - Food choice factors - Psychographics - Recalled meals

Consumers naturally associate emotions to meal occasions and understanding these can advance knowledge of food-related behaviours and attitudes. The present study used an online survey to investigate the emotional associations that people have with recalled meals: 'memorable' (MM) and 'routine' evening (RM). Heterogeneity in the studied consumer population (UK adults, n = 576 and 571, respectively) was accounted for using a data-driven approach to establish emotion-based segments. Two groups of people were identified with very different emotional response patterns to recalled meals. For 'memorable' and 'routine' meals the majority of people (Cluster 1) held strong positive and weak negative emotional associations. In Cluster 2, positive emotions remained more strongly associated than negative emotions, but much less so. In accordance with findings based on other response variables (e.g., preference, attitudes), psychographic variables accounted better for the heterogeneity found in the emotion associations than socio-demographic variables. Participants' level of meal engagement and difficulty in describing feelings (DDF scale) were the two most important predictors of cluster membership.

Complexity theory and financial regulation : Economic policy needs interdisciplinary network analysis and behavioral modeling
Battiston, Stefano ; Farmer, J.D. ; Flache, Andreas ; Garlaschelli, Diego ; Haldane, Andrew G. ; Heesterbeek, Hans ; Hommes, Cars ; Jaeger, Carlo ; May, Robert ; Scheffer, Marten - \ 2016
Science 351 (2016)6275. - ISSN 0036-8075 - p. 818 - 819.
Traditional economic theory could not explain, much less predict, the near collapse of the financial system and its long-lasting effects on the global economy. Since the 2008 crisis, there has been increasing interest in using ideas from complexity theory to make sense of economic and financial markets. Concepts, such as tipping points, networks, contagion, feedback, and resilience have entered the financial and regulatory lexicon, but actual use of complexity models and results remains at an early stage. Recent insights and techniques offer potential for better monitoring and management of highly interconnected economic and financial systems and, thus, may help anticipate and manage future crises.
Retained barred feathers in adult-summer Long-tailed Jaeger
Bemmelen, Rob S.A. van - \ 2015
Dutch Birding 37 (2015)2. - ISSN 0167-2878 - p. 92 - 94.
Micro-alg doet oliepalm na
Jaeger, L. de - \ 2015
Resource: weekblad voor Wageningen UR 10 (2015)5. - ISSN 1874-3625 - p. 9 - 9.
algen - plantaardige oliën - voedselbiotechnologie - genetisch gemanipuleerde organismen - spijsoliën - onderzoek - algae - plant oils - food biotechnology - genetically engineered organisms - edible oils - research
Veel plantaardige olie in ons dieet komt van palmolieplantages uit Zuidoost-Azië waarvoor regenwoud is gekapt. Promovendus Lenny de Jaeger zocht naar een alg die deze olie op duurzame wijze kan maken. Hij ontwikkelde een veelbelovende kandidaat.
Experimental study designs to improve the evaluation of road mitigation measures for wildlife
Rytwinski, T. ; Van der Ree, R. van der; Cunnington, G.M. ; Fahrig, L. ; Findlay, C.S. ; Houlahan, J. ; Jaeger, J.A.G. ; Soanes, K. ; Grift, E.A. van der - \ 2015
Journal of Environmental Management 154 (2015). - ISSN 0301-4797 - p. 48 - 64.
An experimental approach to road mitigation that maximizes inferential power is essential to ensure that mitigation is both ecologically-effective and cost-effective. Here, we set out the need for and standards of using an experimental approach to road mitigation, in order to improve knowledge of the influence of mitigation measures on wildlife populations. We point out two key areas that need to be considered when conducting mitigation experiments. First, researchers need to get involved at the earliest stage of the road or mitigation project to ensure the necessary planning and funds are available for conducting a high quality experiment. Second, experimentation will generate new knowledge about the parameters that influence mitigation effectiveness, which ultimately allows better prediction for future road mitigation projects. We identify seven key questions about mitigation structures (i.e., wildlife crossing structures and fencing) that remain largely or entirely unanswered at the population-level: (1) Does a given crossing structure work? What type and size of crossing structures should we use? (2) How many crossing structures should we build? (3) Is it more effective to install a small number of large-sized crossing structures or a large number of small-sized crossing structures? (4) How much barrier fencing is needed for a given length of road? (5) Do we need funnel fencing to lead animals to crossing structures, and how long does such fencing have to be? (6) How should we manage/manipulate the environment in the area around the crossing structures and fencing? (7) Where should we place crossing structures and barrier fencing? We provide experimental approaches to answering each of them using example Before-After-Control-Impact (BACI) study designs for two stages in the road/mitigation project where researchers may become involved: (1) at the beginning of a road/mitigation project, and (2) after the mitigation has been constructed; highlighting real case studies when available.
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