Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Protein engineering of lantibiotics.
Kuipers, O.P. ; Bierbaum, G. ; Ottenwälder, G. ; Dodd, H.M. ; Horn, N. ; Metzger, J. ; Kupke, T. ; Gnau, V. ; Bongers, R. ; Boogaard, P. van den; Kosters, H. ; Rollema, H.S. ; Vos, W.M. de; Siezen, R.J. ; Jung, G. ; Götz, F. ; Sahl, H.G. ; Gasson, M.J. - \ 1996
Antonie van Leeuwenhoek: : Nederlandsch tijdschrift voor hygiëne, microbiologie en serologie 69 (1996). - ISSN 0003-6072 - p. 161 - 169.
Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering.
Rollema, H.S. ; Kuipers, O.P. ; Both, P. ; Vos, W.M. de; Siezen, R.J. - \ 1995
Applied and Environmental Microbiology 61 (1995). - ISSN 0099-2240 - p. 2873 - 2878.
Protein engineering and biosynthesis of nisin and regulation of transcription of the structural nisA gene.
Kuipers, O.P. ; Rollema, H.S. ; Beerthuyzen, M.M. ; Siezen, R.J. ; Vos, W.M. de - \ 1995
International Dairy Journal 5 (1995). - ISSN 0958-6946 - p. 785 - 795.
Lactococcal expression systems for protein engineering of nisin.
Kuipers, O.P. ; Rollema, H.S. ; Siezen, R.J. ; Vos, W.M. de - \ 1995
Developments in biological standardization 85 (1995). - ISSN 0301-5149 - p. 605 - 614.
Biosynthesis and engineering of the antimicrobial peptide nisin of Lactocococus lactis.
Siezen, R.J. ; Rollema, H.S. ; Beerthuyzen, M.M. ; Meer, J.R. van der; Vos, W.M. de; Kuipers, O.P. - \ 1995
In: Protein engineering and complementary technologies / Geisow, M.J., Epton, R., - p. 74 - 77.
Homology modelling of the Lactococcus lactis leader peptidase NisP and its interaction with the precursor of the lantibiotic nisin.
Siezen, R.J. ; Rollema, H.S. ; Kuipers, O.P. ; Vos, W.M. de - \ 1995
Protein Engineering 8 (1995). - ISSN 0269-2139 - p. 117 - 125.
Mode of action of nisin Z against Listeria monocytogenes Scott A grown at high and low temperatures.
Abee, T. ; Rombouts, F.M. ; Hugenholtz, J. ; Guihard, G. ; Letellier, L. - \ 1994
Applied and Environmental Microbiology 60 (1994)6. - ISSN 0099-2240 - p. 1962 - 1968.
Nisin Z, a natural nisin variant, was recently isolated from Lactococcus lactis subspecies lactis NIZO 22186. The gene for this lantibiotic, designated nisZ, has been cloned, and its nucleotide sequence was found to be identical to that of the precursor nisin gene with the exception of a single mutation resulting in the substitution of Asn-27 for His-27 in the mature polypeptide (J. W. M. Mulders, I. J. Boerrigter, H. S. Rollema, R. J. Siezen, and W. M. de Vos, Eur. J. Biochem. 201:581-584, 1991). A K electrode was used to investigate the effect of various environmental parameters on the action of nisin Z against Listeria monocytogenes. Addition of nisin Z resulted in immediate loss of cell K , depolarization of the cytoplasmic membrane, inhibition of respiratory activity, and hydrolysis and partial efflux of cellular ATP. The action of nisin Z was optimal at pH 6.0 and was significantly reduced by di- and trivalent cations. The lanthanide gadolinium (Gd3 ) was an efficient inhibitor and prevented nisin Z activity completely at a concentration of 0.2 mM. Nisin Z-induced loss of cell K was reduced at low temperatures, presumably as a result of the increased ordering of the lipid hydrocarbon chains in the cytoplasmic membrane. In cells grown at 30°C, the action of nisin Z was prevented below 7°C, whereas in cells grown at 4°C nisin Z was able to induce K leakage at this low temperature.
Biosynthesis and protein engineering of nisin.
Kuipers, O.P. ; Rollema, H.S. ; Beerthuyzen, M.M. ; Meer, J.R. van der; Vos, W.M. de; Siezen, R.J. - \ 1994
In: Proc. 6th Eur. Congr. Biotechnology, L. Alberghina et al. (eds.). Elsevier Sci. Publ - p. 441 - 446.
Analysis of the nisin leader peptide sequence on nisin biosynthesis in Lactococcus lactis by site directed mutagenesis.
Meer, J.R. van der; Rollema, H.S. ; Siezen, R.J. ; Kuipers, O.P. ; Vos, W.M. de - \ 1994
Journal of Biological Chemistry 60 (1994). - ISSN 0021-9258 - p. 587 - 593.
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