Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Minimum Information about a Biosynthetic Gene cluster
Medema, M.H. ; Kottmann, Renzo ; Yilmaz, Pelin ; Cummings, Matthew ; Biggins, J.B. ; Blin, Kai ; Bruijn, Irene De; Chooi, Yit Heng ; Claesen, Jan ; Coates, R.C. ; Cruz-Morales, Pablo ; Duddela, Srikanth ; Düsterhus, Stephanie ; Edwards, Daniel J. ; Fewer, David P. ; Garg, Neha ; Geiger, Christoph ; Gomez-Escribano, Juan Pablo ; Greule, Anja ; Hadjithomas, Michalis ; Haines, Anthony S. ; Helfrich, Eric J.N. ; Hillwig, Matthew L. ; Ishida, Keishi ; Jones, Adam C. ; Jones, Carla S. ; Jungmann, Katrin ; Kegler, Carsten ; Kim, Hyun Uk ; Kötter, Peter ; Krug, Daniel ; Masschelein, Joleen ; Melnik, Alexey V. ; Mantovani, Simone M. ; Monroe, Emily A. ; Moore, Marcus ; Moss, Nathan ; Nützmann, Hans Wilhelm ; Pan, Guohui ; Pati, Amrita ; Petras, Daniel ; Reen, F.J. ; Rosconi, Federico ; Rui, Zhe ; Tian, Zhenhua ; Tobias, Nicholas J. ; Tsunematsu, Yuta ; Wiemann, Philipp ; Wyckoff, Elizabeth ; Yan, Xiaohui ; Yim, Grace ; Yu, Fengan ; Xie, Yunchang ; Aigle, Bertrand ; Apel, Alexander K. ; Balibar, Carl J. ; Balskus, Emily P. ; Barona-Gómez, Francisco ; Bechthold, Andreas ; Bode, Helge B. ; Borriss, Rainer ; Brady, Sean F. ; Brakhage, Axel A. ; Caffrey, Patrick ; Cheng, Yi Qiang ; Clardy, Jon ; Cox, Russell J. ; Mot, René De; Donadio, Stefano ; Donia, Mohamed S. ; Donk, Wilfred A. Van Der; Dorrestein, Pieter C. ; Doyle, Sean ; Driessen, Arnold J.M. ; Ehling-Schulz, Monika ; Entian, Karl Dieter ; Fischbach, Michael A. ; Gerwick, Lena ; Gerwick, William H. ; Gross, Harald ; Gust, Bertolt ; Hertweck, Christian ; Höfte, Monica ; Jensen, Susan E. ; Ju, Jianhua ; Katz, Leonard ; Kaysser, Leonard ; Klassen, Jonathan L. ; Keller, Nancy P. ; Kormanec, Jan ; Kuipers, Oscar P. ; Kuzuyama, Tomohisa ; Kyrpides, Nikos C. ; Kwon, Hyung Jin ; Lautru, Sylvie ; Lavigne, Rob ; Lee, Chia Y. ; Linquan, Bai ; Liu, Xinyu ; Liu, Wen ; Luzhetskyy, Andriy ; Mahmud, Taifo ; Mast, Yvonne ; Méndez, Carmen ; Metsä-Ketelä, Mikko ; Micklefield, Jason ; Mitchell, Douglas A. ; Moore, Bradley S. ; Moreira, Leonilde M. ; Müller, Rolf ; Neilan, Brett A. ; Nett, Markus ; Nielsen, Jens ; O'Gara, Fergal ; Oikawa, Hideaki ; Osbourn, Anne ; Osburne, Marcia S. ; Ostash, Bohdan ; Payne, Shelley M. ; Pernodet, Jean Luc ; Petricek, Miroslav ; Piel, Jörn ; Ploux, Olivier ; Raaijmakers, Jos M. ; Salas, José A. ; Schmitt, Esther K. ; Scott, Barry ; Seipke, Ryan F. ; Shen, Ben ; Sherman, David H. ; Sivonen, Kaarina ; Smanski, Michael J. ; Sosio, Margherita ; Stegmann, Evi ; Süssmuth, Roderich D. ; Tahlan, Kapil ; Thomas, Christopher M. ; Tang, Yi ; Truman, Andrew W. ; Viaud, Muriel ; Walton, Jonathan D. ; Walsh, Christopher T. ; Weber, Tilmann ; Wezel, Gilles P. Van; Wilkinson, Barrie ; Willey, Joanne M. ; Wohlleben, Wolfgang ; Wright, Gerard D. ; Ziemert, Nadine ; Zhang, Changsheng ; Zotchev, Sergey B. ; Breitling, Rainer ; Takano, Eriko ; Glöckner, Frank Oliver - \ 2015
Nature Chemical Biology 11 (2015)9. - ISSN 1552-4450 - p. 625 - 631.

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

New bird records for the Island of St. Eustatius, Dutch Caribbean, with notes on other significant sightings
Madden, H. ; Hensen, Roberto ; Piontek, S. ; Walton, Steffan ; Verdaat, J.P. ; Geelhoed, S.C.V. ; Stapel, J. ; Debrot, A.O. - \ 2015
The Journal of Caribbean Ornithology 28 (2015). - ISSN 1544-4953 - p. 28 - 34.
avifauna - Dutch Caribbean - Netherlands Antilles - St. Eustatius
The avifauna of the Dutch Caribbean island of St. Eustatius has been little studied. We document 22 new bird species for the island and update the status of several important species based on our recent observations. The documented avifauna of
the island amounts to 75 published species records. We conclude by pointing out several positive developments in the avifauna and ascribe these to the combined effects of reduced hunting, the legal establishment of protected park areas, and a growing environmental awareness among the island’s inhabitants
Effects of nurses' Screening of spiritual needs of hospitalized patients on consultation and perceived nurses' support and patients' spiritual well-being
Vlasblom, Jan P. ; Steen, Jenny T. Van Der; Walton, Martin N. ; Jochemsen, H. - \ 2015
Holistic Nursing Practice 29 (2015)6. - ISSN 0887-9311 - p. 346 - 356.
Spiritual assessment - Spiritual care - Spiritual screening

There is an undeniable relationship between spirituality and health, and taking a spiritual history is a simple way to increase the focus on spiritual care. This is a pre/posttest intervention study. Questionnaires were administered before implementation of a spiritual assessment (pretest, n = 106), and afterward (posttest, n = 103). Despite a difficult implementation process, the number of consultation requests for the Department of Spiritual and Pastoral Care increased from 2 in the pretest period to 33 in the posttest period. After adjusting for patient characteristics, we found no differences between pretest and posttest measurements on the FACIT-Sp-12 total score or nurses' support regarding dealing with illness; we did, however, find a significant decrease on the subscale Faith of the FACIT-Sp-12 and on nurses' support regarding questions about purpose and meaning (97%-83%). In conclusion, taking a spiritual history may contribute to the spiritual care of patients in a general hospital in the shape of more frequent referrals to the spiritual caregiver (chaplain), but further research is needed to determine whether this also means that nurses provide less spiritual care.

Photothermal Colloid Antibodies for Shape-Selective Recognition and Killing of Microorganisms
Borovicka, J. ; Metheringham, W.J. ; Madden, L.A. ; Walton, C.D. ; Stoyanov, S.D. ; Paunov, V.N. - \ 2013
Journal of the American Chemical Society 135 (2013)14. - ISSN 0002-7863 - p. 5282 - 5285.
tobacco-mosaic-virus - gold nanoparticles - pathogenic bacteria - cancer-cells - lysis - challenge - nanorods - therapy
We have developed a class of selective antimicrobial agents based on the recognition of the shape and size of the bacterial cells. These agents are anisotropic colloid particles fabricated as negative replicas of the target cells which involve templating of the cells with shells of inert material followed by their fragmentation. The cell shape recognition by such shell fragments is due to the increased area of surface contact between the cells and their matching shell fragments which resembles antibody-antigen interaction. We produced such "colloid antibodies" with photothermal mechanism for shape-selective killing of matching cells. This was achieved by the subsequent deposition of (i) gold nanoparticles (AuNPs) and (ii) silica shell over yeast cells, which were chosen as model pathogens. We demonstrated that fragments of these composite AuNP/silica shells act as "colloid antibodies" and can bind to yeast cells of the same shape and size and deliver AuNPs directly onto their surface. We showed that after laser irradiation, the localized heating around the AuNPs kills the microbial cells of matching shape. We confirmed the cell shape-specific killing by photothermal colloid antibodies in a mixture of two bacterial cultures of different cell shape and size. This approach opens a number of avenues for building powerful selective biocides based on combinations of colloid antibodies and cell-killing strategies which can be applied in new antibacterial therapies.
Viscous Food Matrix Influences Absorption and Excretion but Not Metabolism of Blackcurrant Anthocyanins in Rats
Walton, M.C. ; Hendriks, W.H. ; Broomfield, A.M. ; McGhie, T.K. - \ 2009
Journal of Food Science 74 (2009)1. - ISSN 0022-1147 - p. H22 - H29.
dietary cyanidin 3-o-beta-d-glucoside - ischemia-reperfusion injury - antioxidant activity - lipid-peroxidation - weanling pigs - elderly women - ribes-nigrum - human urine - humans - consumption
The aim of the present study was to investigate the effect of a simultaneous intake of food and anthocyanins (ACNs) on ACN absorption, metabolism, and excretion. Blackcurrant ACNs (BcACNs) were dissolved in water with or without the addition of oatmeal and orally administered to rats, providing approximately 250 mg total ACNs per kilogram BW. Blood, urine, digesta, and tissue samples of the stomach, jejunum, and colon were subsequently collected at 0.25, 0.5, 1, 2, 3, 7, and 24 h. Identification and quantification of ACNs were carried out by Reversed phase-high-performance liquid chromatography (RP-HPLC) and liquid chromatography-mass spectrometry (LC-MS). Four major ACNs were present in the blackcurrant extract: delphinidin 3-O-glucoside, delphinidin 3-O-rutinoside, cyanidin 3-O-glucoside, and cyanidin 3-O-rutinoside. In plasma, the 4 ACNs of blackcurrant were identified and quantified. The time to reach maximal total ACN plasma concentration (Cmax BcACN/water = 0.37 ± 0.07 µmol/L; Cmax BcACN/oatmeal = 0.20 ± 0.05 µmol/L) occurred faster after BcACN/water (tmax= 0.25 h), than after BcACN/oatmeal administration (tmax= 1.0 h). In digesta and tissue samples, the 4 original blackcurrant ACNs were detected. The relative concentration of rutinosides in the digesta increased during their passage through the gastrointestinal tract, while the glucosides decreased. Maximum ACN excretion in urine occurred later after BcACN/oatmeal than after BcACN/water administration (3 compared with 2 h). The 4 original ACNs of blackcurrant in their unchanged form, as well as several metabolites, were identified in the urine samples of both groups. The simultaneous intake of food affects ACN absorption and excretion in the urine, but not metabolism.
Fynbos Biome
Rebelo, A.G. ; Boucher, C. ; Helme, N. ; Mucina, L. ; Rutherford, M.C. ; Smit, W.J. ; Powrie, L.W. ; Ellis, F. ; Lambrechts, J.J.N. ; Scott, L. ; Radloff, F.G.T. ; Johnson, S.D. ; Richardson, D.M. ; Ward, R.A. ; Proche, S.M. ; Oliver, E.G.H. ; Manning, J.C. ; Jürgens, N. ; McDonald, D.J. ; Janssen, J.A.M. ; Walton, B.A. ; Roux, A. le; Skowno, A.L. ; Todd, S.W. ; Hoare, D.B. - \ 2006
In: The vegetation of South Africa, Lesotho and Swaziland / Mucina, L., Rutherford, M.C., Pretoria (South Africa) : SANBI (Sterlitzia 19) - ISBN 9781919976211 - p. 52 - 219.
The Flavonol Quercetin-3-Glucoside Inhibits Cyanidin-3-Glucoside Absorption in Vitro
Walton, M.C. ; McGhie, T.K. ; Reynolds, G.W. ; Hendriks, W.H. - \ 2006
Journal of Agricultural and Food Chemistry 54 (2006)13. - ISSN 0021-8561 - p. 4913 - 4920.
dependent glucose-transporter - lactase-phlorhizin hydrolase - small-intestinal lactase - brush-border-membrane - rat small-intestine - substrate-specificity - quercetin glucosides - mouse jejunum - elderly women - anthocyanins
At present, little is known about the mechanisms responsible for intestinal absorption of anthocyanins (ACNs). For example, it has not yet been established if ACNs are absorbed through an active transport mechanism, such as the sodium-dependent glucose transporter (SGLT1), or by passive diffusion. Previously, we found that the absorption of ACNs differs between regions of the digestive tract and is maximal in the jejunum, suggesting that an active transport mechanism is involved. In the present study, we examined the effect of D-glucose (main substrate of SGLT1), phloridzin (inhibitor of SGLT1), and quercetin-3-glucose (Q3G, a flavonol) on the absorption of cyanidin-3-glucoside (C3G; ~5 mol/L) by mouse jejunum mounted in Ussing chambers. We found that the presence of either D-glucose (10, 20, and 40 mmol/L) or phloridzin (50, 100, and 200 mol/L) resulted in a small but insignificant inhibition of C3G disappearance from the mucosal solution (decrease of disappearance with glucose, 33%; with phloridzin, 18%; NS). However, when the flavonol Q3G (50 mol/L) was added to the mucosal solution together with the C3G, the disappearance of C3G was significantly decreased (74%; p <0.001), and Q3G disappeared instead. In addition, we found phloretin and quercetin, the aglycones of phloridzin and Q3G, respectively, present in the mucosal solution and tissue extracts, indicating hydrolysis of these compounds by the enterocytes of the jejunum. In contrast, the aglycone cyanidin was not detected at all. Our results show that in the mouse small intestine, ACN absorption is not solely dependent on the activity of the SGLT1 transporter, as D-glucose and phloridzin had only a slight effect on uptake. Q3G, however, clearly inhibited C3G disappearance. These results suggest that there might be a competitive inhibition between C3G and Q3G absorption. It is possible that an absorption mechanism other than the SGLT1 is involved, which has a structural preference toward flavonols
Franssen, M.C.R. ; Walton, N.J. - \ 1999
In: Chemical from Plants / Walton, N.J., Brown, D.E., - p. 277 - 325.
Modern methods of secondary product isolation and analysis
Beek, T.A. van - \ 1999
In: Chemicals from plants / Walton, N.J., Brown, D.E., - p. 91 - 186.
Preengland oil and blood samples: non-destructive methods for monitoring organochlorine levels in Antarctic top predators
Brink, N.W. van den - \ 1997
In: Antarctic communities; species, structure and survival / Battaglia, B., Valencia, J., Walton, D.W.H., Cambridge : Cambridge University Press - p. 413 - 416.
Report of the fourth external Programme and Management Review of the Centro Internacional de Agricultura Tropical (CIAT), Cali, Colombia.
Walton, D.J. ; Scobie, G.M. ; Comerma, J. ; Dart, P. ; Jacobsen, E. ; Gell Mason, M. ; Cauphepe, M. ; Emechebe, A.M. ; Joshi, J. ; Sachdeva, P.P. ; Collinson, M. - \ 1995
Unknown Publisher - 107 p.
Report of the 1990 Program and management review of the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT).
Henzell, E.F. ; Walton, D.J. ; Zadoks, J.C. - \ 1990
Unknown Publisher - 181 p.
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