Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Antibacterial prenylated stilbenoids from peanut (Arachis hypogaea)
Bruijn, Wouter J.C. de; Araya-Cloutier, Carla ; Bijlsma, Judith ; Swart, Anne de; Sanders, Mark G. ; Waard, Pieter de; Gruppen, Harry ; Vincken, Jean Paul - \ 2018
Phytochemistry letters 28 (2018). - ISSN 1874-3900 - p. 13 - 18.
Antimicrobial - Leguminosae - Natural product - Prenylation - Secondary metabolite - Stilbene

Stilbenoids are a class of secondary metabolites with a stilbene backbone that can be produced by peanut (Arachis hypogaea) as defence metabolites. Six monomeric prenylated stilbenoids, including the compound arachidin-6 (4), were isolated from extracts of fungus-elicited peanuts (Arachis hypogaea) using preparative liquid chromatography. Their structures were confirmed by MSn, HRMS and NMR spectroscopy and their antibacterial activity was evaluated against methicillin-resistant Staphylococcus aureus (MRSA). Similarly to other phenolic compounds, prenylated derivatives of stilbenoids were more active than their non-prenylated precursors piceatannol, resveratrol, and pinosylvin. Chiricanine A (6), a chain-prenylated pinosylvin derivative, was the most potent compound tested, with a minimum inhibitory concentration (MIC) of 12.5 μg mL−1. Arachidin-6 (4), a ring-prenylated piceatannol derivative, had moderate potency (MIC 50–75 μg mL−1). In conclusion, prenylated stilbenoids represent a group of potential natural antibacterials which show promising activity against MRSA.

Author Correction: Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries
Munk, Patrick ; Knudsen, Berith Elkær ; Lukjancenko, Oksana ; Duarte, Ana Sofia Ribeiro ; Gompel, Liese Van; Luiken, Roosmarijn E.C. ; Smit, Lidwien A.M. ; Schmitt, Heike ; Garcia, Alejandro Dorado ; Hansen, Rasmus Borup ; Petersen, Thomas Nordahl ; Bossers, Alex ; Ruppé, Etienne ; Lund, Ole ; Hald, Tine ; Pamp, Sünje Johanna ; Vigre, Håkan ; Heederik, Dick ; Wagenaar, Jaap A. ; Mevius, Dik ; Aarestrup, Frank M. ; Graveland, Haitske ; Essen, Alieda van; Gonzalez-Zorn, Bruno ; Moyano, Gabriel ; Sanders, Pascal ; Chauvin, Claire ; David, Julie ; Battisti, Antonio ; Caprioli, Andrea ; Dewulf, Jeroen ; Blaha, Thomas ; Wadepohl, Katharina ; Brandt, Maximiliane ; Wasyl, Dariusz ; Skarzyńska, Magdalena ; Zajac, Magdalena ; Daskalov, Hristo ; Saatkamp, Helmut W. ; Stärk, Katharina D.C. - \ 2018
Nature Microbiology 3 (2018). - ISSN 2058-5276 - p. 1186 - 1186.

In the version of this Article originally published, the surname of author Oksana Lukjancenko was spelt incorrectly as ‘Lukjacenko’. This has now been corrected.

Balans van de Leefomgeving 2018 : Nederland duurzaam vernieuwen
Egmond, Petra van; Elzenga, Hans ; Buitelaar, Edwin ; Eerdt, Martha van; Eskinasi, Martijn ; Franken, Ron ; Gaalen, Frank van; Hanemaaijer, Aldert ; Hilbers, Hans ; Hollander, Guus de; Nijland, Hans ; Ritsema van Eck, Jan ; Ros, Jan ; Schilder, Frans ; Spoon, Martijn ; Uitbeijerse, Gabrielle ; Wouden, Ries van der; Vonk, Marijke ; Vugteveen, Pim ; Goossen, Martijn ; Blom, Wim ; Bredenoord, Hendrien ; Brink, Thelma van den; Evers, David ; Doren, Didi van; Grinsven, Hans van; Hinsberg, Arjen van; Muilwijk, Hanneke ; Oorschot, Mark van; Peeters, Jeroen ; Puijenbroek, Peter van; Raspe, Otto ; Rijn, Frank van; Schijndel, Marian van; Sluis, Sietske van der; Sorel, Niels ; Timmerhuis, Jacqueline ; Verwest, Femke ; Westhoek, Henk ; Sanders, Marlies ; Dirkx, Joep - \ 2018
Den Haag : Planbureau voor de Leefomgeving - 284
Developing a role for Rhizopus oryzae in the biobased economy by aiming at ethanol and cyanophycin coproduction
Meussen, Bas Johannes - \ 2018
University. Promotor(en): Johan Sanders, co-promotor(en): Ruud Weusthuis. - Wageningen : Wageningen University - ISBN 9789463434843 - 169
Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries
Munk, Patrick ; Knudsen, Berith Elkær ; Lukjacenko, Oksana ; Duarte, Ana Sofia Ribeiro ; Gompel, Liese Van; Luiken, Roosmarijn E.C. ; Smit, Lidwien A.M. ; Schmitt, Heike ; Garcia, Alejandro Dorado ; Hansen, Rasmus Borup ; Petersen, Thomas Nordahl ; Bossers, Alex ; Ruppé, Etienne ; Graveland, Haitske ; Essen, Alieda van; Gonzalez-Zorn, Bruno ; Moyano, Gabriel ; Sanders, Pascal ; Chauvin, Claire ; David, Julie ; Battisti, Antonio ; Caprioli, Andrea ; Dewulf, Jeroen ; Blaha, Thomas ; Wadepohl, Katharina ; Brandt, Maximiliane ; Wasyl, Dariusz ; Skarzyńska, Magdalena ; Zajac, Magdalena ; Daskalov, Hristo ; Saatkamp, Helmut W. ; Stärk, Katharina D.C. ; Lund, Ole ; Hald, Tine ; Pamp, Sünje Johanna ; Vigre, Håkan ; Heederik, Dick ; Wagenaar, Jaap A. ; Mevius, Dik ; Aarestrup, Frank M. - \ 2018
Nature Microbiology 3 (2018)8. - ISSN 2058-5276 - p. 898 - 908.

Antimicrobial resistance (AMR) in bacteria and associated human morbidity and mortality is increasing. The use of antimicrobials in livestock selects for AMR that can subsequently be transferred to humans. This flow of AMR between reservoirs demands surveillance in livestock and in humans. We quantified and characterized the acquired resistance gene pools (resistomes) of 181 pig and 178 poultry farms from nine European countries, sequencing more than 5,000 Gb of DNA using shotgun metagenomics. We quantified acquired AMR using the ResFinder database and a second database constructed for this study, consisting of AMR genes identified through screening environmental DNA. The pig and poultry resistomes were very different in abundance and composition. There was a significant country effect on the resistomes, more so in pigs than in poultry. We found higher AMR loads in pigs, whereas poultry resistomes were more diverse. We detected several recently described, critical AMR genes, including mcr-1 and optrA, the abundance of which differed both between host species and between countries. We found that the total acquired AMR level was associated with the overall country-specific antimicrobial usage in livestock and that countries with comparable usage patterns had similar resistomes. However, functionally determined AMR genes were not associated with total drug use.

Modelling the solubility of the 20 proteinogenic amino acids with experimentally derived saturation data
Bowden, Nathan A. - \ 2018
University. Promotor(en): Johan Sanders, co-promotor(en): Marieke Bruins. - Wageningen : Wageningen University - ISBN 9789463438612 - 261
Zeapyranolactone − A novel strigolactone from maize
Charnikhova, Tatsiana V. ; Gaus, Katharina ; Lumbroso, Alexandre ; Sanders, Mark ; Vincken, Jean Paul ; Mesmaeker, Alain De; Ruyter-Spira, Carolien P. ; Screpanti, Claudio ; Bouwmeester, Harro J. - \ 2018
Phytochemistry letters 24 (2018). - ISSN 1874-3900 - p. 172 - 178.
Maize (Zea mays) - NMR - Prep-HPLC–MS - Strigolactones - Zeapyranolactone
The structure of a new strigolactone present in the root exudate and root extract of maize hybrid cv NK Falkone plants was elucidated and characterized as zeapyranolactone: Methyl.(E)-3-((4-methyl-5-oxo-2,5-dihydrofuran-2-yl)oxy)-2-(4,4,5-trimethyl-2-oxo-2,3,4,6,7,7a-hexahydrocyclopenta[b]pyran-7-yl)acrylate. Unlike any other strigolactone published so far, it contains a 4,4-dimethyltetrahydropyran-2-one as A ring. The impact of the elucidation of this structure on the earlier postulated biosynthetic pathway of another maize strigolactone, zealactone, is discussed.
Solubility of the Proteinogenic α-Amino Acids in Water, Ethanol, and Ethanol-Water Mixtures
Bowden, Nathan A. ; Sanders, Johan P.M. ; Bruins, Marieke E. - \ 2018
Journal of Chemical and Engineering Data 63 (2018)3. - ISSN 0021-9568 - p. 488 - 497.
The addition of organic solvents to α-amino acids in aqueous solution could be an effective method in crystallization. We reviewed the available data on the solubility of α-amino acids in water, water-ethanol mixtures, and ethanol at 298.15 K and 0.1 MPa. The solubility of l-alanine, l-proline, l-arginine, l-cysteine, and l-lysine in water and ethanol mixtures and the solubility of l-alanine, l-proline, l-arginine, l-cysteine, l-lysine, l-asparagine, l-glutamine, l-histidine, and l-leucine in pure ethanol systems were measured and are published here for the first time. The impact on the solubility of amino acids that can convert in solution, l-glutamic acid and l-cysteine, was studied. At lower concentrations, only the ninhydrin method and the ultraperfomance liquid chromatography (UPLC) method yield reliable results. In the case of α-amino acids that convert in solution, only the UPLC method was able to discern between the different α-amino acids and yields reliable results. Our results demonstrate that α-amino acids with similar physical structures have similar changes in solubility in mixed water/ethanol mixtures. The solubility of l-tryptophan increased at moderate ethanol concentrations.
Sustainable scenarios for alkaline protein extraction from leafy biomass using green tea residue as a model material
Zhang, Chen ; Slegers, Petronella M. ; Wisse, Jacobus ; Sanders, Johan P.M. ; Bruins, Marieke E. - \ 2018
Biofuels Bioproducts and Biorefining 12 (2018)4. - ISSN 1932-104X - p. 586 - 599.
Biorefinery - Cost - LCA - Micro-algae - Protein extraction - Tea residue
Leaf protein can be extracted cost-efficiently using 0.1 mol dm-3 NaOH, but this process is less sustainable due to the generation of large amounts of sodium salts. KOH or Ca(OH)2 are considered as replacements for NaOH, as these salts can be reused. This work evaluates the economic and environmental sustainability of weak alkaline pectin extraction followed by KOH enhanced protein extraction, and Viscozyme® L-aided pectin extraction followed by Ca(OH)2 enhanced protein extraction. The evaluations are made for green tea residue and are compared to related processes using NaOH. The predicted profits using KOH are comparable to those using NaOH. Environmental sustainability improves for all impact categories in the case of KOH extraction. Further environmental benefits are obtained by substituting conventional K fertilizer with the K-rich salty waste water from the extraction process. The profits of the process using Ca(OH)2 are highly dependent on the extraction yield of the protein product. Protein extraction yields using Ca(OH)2 need to be higher than 70% to be more profitable than the same process with NaOH. The environmental benefits of Ca(OH)2 extraction include the absence of salty waste water and the net production of heat. This is accompanied by increased electricity consumption. Thus, the impact categories of climate change, fossil and water depletion, and particulate matter formation worsen. Photochemical oxidant formations remain the same, while the other impacts improve. This work has shown the potential and bottlenecks of NaOH, KOH and Ca(OH)2 protein extraction on different types of biomass in terms of environmental and economic sustainability.
Acceptance of new sanitation : The role of end-users' pro-environmental personal norms and risk and benefit perceptions
Poortvliet, P.M. ; Sanders, Liese ; Weijma, Jan ; Vries, Jasper R. De - \ 2018
Water Research 131 (2018). - ISSN 0043-1354 - p. 90 - 99.
Decentralized sanitation - New sanitation - Pro-environmental personal norms - Risk perception - Value-belief-norm theory - Wastewater

Current sanitation systems are inherently limited in their ability to address the new challenges for (waste)water management that arise from the rising demand to restore resource cycles. These challenges include removal of micropollutants, water (re)use, and nutrient recovery. New opportunities to address these challenges arise from new sanitation, a system innovation that combines elements of source separation, local treatment and reuse, and less use of water. New sanitation is applied, but not yet widespread, in several residential areas in Europe. Implementation is hindered by the lack of insight into the general public's willingness to engage in new sanitation, and the resulting uncertainty about this among decision makers and other stakeholders in wastewater management. Using value-belief-norm theory as a conceptual lens, this paper addresses the individual motivations (pro-environmental personal norms) and personal drivers (benefits) and barriers (risks) for acceptance of new sanitation by the Dutch general public. The results of an online survey (N = 338) indicated that both pro-environmental personal norms and risk and benefit perceptions predict consumers' willingness to accept new sanitation. More specifically, they showed that consumer acceptance is driven by perceived risks relating to the housing market and the need to change behavior, but also by environmental benefits. Overall, new sanitation was favorably evaluated by respondents: 64% indicated that they would likely use new sanitation if they were owner-occupiers. The results of this explorative study are discussed in light of the development of novel sanitation systems that are sensitive to perceptions of end-users and other key stakeholders.

Modelling the effects of ethanol on the solubility of the proteinogenic amino acids with the NRTL, Gude and Jouyban-Acree models
Bowden, Nathan A. ; Sevillano, David Mendez ; Sanders, Johan P.M. ; Bruins, Marieke E. - \ 2018
Fluid Phase Equilibria 459 (2018). - ISSN 0378-3812 - p. 158 - 169.
Aqueous-solutions - Equilibria - Excess solubility - Organic solvents - Thermodynamics
The addition of organic solvents, such as ethanol, to molecules in solution is an effective process for crystallization and is used in industrial settings (i.e. pharmaceutical production, downstream processing, etc.). In this study, we use solubility data of all proteinogenic α-amino acids in binary ethanol/water systems to model their excess solubility. We use the empirical and regressive models of Gude and NRTL and the predictive Jouyban-Acree model. Based on the results, we hypothesize that amino acids that are spherical and lack a reactive side chain show little or no excess solubility. Being rod-like and/or having a reactive side chain leads to a positive excess solubility in a mixed solvent of ethanol and water. The empirical and regressed models, NRTL and Gude, fit the data well and the predictive Jouyban-Acree model, not originally intended to be used for small molecules, is less accurate but offers insights into the thermodynamic properties of the amino acids.
Sustainable protein technology : an evaluation on the STW Protein programme and an outlook for the future
Voudouris, Panagiotis ; Tamayo Tenorio, Angelica ; Lesschen, Jan Peter ; Kyriakopoulou, Konstantina ; Sanders, Johan P.M. ; Goot, Atze Jan van der; Bruins, Marieke E. - \ 2017
Wageningen : Wageningen Food & Biobased Research (Wageningen Food & Biobased Research report 1786) - ISBN 9789463432368 - 58
In 2013 a new STW research programme was started on sustainable protein recovery. This STW Protein Programme consisted of five sustainable protein technology projects, which aimed at developing innovative methods to extract proteins from plant leaves, microalgae and insects to meet the increasing demand for food proteins for humans and livestock. The aim of the additional STW-project ‘Meer en Beter Eiwit’ was to summarize and evaluate the main results and conclusions of these five projects. Besides, some more recent additional insight on protein extraction was supplemented. Project partners including WUR, knowledge institutes and industry were interviewed to obtain their opinion on the project performed and future research needs. This has led to a vision document that gives direction to future research in the field of protein and technology. The approach of this project was to study the topic from start (biomass) via technology to finish (product). It was further put into a larger perspective, looking at the entire chain. When relevant, additional aspects such a soil quality and global protein demands were included.
Sustainable protein technology : An outlook for further research
Voudouris, Panagiotis ; Tamayo Tenorio, Angelica ; Lesschen, Jan Peter ; Kyriakopoulou, Konstantina ; Sanders, Johan P.M. ; Goot, Atze Jan van der; Bruins, Marieke E. - \ 2017
Wageningen : Wageningen Food & Biobased Research - 6 p.
nutrition - biobased economy - protein
Feiten en cijfers natuur en samenleving : Tussenrapportage WOT-04-010-034.41
Sanders, M.E. ; Langers, F. ; Henkens, R.J.H.G. ; Donders, J.L.M. ; Dam, R.I. van; Mattijssen, T.J.M. ; Broekmeyer, M.E.A. ; Adrichem, M.H.C. van; Wamelink, G.W.W. ; Verboom, J. - \ 2017
Wageningen : Wettelijke Onderzoekstaken Natuur & Milieu (WOt-interne notitie 194)
A communal catalogue reveals Earth's multiscale microbial diversity
Thompson, Luke R. ; Sanders, Jon G. ; Mcdonald, D. ; Fogliano, V. ; Jurburg, S.D. ; Larsen, Peter - \ 2017
Nature 551 (2017)7681. - ISSN 0028-0836 - p. 457 - 463.
Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity.
The European Red List of Terrestrial and Freshwater habitats
Rodwell, J. ; Janssen, J.A.M. ; Garcia Criado, M. ; Gubbay, S. ; Haynes, T. ; Nieto, A. ; Sanders, Natalie - \ 2017
In: The 60th IAVS annual symposium, MA Vegetation patterns in natural and cultural landscapes. - Palermo : Palermo University Press - ISBN 9788899934408
The European Red List of Habitats presents the first comprehensive and systematic assessment of the threat level of all terrestrial and freshwater habitats across Europe. Funded by the European Commission, the project was a collaboration of over 150 experts across the EU28 plus Norway, Iceland, Switzerland and the Balkans. Using a typology based on the EUNIS habitat classification at level 3 (crosswalked to the alliances of the EuroVegChecklist) and a modified version of the IUCN Red List of Ecosystems assessment methodology, it provides information on 228 habitats (233 in EU28+) including habitat definition, images, distribution, trends in quantity and quality over the past 50 years, long-term and future trends, pressures and threats, conservation measures, data sources and supporting literature. Assessment revealed that 36% of the habitats (31% for the EU28+) were in the three top IUCN threat categories of Critically Endangered, Endangered and Vulnerable across Europe as whole. Most generally threatened were mires, grasslands, freshwaters and coastal habitats. Forest, heaths & scrubs and sparsely vegetated habitats were generally less threatened but often still of ongoing concern. Reasons for decline in extent and quality were numerous but most important overall were intensification of agriculture, abandonment, drainage and pollution, invasion of alien plants and animals, urbanisation and associated infrastructure development. This paper will provide details of the assessment methodology and results, outline applications of the work and indicate the online availability of project deliverables: the European Red List of Habitats report and powerpoint; and for every habitat a pdf fact-sheet, images, GIS distribution maps and full territorial data. A parallel Red List assessment has been carried out for 257 European marine habitats in the Baltic, Mediterranean and Black Seas and the North-East Atlantic.
From waste water to chemical building blocks
Bitter, J.H. ; Spekreijse, J. ; Notre, J.E.L. le; Holgueras Ortega, J. ; Scott, E.L. ; Sanders, J.P.M. - \ 2017
- 3 p.
A mof immobilized Hoveda-Grubbs metathesis catalyst for the production of methyl acrylate from waste water
Bitter, J.H. ; Spekreijse, J. ; Notre, J.E.L. le; Holgueras Ortega, J. ; Sanders, J.P.M. ; Scott, E.L. - \ 2017
- 2 p.
Enzymatic halogenation and oxidation using an alcohol oxidase-vanadium chloroperoxidase cascade
But, Andrada ; Noord, Aster Van; Poletto, Francesca ; Sanders, Johan P.M. ; Franssen, Maurice C.R. ; Scott, Elinor L. - \ 2017
Molecular Catalysis 443 (2017). - ISSN 2468-8231 - p. 92 - 100.
The chemo-enzymatic cascade which combines alcohol oxidase from Hansenula polymorpha (AOXHp) with vanadium chloroperoxidase (VCPO), for the production of biobased nitriles from amino acids was investigated. In the first reaction H2O2 (and acetaldehyde) are generated from ethanol and oxygen by AOXHp. H2O2 is subsequently used in the second reaction by VCPO to produce HOBr in situ. HOBr is required for the non-enzymatic oxidative decarboxylation of glutamic acid (Glu) to 3-cyanopropanoic acid (CPA), an intermediate in the production of biobased acrylonitrile. It was found that during the one pot conversion of Glu to CPA by AOXHp-VCPO cascade, AOXHp was deactivated by HOBr. To avoid deactivation, the two enzymes were separated in two fed-batch reactors. The deactivation of AOXHp by HOBr appeared to depend on the substrate: an easily halogenated compound like monochlorodimedone (MCD) was significantly converted in one pot by the cascade reaction of AOXHp and VCPO, while conversion of Glu did not occur under those conditions. Apparently, MCD scavenges HOBr before it can inactivate AOXHp, while Glu reacts slower, leading to detrimental concentrations of HOBr. Enzymatically generated H2O2 was used in a cascade reaction involving halogenation steps to enable the co-production of biobased nitriles and acetaldehyde.
Unusual differences in the reactivity of glutamic and aspartic acid in oxidative decarboxylation reactions
But, Andrada ; Wijst, Evie van der; Notre, Jerome le; Wever, Ron ; Sanders, Johan P.M. ; Bitter, Johannes H. ; Scott, Elinor L. - \ 2017
Green Chemistry 19 (2017)21. - ISSN 1463-9262 - p. 5178 - 5186.

Amino acids are potential substrates to replace fossil feedstocks for the synthesis of nitriles via oxidative decarboxylation using vanadium chloroperoxidase (VCPO), H2O2 and bromide. Here the conversion of glutamic acid (Glu) and aspartic acid (Asp) was investigated. It was observed that these two chemically similar amino acids have strikingly different reactivity. In the presence of catalytic amounts of NaBr (0.1 equiv.), Glu was converted with high selectivity to 3-cyanopropanoic acid. In contrast, under the same reaction conditions Asp showed low conversion and selectivity towards the nitrile, 2-cyanoacetic acid (AspCN). It was shown that only by increasing the amount of NaBr present in the reaction mixture (from 0.1 to 2 equiv.), could the conversion of Asp be increased from 15% to 100% and its selectivity towards AspCN from 45% to 80%. This contradicts the theoretical hypothesis that bromide is recycled during the reaction. NaBr concentration was found to have a major influence on reactivity, independent of ionic strength of the solution. NaBr is involved not only in the formation of the reactive Br+ species by VCPO, but also results in the formation of potential intermediates which influences reactivity. It was concluded that the difference in reactivity between Asp and Glu must be due to subtle differences in inter- and intramolecular interactions between the functionalities of the amino acids.

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