Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Low carbon heating and cooling by combining various technologies with Aquifer Thermal Energy Storage
Pellegrini, M. ; Bloemendal, M. ; Hoekstra, N. ; Spaak, G. ; Andreu Gallego, A. ; Rodriguez Comins, J. ; Grotenhuis, T. ; Picone, S. ; Murrell, A.J. ; Steeman, H.J. - \ 2019
Science of the Total Environment 665 (2019). - ISSN 0048-9697 - p. 1 - 10.
Aquifer Thermal Energy Storage - Geothermal energy - Heating and cooling - Photovoltaic-thermal module - Pilot plant - Remediation - Technological innovation - Water scarcity

A transition to a low carbon energy system is needed to respond to global challenge of climate change mitigation. Aquifer Thermal Energy Storage (ATES) is a technology with worldwide potential to provide sustainable space heating and cooling by (seasonal) storage and recovery of heat in the subsurface. However, adoption of ATES varies strongly across Europe, because of both technical as well as organizational barriers, e.g. differences in climatic and subsurface conditions and legislation respectively. After identification of all these barriers in a Climate-KIC research project, six ATES pilot systems have been installed in five different EU-countries aiming to show how such barriers can be overcome. This paper presents the results of the barrier analysis and of the pilot plants. The barriers are categorized in general barriers, and barriers for mature and immature markets. Two pilots show how ATES can be successfully used to re-develop contaminated sites by combining ATES with soil remediation. Two other pilots show the added value of ATES because its storage capacity enables the utilization of solar heat in combination with solar power production. Finally, two pilots are realized in countries with legal barriers where ATES systems have not previously been applied at all.

Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
Ulaszewska, Marynka M. ; Weinert, Christoph H. ; Trimigno, Alessia ; Portmann, Reto ; Andres Lacueva, Cristina ; Badertscher, René ; Brennan, Lorraine ; Brunius, Carl ; Bub, Achim ; Capozzi, Francesco ; Cialiè Rosso, Marta ; Cordero, Chiara E. ; Daniel, Hannelore ; Durand, Stéphanie ; Egert, Bjoern ; Ferrario, Paola G. ; Feskens, Edith J.M. ; Franceschi, Pietro ; Garcia-Aloy, Mar ; Giacomoni, Franck ; Giesbertz, Pieter ; González-Domínguez, Raúl ; Hanhineva, Kati ; Hemeryck, Lieselot Y. ; Kopka, Joachim ; Kulling, Sabine E. ; Llorach, Rafael ; Manach, Claudine ; Mattivi, Fulvio ; Migné, Carole ; Münger, Linda H. ; Ott, Beate ; Picone, Gianfranco ; Pimentel, Grégory ; Pujos-Guillot, Estelle ; Riccadonna, Samantha ; Rist, Manuela J. ; Rombouts, Caroline ; Rubert, Josep ; Skurk, Thomas ; Sri Harsha, Pedapati S.C. ; Meulebroek, Lieven Van; Vanhaecke, Lynn ; Vázquez-Fresno, Rosa ; Wishart, David ; Vergères, Guy - \ 2018
Molecular Nutrition & Food Research 63 (2018)1. - ISSN 1613-4125
GC–MS - LC–MS - metabolomics - NMR - nutrition
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful “tips and tricks” along the analytical workflow.
Lifelong calorie restriction and markers of colonic health in aging mice
Kok, D.E.G. ; Rusli, F. ; Lugt, B.M. van der; Lute, C. ; Laghi, Luca ; Salvioli, Stefano ; Picone, Gianfranco ; Franceschi, Claudio ; Smidt, H. ; Vervoort, J.J.M. ; Kampman, E. ; Müller, Michael ; Steegenga, W.T. - \ 2018
Mus musculus - GSE100701 - PRJNA392687
Diminishment of colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an efficient strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here we report the effects of lifelong CR on markers of colonic health in aging mice. We show that 30% energy reduction, as compared to a control (C) and moderate-fat (MF) diet, is associated with attenuated immune-related gene expression and lower levels of bile acids in the colon. Pronounced shifts in microbiota composition, together with lowered plasma levels of interleukin 6, in mice exposed to CR are in line with these findings. Furthermore, expression of genes involved in lipid metabolism was higher upon CR as compared to C and MF, pointing towards efficient regulation of energy metabolism. Switching from CR to an ad libitum MF diet at old age revealed remarkable phenotypic plasticity, although expression of a small subset of genes remained CR-associated. This research demonstrates that CR beneficially affects markers of colonic health in aging mice and as such may attenuate the progressive age-related decline in health.
Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice
Kok, Dieuwertje E.G. ; Rusli, Fenni ; Lugt, Benthe van der; Lute, Carolien ; Laghi, Luca ; Salvioli, Stefano ; Picone, Gianfranco ; Franceschi, Claudio ; Smidt, Hauke ; Vervoort, Jacques ; Kampman, Ellen ; Müller, Michael ; Steegenga, Wilma T. - \ 2018
Journal of Nutritional Biochemistry 56 (2018). - ISSN 0955-2863 - p. 152 - 164.
Aging - Calorie restriction - Colonic health - Gene expression - Gut microbiota - Metabolites
Diminished colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an effective strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here, we report the effects of lifelong CR on indicators of colonic health in aging C57Bl/6J mice. Compared to an ad libitum control and moderate-fat diet, 30% energy reduction was associated with attenuated immune- and inflammation-related gene expression in the colon. Furthermore, expression of genes involved in lipid metabolism was higher upon CR, which may point towards efficient regulation of energy metabolism. The relative abundance of bacteria considered beneficial to colonic health, such as Bifidobacterium and Lactobacillus, increased in the mice exposed to CR for 28 months as compared to the other diet groups. We found lower plasma levels of interleukin-6 and lower levels of various metabolites, among which are bile acids, in the colonic luminal content of CR-exposed mice as compared to the other diet groups. Switching from CR to an ad libitum moderate-fat diet at old age (24 months) revealed remarkable phenotypic plasticity in terms of gene expression, microbiota composition and metabolite levels, although expression of a subset of genes remained CR-associated. This study demonstrated in a comprehensive way that CR affects indicators of colonic health in aging mice. Our findings provide unique leads for further studies that need to address optimal and feasible strategies for prolonged energy deprivation, which may contribute to healthy aging.
Toluene biodegradation rates in unsaturated soil systems versus liquid batches and their relevance to field conditions
Picone, S. ; Grotenhuis, J.T.C. ; Gaans, P. van; Valstar, J. ; Langenhoff, A.A.M. ; Rijnaarts, H. - \ 2013
Applied Microbiology and Biotechnology 97 (2013)17. - ISSN 0175-7598 - p. 7887 - 7898.
vapor intrusion - vadose-zone - aerobic biodegradation - petroleum-hydrocarbons - numerical-model - carbon-dioxide - water-content - new-jersey - kinetics - benzene
Contaminant biodegradation in unsaturated soils may reduce the risks of vapor intrusion. However, the reported rates show large variability and are often derived from slurry experiments that are not representative of unsaturated conditions. Here, different laboratory setups are used to derive the biodegradation capacity of an unsaturated soil layer through which gaseous toluene migrates from the water table upwards. Experiments in static unsaturated soil microcosms at 6-30 % water-filled porosity (WFP) and unsaturated soil columns at 9, 14, and 27 % WFP were compared with liquid batches containing the same culture of Alicycliphilus denitrificans. The biodegradation rates for the liquid batches were orders of magnitude lower than for the other setups. Hence, liquid batches do not necessarily reflect optimal conditions for bacteria; either oxygen or toluene mass transfer at the cell scale or the absence of soil-water-air interfaces seemed to be limiting bacterial activity. For the column setup, the rates were limited by mass supply. The microcosm results could be described by apparent first-order biodegradation constants that increased with WFP or through a numerical model that included biodegradation as a first-order process taking place in the liquid phase only. The model liquid phase first-order rates varied between 6.25 and 20 h(-1) and were not related to the water content. Substrate availability was the primary factor limiting bioactivity, with evidence for physiological stress at the lowest water-filled porosity. The presented approach is useful to derive liquid phase biodegradation rates from experimental data and to include biodegradation in vapor intrusion models.
Sensitivity analysis on parameters and processes affecting vapor intrusion risk
Picone, S. ; Valstar, J.R. ; Gaans, P. van; Grotenhuis, J.T.C. ; Rijnaarts, H.H.M. - \ 2012
Environmental Toxicology and Chemistry 31 (2012)5. - ISSN 0730-7268 - p. 1042 - 1052.
unsaturated porous-media - capillary-fringe - indoor-air - organic-compounds - gas-transport - vadose zone - soil - groundwater - biodegradation - buildings
A one-dimensional numerical model was developed and used to identify the key processes controlling vapor intrusion risks by means of a sensitivity analysis. The model simulates the fate of a dissolved volatile organic compound present below the ventilated crawl space of a house. In contrast to the vast majority of previous studies, this model accounts for vertical variation of soil water saturation and includes aerobic biodegradation. The attenuation factor (ratio between concentration in the crawl space and source concentration) and the characteristic time to approach maximum concentrations were calculated and compared for a variety of scenarios. These concepts allow an understanding of controlling mechanisms and aid in the identification of critical parameters to be collected for field situations. The relative distance of the source to the nearest gas-filled pores of the unsaturated zone is the most critical parameter because diffusive contaminant transport is significantly slower in water-filled pores than in gas-filled pores. Therefore, attenuation factors decrease and characteristic times increase with increasing relative distance of the contaminant dissolved source to the nearest gas diffusion front. Aerobic biodegradation may decrease the attenuation factor by up to three orders of magnitude. Moreover, the occurrence of water table oscillations is of importance. Dynamic processes leading to a retreating water table increase the attenuation factor by two orders of magnitude because of the enhanced gas phase diffusion
Transport and biodegradation of volatile organic compounds : influence on vapor intrusion into buildings
Picone, S. - \ 2012
Wageningen University. Promotor(en): Huub Rijnaarts, co-promotor(en): Tim Grotenhuis; P.F.M. van Gaans. - S.l. : s.n. - ISBN 9789461732767 - 149
vluchtige verbindingen - organische verbindingen - biodegradatie - biochemisch transport - gebouwen - grondwaterverontreiniging - binnenklimaat - volatile compounds - organic compounds - biodegradation - biochemical transport - buildings - groundwater pollution - indoor climate

Vapor intrusion occurs when volatile subsurface contaminants, migrating from the saturated zone through the unsaturated zone, accumulate in buildings. It is often the most relevant pathway for human health risks at contaminated sites, especially in urban areas; yet its assessment is controversial. Field assessment of vapor intrusion risk is complicated by two interrelated main factors that are controlled by the contaminant’s properties: transport processes in the unsaturated zone and biodegradation in the unsaturated zone. Commonly available vapor intrusion models either overlook significant properties at the field scale or, conversely, are too complex to be applicable at this scale. Specifically, moisture variation, liquid diffusion, dynamic processes such as water table variations, and biodegradation are not adequately accounted for. As a result, the soil gas and indoor air concentrations predicted by existing models frequently overestimate measured concentrations by several orders of magnitude.
This thesis addressed transport and biodegradation processes of volatile organic compounds, focusing on aerobic unsaturated zones. The main aims were to i) characterize significant transport processes influencing vapor intrusion and ii) quantify and mechanistically describe biodegradation in unsaturated soils. Field experience, numerical modeling and laboratory experiments with toluene and vinyl chloride as reference compounds were combined to separate out the relevant processes influencing vapor intrusion.
The main conclusions from this thesis indicate that soil moisture variations and aerobic biodegradation are crucial aspects to be jointly considered for the assessment of vapor intrusion. These may contribute to a significant reduction in the risk associated with dissolved volatile organic contaminants. Specific and relevant implications for modeling and monitoring vapor intrusion can be derived. With respect to vapor intrusion modeling, when including unsaturated zone biodegradation, the use of liquid phase biodegradation rates as derived from liquid mixed batches may underestimate by several orders of magnitude the liquid degradation rates in the unsaturated system. Therefore, biodegradation rates derived from unsaturated system appear more appropriate. With respect to monitoring, vertical soil moisture variations and contaminant/oxygen concentration profiles need to be measured in the field, in order to account for the above processes.

On line monitoring of risks from vertical transport of volatile contaminants: feasibility study
Picone, S. ; Grotenhuis, J.T.C. ; Gaans, P. van; Rijnaarts, H.H.M. - \ 2008
In: Proceedings 10th International UFZ Deltares/TNO Conference on Soil-Water Systems, Milano, Italy, 3 - 6 June, 2008. - Milano : UFZ Deltares/TNO - ISBN 9783000245985 - p. D253 - D257.
Monitoring of Risks deriving from Chlorinated Hydrocarbons
Picone, S. ; Grotenhuis, J.T.C. ; Gaans, P. van; Valstar, J.R. ; Gargini, A. ; Rijnaarts, H.H.M. - \ 2007
Integrated Monitoring for Risk Assessment at Chlorinated Solvents Contaminated Sites
Picone, S. ; Grotenhuis, J.T.C. ; Rijnaarts, H.H.M. ; Meer, J. ; Gargini, A. - \ 2007
Quantification of (Human Health) Risks from Chlorinated Hydrocarbons
Picone, Sara - \ 2007
Risk assessment and Risk Mitigation Technologies for Chlorinated Solvents Contaminated Sites
Picone, Sara - \ 2007
Isotopic Fingerprinting and Indoor Gas Monitoring in chlorinated ethenes contaminated groundwater: Case Studies in the Municipality of Ferrara, Italy
Picone, Sara - \ 2007
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