Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Correlation of instrumental texture properties from textural profile analysis (TPA) with eating behaviours and macronutrient composition for a wide range of solid foods
Wee, May Sui Mei ; Goh, Ai Ting ; Stieger, Markus ; Forde, Ciarán G. - \ 2018
Food & Function 9 (2018)10. - ISSN 2042-6496 - p. 5301 - 5312.

Faster eating rates have previously been associated with higher ad libitum energy intakes, and several studies have manipulated eating rates and intake by changing food textures. Food texture based changes to slow eating rates can produce reductions in energy intake without affecting post-meal satisfaction or re-bound hunger. However, an understanding of how specific food textures and instrumental texture properties influence oral processing behaviour remains limited. The current study sought to establish relationships between objective measures of oral processing behaviour (i.e. number of bites, average bite size, total chews, chews per bite, oro-sensory exposure time and eating rate) and instrumental measures of a food texture including hardness, adhesiveness, springiness, cohesiveness, chewiness, resilience and modulus. Across two studies, behavioural coding analysis was completed on video-recordings of participants consuming fixed portions of a wide range of different solid foods (n = 59) to derive objective measures of oral processing behaviours. These measures were correlated with instrumental Textural Profile Analysis (TPA) for the same set of foods. Significant correlations (p < 0.05) were found between oral processing parameters and texture properties (i.e. springiness, cohesiveness, chewiness and resilience). No significant correlations were found between hardness and modulus and oral processing parameters. Protein content of the food was associated with springiness and chewiness, which may help to further reduce eating rates. In terms of the ‘breakdown path model', hardness and modulus might represent degree of initial food structure while springiness, cohesiveness, chewiness and resilience seem to determine how fast the degree of structure is reduced to the swallowing plane. Water content and adhesiveness were associated with level of lubrication that is required before reaching the swallowing plane. The current study highlights opportunities to understand eating rate (g min−1) through the breakdown path model and the potential for specific features of a foods texture to influence rate and extent of energy intake. The correlation between instrumental texture properties and oral processing patterns provides guidance on the parameters that are likely to produce ‘faster' and ‘slower' versions of foods, and suggests how texture modifications could be applied to moderate eating rate and energy intake within meals.

WOt's new nummer 32, mei 2018
Cate, B. ten; Eimers, J.W. - \ 2018
Wageningen : WOT Natuur en Milieu - 4 p.
Functional analysis of the HD-Zip transcription factor genes Oshox12 and Oshox14 in rice
Shao, Jingxia ; Haider, Imran ; Xiong, Lizhong ; Zhu, Xiaoyi ; Hussain, Rana Muhammad Fraz ; Övernäs, Elin ; Meijer, Annemarie H. ; Zhang, Gaisheng ; Wang, Mei ; Bouwmeester, Harro J. ; Ouwerkerk, Pieter B.F. - \ 2018
PLoS One 13 (2018)7. - ISSN 1932-6203

The homeodomain-leucine zipper (HD-Zip) transcription factor family plays vital roles in plant development and morphogenesis as well as responses to biotic and abiotic stresses. In barley, a recessive mutation in Vrs1 (HvHox1) changes two-rowed barley to six-rowed barley, which improves yield considerably. The Vrs1 gene encodes an HD-Zip subfamily I transcription factor. Phylogenetic analysis has shown that the rice HD-Zip I genes Oshox12 and Oshox14 are the closest homologues of Vrs1. Here, we show that Oshox12 and Oshox14 are ubiquitously expressed with higher levels in developing panicles. Trans-activation assays in yeast and rice protoplasts demonstrated that Oshox12 and Oshox14 can bind to a specific DNA sequence, AH1 (CAAT(A/T)ATTG), and activate reporter gene expression. Overexpression of Oshox12 and Oshox14 in rice resulted in reduced panicle length and a dwarf phenotype. In addition, Oshox14 overexpression lines showed a deficiency in panicle exsertion. Our findings suggest that Oshox12 and Oshox14 may be involved in the regulation of panicle development. This study provides a significant advancement in understanding the functions of HD-Zip transcription factors in rice.

The Globodera pallida SPRYSEC Effector GpSPRY-414-2 That Suppresses Plant Defenses Targets a Regulatory Component of the Dynamic Microtubule Network
Mei, Yuanyuan ; Wright, Kathryn M. ; Haegeman, Annelies ; Bauters, Lander ; Diaz-Granados, Amalia ; Goverse, Aska ; Gheysen, Godelieve ; Jones, John T. ; Mantelin, Sophie - \ 2018
Frontiers in Plant Science 9 (2018). - ISSN 1664-462X
The white potato cyst nematode, Globodera pallida, is an obligate biotrophic pathogen of a limited number of Solanaceous plants. Like other plant pathogens, G. pallida deploys effectors into its host that manipulate the plant to the benefit of the nematode. Genome analysis has led to the identification of large numbers of candidate effectors from this nematode, including the cyst nematode-specific SPRYSEC proteins. These are a secreted subset of a hugely expanded gene family encoding SPRY domain-containing
proteins, many of which remain to be characterized. We investigated the function of one of these SPRYSEC effector candidates, GpSPRY-414-2. Expression of the
gene encoding GpSPRY-414-2 is restricted to the dorsal pharyngeal gland cell and reducing its expression in G. pallida infective second stage juveniles using RNA
interference causes a reduction in parasitic success on potato. Transient expression assays in Nicotiana benthamiana indicated that GpSPRY-414-2 disrupts plant defenses.
It specifically suppresses effector-triggered immunity (ETI) induced by co-expression of the Gpa2 resistance gene and its cognate avirulence factor RBP-1. It also causes
a reduction in the production of reactive oxygen species triggered by exposure of plants to the bacterial flagellin epitope flg22. Yeast two-hybrid screening identified a
potato cytoplasmic linker protein (CLIP)-associated protein (StCLASP) as a host target of GpSPRY-414-2. The two proteins co-localize in planta at the microtubules. CLASPs
are members of a conserved class of microtubule-associated proteins that contribute to microtubule stability and growth. However, disruption of the microtubule network does
not prevent suppression of ETI by GpSPRY-414-2 nor the interaction of the effector with its host target. Besides, GpSPRY-414-2 stabilizes its target while effector dimerization
and the formation of high molecular weight protein complexes including GpSPRY-414-2 are prompted in the presence of the StCLASP. These data indicate that the nematode
effector GpSPRY-414-2 targets the microtubules to facilitate infection.
Help, ik voel me zo schuldig!
Hooge, Ilona de - \ 2018
Herhaling is geen verspilling
Fischer, Arnout - \ 2018

Herhaling is geen verspilling

Veel vindingen in de moderne wetenschap worden ontkracht. Goede wetenschap koppelt nieuwe ontdekkingen aan precies uitzoeken hoe goed die ontdekking is. Dat komt vaak neer op twee stappen vooruit, en een stap terug. Herhalingsonderzoek is essentieel om uit te zoekem welke stap teruggezet moet worden.

De valversnelling die Tonie Mudde in Sir Edmund (26 mei) noemt is hier een mooi voorbeeld van. De impetustheorie , het idee dat iets pas gaat vallen als de beginsnelheid is uitgeput, is lang dominant geweest. Dit zien we nog in tekenfllms, bijvoorbeeld als Wile E. Coyote over de rand van een ravijn rent, vertraagt, blijft hangen en dan recht naar naar beneden valt.

Het waren herhalingen van val-experimenten door Galileo en anderen waardoor deze theorie werd verworpen. Gelukkkig werden die herhalingsstudies niet als verspilling van geld, energie en denkkracht gezien.

Stekende insecten Griendtsveen 2017 : notitie
Verdonschot, Piet F.M. ; Dekkers, T.B.M. - \ 2018
Wageningen : Zoetwaterecosystemen, Wageningen Environmental Research - ISBN 9789463432924 - 58
De inventarisatie van steekmuglarven leverde in 2016 4 kleinere gebiedsdelen op met hoge aantallen steekmuglarven (de zogenaamde ‘hotspots’). In april-mei 2017 is de larveninventarisatie herhaald. Hieruit bleek dat de larven van de moerassteekmug A. cinereus over het gehele gebied verspreid zijn met op de ‘hotspots’ opnieuw hoogste aantallen. In de periode daarna vielen de meeste locaties droog. Het jaar 2017 was een droog jaar waarbij al vroeg in het voorjaar, mogelijk zelfs in de winter, veel potentiële tijdelijke wateren al droog stonden. Het patroon van ontwikkeling van volwassen steekmuggen liet over 2017 een ‘klassiek’ beeld van een moerassteekmuggenpopulatie zien met hoge aantallen in het voorjaar die daarna snel uitdoven. Alleen in juni trad additioneel een kleine populatie van plantenboorsteekmuggen op. Dit beeld is een gevolg van het opdrogen van tijdelijke wateren in het gebied in het voorjaar. De in totaal lagere aantallen in het gehele gebied en de beperking van deze aantallen tot de maand mei hebben ertoe geleid dat in het dorp Griendtsveen in 2017 geen overlast is ervaren. De verdeling van de aantallen over de jaren 2015, 2016 en 2017 naar zone rondom en in het dorp laat zien dat er ieder jaar een afname van de aantallen optreedt richting de dorpskern. In de periode 2015-2017 is het aantallen verzamelde knutten toegenomen met een factor 3. Dit kan samenhangen met nattere weilanden aan de zuidzijde, in het dorp en aan de westzijde. De adviezen voor maatregelen om de ‘hotspots’ aan te pakken zijn in 2017 in gang gezet en ten dele uitgevoerd
A possible molecular basis for photoprotection in the minor antenna proteins of plants
Fox, Kieran F. ; Ünlü, Caner ; Balevičius, Vytautas ; Ramdour, Baboo Narottamsing ; Kern, Carina ; Pan, Xiaowei ; Li, Mei ; Amerongen, Herbert van; Duffy, Christopher D.P. - \ 2018
Biochimica et Biophysica Acta. B, Bioenergetics 1859 (2018)7. - ISSN 0005-2728 - p. 471 - 481.
Carotenoids - Light-harvesting - Minor antenna - Non-photochemical quenching - Photoprotection - Photosystem II

The bioenergetics of light-harvesting by photosynthetic antenna proteins in higher plants is well understood. However, investigation into the regulatory non-photochemical quenching (NPQ) mechanism, which dissipates excess energy in high light, has led to several conflicting models. It is generally accepted that the major photosystem II antenna protein, LHCII, is the site of NPQ, although the minor antenna complexes (CP24/26/29) are also proposed as alternative/additional NPQ sites. LHCII crystals were shown to exhibit the short excitation lifetime and several spectral signatures of the quenched state. Subsequent structure-based models showed that this quenching could be explained by slow energy trapping by the carotenoids, in line with one of the proposed models. Using Fluorescence Lifetime Imaging Microscopy (FLIM) we show that the crystal structure of CP29 corresponds to a strongly quenched conformation. Using a structure-based theoretical model we show that this quenching may be explained by the same slow, carotenoid-mediated quenching mechanism present in LHCII crystals.

Naar een verantwoord voedselsysteem, terugdringen Voedselverspilling als hefboom : Position paper tbv rondetafel Voedsel d.d. 5 april 2018
Timmermans, T. - \ 2018
Wageningen : Wageningen University & Research - 2
In mei 2017 is de eindbalans opgemaakt van de ambitie van de Nederlandse overheid om tussen 2009 en 2015 de hoeveelheid voedselverspilling met 20% te reduceren. Deze ambitie is niet gerealiseerd, ondanks de vele initiatieven en inzet vanuit een diversiteit van partijen.
Milieu-impact van twee verwerkingsroutes voor warme drankenbekers : vergisting en papierrecycling van karton-PLA koffiebekers
Lighthart, Tom ; Oever, Martien van den - \ 2018
Wageningen : Wageningen Food & Biobased Research (Wageningen Food &amp; Biobased Research report 1792) - ISBN 9789463438834 - 45
De Rijksoverheid gebruikt op dit moment warmedrankenbekers gemaakt uit papiervezels met een coating van PLA. Tot begin 2017 werden deze bekertjes na gebruik nog in de afvalenergiecentrale (AEC) verwerkt. Maar per 1 mei 2017 is er een pilot gestart met twee verschillende manieren van afvalverwerking:1. Collect a cup, waarbij de warmedrankenbekers door de firma Renewi (voorheen Van Gansewinkel) worden ingezameld en door papierfabriek WEPA Nederland B.V. (voorheen Van Houtum B.V.) worden verwerkt tot toiletpapier en tissues.2. Vergisting en compostering, waarbij de warme drankenbekers door Attero worden vergist, waarbij biogas ontstaat en de rest wordt gecomposteerd tot compost.De overheid wil inzicht in de duurzaamheid van deze beide verwerkingsroutes om een keuze te kunnen maken voor de meest duurzame. Wageningen Food and Biobased Research (WFBR) en TNO als onderaannemer hebben de opdracht gekregen om een studie uit te voeren waarin de milieu-impact van deze twee verwerkingsroutes voor warme drankenbekers worden vergeleken.De milieu-evaluatie omvat voor alle alternatieven dezelfde vergelijkingsbasis, die de functionele eenheid wordt genoemd. Aangezien deze eenheid voor alle onderscheiden systemen gelijk is, waarborgt het zo een gelijkwaardige vergelijking. De functionele eenheid is hierna gedefinieerd.Functionele eenheidDe inzameling, verwerking en recycling van 1000 door consumenten afgedankte koffiebekers, inclusief aanhangend vocht en vuil.De functionele eenheid bevat dus 1000 schone koffiebekers met daarnaast het aanhangende vocht en vuil, zoals productresten.Voor de milieu-evaluatie is de een veel gebruikte effectbeoordelingsmethode gebruikt: ReCiPe midpoints. Door deze methode te combineren met schaduwprijzen, die een milieueffect vertalen naar schade- ofwel schaduwkosten, kunnen alle milieueffectcategorieën worden uitgedrukt in een monetaire eenheid en daardoor kunnen de milieuprofielen van de alternatieven eenduidig met elkaar worden vergeleken. Vergeleken met ReCiPe endpoints, dat ook een geaggregeerde milieubelasting oplevert, is het voordeel dat deze methode waardevrij is en niet gebaseerd is op een waardeoordeel van een panel zoals voor de endpoints het geval is. Als alternatieve beoordelingsmethode is in dit rapport de Carbon footprint genomen vanwege de relevantie voor het beleid. Uit de resultaten van de milieu-analyse blijkt dat bij evaluatie van het volledige milieuprofiel de recyclingroute het beste presteert met €1,22 vermeden milieukosten per 1000 bekers. Dit mede dankzij dat 89% van de ingezamelde koffiebekers geschikt wordt bevonden voor recycling. De bekers met teveel verontreiniging worden in de afvalenergiecentrale verwerkt, waar energie wordt teruggewonnen. De vergistingsroute neemt met een milieuprestatie van €0,45 vermeden milieukosten de tweede plaats in en presteert beter dan verwerking van afgedankte bekers in de AEC (€0,28 vermeden milieukosten).Wanneer alleen naar het effect van klimaatverandering (CO2 uitstoot) wordt gekeken presteert de vergistingsroute het beste met een vermijding van 5,4 kg CO2-eq. per 1000 ingezamelde bekers. Dit alternatief wordt gevolgd door achtereenvolgens de AEC en daarna de recyclingroute. De recyclingroute presteert bij de Carbon footprint het minst, omdat het vermijden van primaire papierpulp een relatief geringe winst voor klimaatverandering oplevert.De komende (± 3) jaren zijn voor gecoate kartonnen koffiebekers geen andere verwerkingsroutes op industriële schaal te verwachten dan de nu toegepaste en onderzochte: vergisten tot biogas en recyclen tot papier, naast verbranden in een AEC. Eveneens worden geen significante verbeteringen in de technologieën verwacht. Wel zijn er andere bio-based warmedrankenbekers op de markt waarvan de milieuimpact tijdens productie en in de afvalverwerkingsfase mogelijk concurrerend is.
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Tobi, Elmar W. ; Slieker, Roderick C. ; Luijk, René ; Dekkers, Koen F. ; Stein, Aryeh D. ; Xu, Kate M. ; Slagboom, P.E. ; Zwet, Erik W. Van; Lumey, L.H. ; Heijmans, Bastiaan T. ; T'Hoen, Peter A. ; Pool, René ; Greevenbroek, Marleen M. Van; Stehouwer, Coen D. ; Kallen, Carla J. Van Der; Schalkwijk, Casper G. ; Wijmenga, Cisca ; Zhernakova, Sasha ; Tigchelaar, Ettje F. ; Beekman, Marian ; Deelen, Joris ; Heemst, Diana Van; Veldink, Jan H. ; Berg, Leonard H. Van Den; Duijn, Cornelia M. Van; Hofman, Albert ; Uitterlinden, André G. ; Jhamai, P.M. ; Verbiest, Michael ; Verkerk, Marijn ; Breggen, Ruud Van Der; Rooij, Jeroen Van; Lakenberg, Nico ; Mei, Hailiang ; Bot, Jan ; Zhernakova, Dasha V. ; Hof, Peter Van 't; Deelen, Patrick ; Nooren, Irene ; Moed, Matthijs ; Vermaat, Martijn ; Jan Bonder, Marc ; Dijk, Freerk Van; Arindrarto, Wibowo ; Kielbasa, Szymon M. ; Swertz, Morris A. ; Isaacs, Aaron ; Franke, Lude - \ 2018
Science Advances 4 (2018)1. - ISSN 2375-2548
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide exploration across 342, 596 cytosine-phosphate-guanine dinucleotides (CpGs) for potential mediators of the association between prenatal famine exposure and adult body mass index (BMI), serum triglycerides (TG), or glucose concentrations, which was followed by formalmediation analysis.DNAm mediated the association of prenatal famine exposure with adult BMI and TG but not with glucose. DNAm at PIM3 (cg09349128), a gene involved in energy metabolism, mediated 13.4% [95% confidence interval (CI), 5 to 28%] of the association between famine exposure and BMI. DNAm at six CpGs, including TXNIP (cg19693031), influencing b cell function, and ABCG1 (cg07397296), affecting lipid metabolism, together mediated 80% (95% CI, 38.5 to 100%) of the association between famine exposure and TG. Analyses restricted to those exposed to famine during early gestation identified additional CpGs mediating the relationship with TG near PFKFB3 (glycolysis) and METTL8 (adipogenesis). DNAm at the CpGs involved was associated with gene expression in an external data set and correlated with DNAm levels in fat depots in additional postmortem data. Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in early life on long-termmetabolic health. The specific mechanism awaits elucidation.
Influence of calcium and phosphate on pH dependency of arsenite and arsenate adsorption to goethite
Deng, Yingxuan ; Li, Yongtao ; Li, Xiaojing ; Sun, Yang ; Ma, Jie ; Lei, Mei ; Weng, Liping - \ 2018
Chemosphere 199 (2018). - ISSN 0045-6535 - p. 617 - 624.
Adsorption - Arsenic - CD-MUSIC - Modeling - Multi-component
In the environment, simultaneous presence of arsenic (As) of different oxidation states is common, which hampers our understanding of As behavior. In the current study, the pH dependency of arsenite (As(III)) and arsenate (As(V)) adsorption to goethite under the influence of calcium (Ca2+) (as a major cation) and phosphate (PO4 3−) (as a major anion) was studied, and the reliability of the CD-MUSIC model prediction was tested. The results show that the presence of the major ions led in general to a weaker and more complicated pH dependency of As adsorption. Calcium promoted As(V) adsorption especially at high pH, which can reverse the direction of the pH dependency. The presence of Ca2+ can even decrease As(III) adsorption when As(V) and/or PO4 3− are present. Phosphate competed strongly with both As(III) and As(V) in their adsorption, especially at intermediate and low pH. In the multi-component system, As(III) adsorbs weaker than As(V) over the environmental relevant pH range, therefore it is often the dominant As species in solution and soluble As(III) concentration generally decreases with increasing pH. In the same pH range, As(V) adsorption shows a complicated pH dependency. Soluble As(V) reaches a minimum around pH 6 at high concentration of major bivalent cations (e.g. Ca2+), whereas soluble As(V) will decrease with pH at low bivalent cation concentrations. The experimental results can be reliably predicted and explained with the CD-MUSIC model. The outcome of this study can provide understanding needed in the risk assessment and remediation of As contaminated soils and water.
Exploring urban metabolism—Towards an interdisciplinary perspective
Dijst, M. ; Worrell, E. ; L., Böcker ; P., Brunner ; Davoudi, S. ; Geertman, S. ; Harmsen, R. ; Helbich, M. ; Holtslag, A.A.M. ; Kwan, Mei-Po ; Lenz, B. ; Lyons, G. ; Mokhtarian, P.L. ; Newman, P. ; Perrels, A. ; Ribeiro, A.P. ; Rosales Carreón, J. ; Thomson, G. ; Urge-Vorsatz, D. ; Zeyringer, M. - \ 2018
Resources, Conservation and Recycling 132 (2018). - ISSN 0921-3449 - p. 190 - 203.
The discussion on urban metabolism has been long dominated by natural scientists focussing on natural forces shaping the energy and material flows in urban systems. However, in the anthropocene human forces such as industrialization and urbanization are mobilizing people, goods and information at an increasing pace and as such have a large impact on urban energy and material flows. In this white paper, we develop a combined natural and social science perspective on urban metabolism. More specifically, innovative conceptual and methodological interdisciplinary approaches are identified and discussed to enhance the understanding of the forces that shape urban metabolism, and how these forces affect urban living and the environment. A challenging research agenda on urban metabolism is also presented.
The significance of meaning. Why IPBES needs the social sciences and humanities
Jetzkowitz, Jens ; Koppen, C.S.A. van; Lidskog, Rolf ; Ott, Konrad ; Voget-Kleschin, Lieske ; Wong, Catherine Mei Ling - \ 2018
Innovation: The European Journal of Social Science Research 31 (2018)sup1. - ISSN 1351-1610 - p. S38 - S60.
biodiversity - ethics - foundations of biodiversity research - IPBES - methodology - science–policy interface - social sciences

The term “biodiversity” is often used to describe phenomena of nature, which can be studied without a reference to the socially constructed, evaluative, or indeed normative contexts. In our paper, we challenge this conception by focusing particularly on methodological aspects of biodiversity research. We thereby engage with the idea of interdisciplinary biodiversity research as a scientific approach directed at the recognition and management of contemporary society in its ecological embedding. By doing this, we explore how research on and assessments of biodiversity can be enhanced if meaning, aspiration, desires, and related aspects of agency are methodically taken into account. In six sections, we substantiate our claim that the discourse on biodiversity (including the IPBES (Intergovernmental science-policy Platform on Biodiversity and Ecosystem Services) debate) is incomplete without contributions from the social sciences and humanities. In the introduction, a brief overview of biodiversity’s conceptual history is provided showing that “biodiversity” is a lexical invention intended to create a strong political momentum. However, that does not impede its usability as a research concept. Section 2 examines the origins of the Convention on Biological Diversity (CBD) by way of sociological discourse analysis. Subsequently, it proposes a matrix as a means to structure the ambiguities and tensions inherent in the CBD. The matrix reemphasizes our main thesis regarding the need to bring social and ethical expertise to the biodiversity discourse. In Section 3, we offer a brief sketch of the different methods of the natural and social sciences as well as ethics. This lays the groundwork for our Section 4, which explains and illustrates what social sciences and ethics can contribute to biodiversity research. Section 5 turns from research to politics and argues that biodiversity governance necessitates deliberative discourses in which participation of lay people plays an important role. Section 6 provides our conclusions.

Severe hypovitaminosis D in active tuberculosis patients and its predictors
Wang, Qiuzhen ; Liu, Yufeng ; Ma, Yan ; Han, Lei ; Dou, Mei ; Zou, Yue ; Sun, Limei ; Tian, Hong ; Li, Tongxia ; Jiang, Guofeng ; Du, Baoli ; Kou, Tingyan ; Song, Jiaqi ; Kok, Frans J. ; Schouten, Evert G. - \ 2018
Clinical Nutrition 37 (2018)3. - ISSN 0261-5614 - p. 1034 - 1040.
Diabetes - Fish consumption - Outdoor activity - Serum 25(OH)D - Severe vitamin D deficiency - Tuberculosis

Background & aims: Tuberculosis (TB) patients have a significant vitamin D deficiency (VDD) endemic, which may be closely related to the onset and progress of the disease. The comorbidity of diabetes (DM) and TB has posed an increasing challenge in recent years. However, the influence of DM on TB and the possible mechanism are still uncertain. We carried out this study to identify the nutritional status of vitamin D (VD) in TB patients in a northern city in China (latitude 36° N) and investigate the possible predictors of severe vitamin D deficiency (SVDD). Methods: A cross-sectional study including 461 active TB patients (192 with and 269 without DM) were randomly selected from Qingdao Chest Hospital from June 2015 to August 2016. We measured serum 25 hydroxyvitamin D [25(OH)D], and investigated the association between sociodemographic, dietary intake, DM, body mass index (BMI), severity of initial TB signs and symptoms (TB score) and VD status. Multivariate logistic regression analysis was used to define the possible predictors of SVDD. Results: The median serum 25(OH)D concentration was 8.50 ng/mL. Of the 461 TB patients included, 383 (83.1%) had VDD [25(OH)D < 20 ng/mL], and 217 (47.1%) had SVDD [25(OH)D < 8 ng/mL]. The variables associated with serum 25(OH)D concentrations were DM, outdoor activity level, TB score and BMI (p < 0.05). Patients with severe TB score had nearly 5 fold higher risk of having SVDD compared with those in mild subgroup [OR (95% CI) = 4.919 (2.644-9.150), p < 0.001]. Low outdoor activity level also increased the odds of SVDD, while DM and high fish consumption showed protect effects. Conclusions: Severe hypovitaminosis D is prevalent in active TB patients, and the main predictors of SVDD were severe TB score, low outdoor activity, inadequate fish consumption. Lowered serum 25(OH)D may be associated with increased risk of TB in DM.

Dure verliezen door bewaarrot verminderen
Wenneker, M. - \ 2017
Fruitmasters Magazine (2017)mei. - p. 22 - 23.
Verslag 20th Symposium on Housing and Fiseases of Rabbits, Furprovinding animals and Pet animals
Rommers, J.M. - \ 2017
Konijnenwijzer 35 (2017). - p. 25 - 27.
evaluatie - groepshuisvesting - vleeskonijnen - parkhuisvesting - werkbaarheid - parksystemen
Op 17 en 18 mei jl. werd in Celle (Duitsland) het Symposium on Housing
and Diseases of Rabbits, Furproviding animals and Pet animals
gehouden. Dit symposium wordt eenmaal per twee jaar georganiseerd
door Duitsland. Er waren circa 60 deelnemers uit 12 verschillende
landen, waaronder Nederland, België, Duitsland, Zwitserland, Hongarije,
Polen en Slovenië. Het programma bestond uit vijf sessies, te weten: huisvesting (8 presentaties), gedrag (2 presentaties), voeding (4 presentaties), fokkerij (2 presentaties) en ziekte en preventie (2 presentaties). Daarnaast waren er posters, die in een postersessie werden toegelicht. De meeste presentaties handelden over commercieel gehouden konijnen, enkele waren gewijd aan konijnen als huisdier.
The rumen microbiome : An underexplored resource for novel antimicrobial discovery
Oyama, Linda B. ; Girdwood, Susan E. ; Cookson, Alan R. ; Fernandez-Fuentes, Narcis ; Privé, Florence ; Vallin, Hannah E. ; Wilkinson, Toby J. ; Golyshin, Peter N. ; Golyshina, Olga V. ; Mikut, Ralf ; Hilpert, Kai ; Richards, Jennifer ; Wootton, Mandy ; Edwards, Joan E. ; Maresca, Marc ; Perrier, Josette ; Lundy, Fionnuala T. ; Luo, Yu ; Zhou, Mei ; Hess, Matthias ; Mantovani, Hilario C. ; Creevey, Christopher J. ; Huws, Sharon A. - \ 2017
npj Biofilms and Microbiomes 3 (2017)1. - ISSN 2055-5008
Antimicrobial peptides (AMPs) are promising drug candidates to target multi-drug resistant bacteria. The rumen microbiome presents an underexplored resource for the discovery of novel microbial enzymes and metabolites, including AMPs. Using functional screening and computational approaches, we identified 181 potentially novel AMPs from a rumen bacterial metagenome. Here, we show that three of the selected AMPs (Lynronne-1, Lynronne-2 and Lynronne-3) were effective against numerous bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). No decrease in MRSA susceptibility was observed after 25 days of sub-lethal exposure to these AMPs. The AMPs bound preferentially to bacterial membrane lipids and induced membrane permeability leading to cytoplasmic leakage. Topical administration of Lynronne-1 (10% w/v) to a mouse model of MRSA wound infection elicited a significant reduction in bacterial counts, which was comparable to treatment with 2% mupirocin ointment. Our findings indicate that the rumen microbiome may provide viable alternative antimicrobials for future therapeutic application.
Eindrapportage monitoringsproject Meer schermen in Gerbera zonder kwaliteitsproblemen : Seizoen '16-'17
Vanthoor, B.H.E. ; Tsafaras, I. ; Persoon, Stefan ; Mei, Martin van der - \ 2017
Wageningen University & Research, BU Glastuinbouw - 17 p.
Gerbera HNT rapportage 2016-2017
Towards radical transport innovation and urban quality of life, Another perspective on transport
Aalbers, Carmen - \ 2017
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