Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Current Status and Recommendations for Future Research1–3,
Rijkers, G.T. ; Bengmark, S. ; Enck, P. ; Haller, D. ; Herz, U. ; Kalliomäki, M. ; Kudo, S. ; Lenoi-Winkoop, I. ; Mercenier, A.M.E. ; Myllyluoma, E. ; Rabot, S. ; Rafter, J. ; Szajewska, H. ; Watzl, B. ; Wells, J. ; Wolvers, D. ; Antoine, J.M. - \ 2010
The Journal of Nutrition 140 (2010)3. - ISSN 0022-3166 - p. 671S - 676S.
lactobacillus-plantarum - gastrointestinal-tract - healthy-volunteers - survival - bacteria - yogurt - casei - feces - milk - 299v
Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. There is a growing interest in probiotics within the scientific community, with consumers, and in the food industry. The interactions between the gut and intestinal microbiota and between resident and transient microbiota define a new arena in physiology, an understanding of which would shed light on the "cross-talk" between humans and microbes. The different beneficial effects of specific probiotic strains may be translated into different health claims. However, there is a need for comprehensive and harmonized guidelines on the assessment of the characteristics and efficacy of probiotics and of foods containing them. An international expert group of ILSI has evaluated the published evidence of the functionality of different probiotics in 4 areas of (human) application: 1) metabolism, 2) chronic intestinal inflammatory and functional disorders, 3) infections, and 4) allergy. Based on the existing evidence, concrete examples of demonstration of benefits and gaps are listed, and guidelines and recommendations are defined that should help design the next generation of probiotic studies
Germ cell development in larval and juvenile carp (Cyprinus carpio L.)
Winkoop, A. van - \ 1995
Agricultural University. Promotor(en): L.P.M. Timmermans. - S.l. : Van Winkoop - ISBN 9789054854067 - 168
kiemcellen - gameten - cyprinodontidae - karper - germ cells - gametes - carp
<p>This thesis describes the development of larval and juvenile gonads of a teleost fish, the common carp, with special attention to the differentiation of the primordial germ cells. The early gonadal development has received relatively little attention, hitherto, as the research on fish reproduction has been focussed mainly on germ cell maturation in adult fish species. The early development of gonads and germ cells, however, is highly important, as in that period a.o. sex determination occurs.<p>In the early larval period the gonadal tissue is gradually formed around the primordial germ cells (PGCs) which are already located at the sites of the future gonadal primordia. The PGCs in the developing larval gonads increase in size between week 2 and week 4 after fertilization. Concomitantly, ultrastructural changes occur in the cytoplasm and nuclei of these cells, which is supposed to be a preparation for the rapid proliferation of PGCs after week 6.<p>An important part of the investigations was devoted to the production of monoclonal antibodies (MAbs). In general, MAbs may recognise differentiation stages accurately. This enables the investigation of the factors which may influence such differentiation processes. The MAbs were raised against primary and early secondary spermatogonia. The procedures are presented how germ cells were isolated from testis tissue and how the percentage of these cells (diameter>10 μm) could be enriched with a percoll gradient from an initial 4% in the early spermatogenic testis to more than 70%.<p>One of the produced MAbs recognised antigens, appearing first in the cytoplasm and subsequently on the surface membrane of the enlarging PGCs in the larval gonads between week 2 and week 4. This supports the hypothesis that the enlarging PGCs are differentiating cells, possibly in preparation for the fast proliferation of PGCs after week 6. Four of the produced MAbs reacted with PGCs from the onset of PGC proliferation (after week 6) up to and including early (primary) spermatogonia in the adult testis (or oogonia in ovaries). This indicates that specific differentiation antigens are present on these cells. These MAbs may be used for the recognition of primary spermatogonia after isolation of germ cells for cell culture which is necessary for the investigation of factors which stimulate or inhibit specific steps, a.o. the onset of meiosis.<p>Furthermore, the possible stimulation of gonadal development in larval or juvenile carp by injection with homologous pituitary extract containing a.o. the gonadotropic hormone (GTH) was investigated. It was found in juvenile carp that the gonads were greatly enlarged and that precocious spermatogenesis occurred after injection of pituitary extract (confirming data obtained in other fish species after injection of GTH). However, also gonadal development and PGC proliferation in larval fish was stimulated. Such effect of pituitary extract on larval gonads and germ cells has not been reported previously. The evidence obtained indicates a function of GTH in this stimulation. The question, however, whether one of the MAb-recognised determinants is involved awaits elucidation.
Stimulation of gonadal and germ cell development in larval and juvenile carp (Cyprinus carpio L.) by homologous pituitary extract.
Winkoop, A. van; Timmermans, L.P.M. ; Goos, H.J.Th. - \ 1994
Fish Physiology and Biochemistry 13 (1994). - ISSN 0920-1742 - p. 161 - 171.
Recognition of surface antigens on spermatozoa of the common carp (Cyprinus carpio L., Teleostei) using monoclonal antibodies and scanning electron microscopy.
Winkoop, A. van; Dulos, G.J. ; Timmermans, L.P.M. - \ 1994
European journal of morphology 33 (1994). - ISSN 0924-3860 - p. 51 - 58.
Larval development of gonads and germ cells in teleost fish.
Timmermans, L.P.M. ; Winkoop, A. van - \ 1993
In: Physiological and biochemical aspects of development / Walther, B.T., Fyhn, H.J., - p. 67 - 71.
Effect of pituitary factors on gonad development and germ cell differentiation in larval and juvenile carp (Cyprinus carpio).
Timmermans, L.P.M. ; Winkoop, A. van - \ 1992
In: Proc. 2nd Int. Symp. Fish endocrinology, Saint-Malo, France - p. 42 - 42.
Ultrastructural changes in primordial germ cells during early gonadal development of the common carp (Cyprinus carpio L., Teleostei).
Winkoop, A. van; Booms, G.H.R. ; Dulos, G.J. ; Timmermans, L.P.M. - \ 1992
Cell and Tissue Research 267 (1992). - ISSN 0302-766X - p. 337 - 346.
Phenotypic changes in germ cells during gonadal development of the common carp (Cyprinus carpio). An immunohistochemical study with anti-carp spermatogonia monoclonal antibodies.
Winkoop, A. van; Timmermans, L.P.M. - \ 1992
Histochemistry 98 (1992). - ISSN 0301-5564 - p. 289 - 298.
Surface location and stage-specificity of differentiation antigens on germ cells in the common carp (Cyprinus carpio), as revealed with monoclonal antibodies and immunogold staining.
Winkoop, A. van; Timmermans, L.P.M. - \ 1990
Histochemistry 95 (1990). - ISSN 0301-5564 - p. 77 - 85.
Phenotypic changes prior to proliferation in primordial germ cells of the common carp.
Winkoop, A. van; Dulos, G.J. ; Timmermans, L.P.M. - \ 1990
Cell biology : international reports 14 (1990). - ISSN 0309-1651 - p. 377 - 377.
The early intragonadal development of primordial germ cells in carp (Cyprinus carpio L., Teleostei).
Winkoop, A. van - \ 1989
Cell Differentiation and Development 27 (1989)suppl. 1. - p. S163 - S163.
Distribution of antigenic determinants on carp spermatozoa as visualized with monoclonal antibodies and scanning electronmicroscopy.
Timmermans, L.P.M. ; Dulos, G.J. ; Winkoop, A. van - \ 1989
Cell Differentiation and Development 27 (1989)suppl. 1. - p. S162 - S162.
Antigen expression on spermatozoa of carp: a SEM and TEM study with immunogold labeling.
Timmermans, L.P.M. ; Dulos, G.J. ; Bouw, E. ; Boekestein, A. ; Winkoop, A. van - \ 1989
Ultramicroscopy 27 (1989). - ISSN 0304-3991 - p. 27 - 27.
Germ cell differentiation antigens in carp (Cyprinus carpio L.) defined by monoclonal antibodies.
Winkoop, A. van; Timmermans, L.P.M. - \ 1987
In: Poster Congr. Differentiation of normal and neoplastic cells, Boulder, Colorado, USA (1987)
Identification of differentiation antigens on male germ cells during development of carp. A study with monoclonal antibodies.
Winkoop, A. van; Timmermans, L.P.M. - \ 1987
In: Poster Wetensch. Verg. Ned. Ver. Ontwikkelingsbiologie, Amsterdam (1987)
The expression of germ cell specific markers as defined with monoclonal antibodies in correlation with the ontogeny of gonadotropin production in carp.
Winkoop, A. van; Timmermans, L.P.M. - \ 1987
In: Poster 3rd Int. Symp. Reproductive physiology of fish, St. Johns, Canada (1987)
Differentiation antigens of gametogenesis in carp (Cyprinus carpio L., Teleostei).
Timmermans, L.P.M. ; Winkoop, A. van - \ 1987
Cell Differentiation and Development 20 (1987)suppl.. - p. 155 - 155.
Immunological approaches to control maturation in fish. 1. Cytotoxic reactions against germ cells using monoclonal antibodies.
Secombes, C.J. ; Winkoop, A. van; Boogaart, J.G.M. van den; Timmermans, L.P.M. ; Priede, I.G. - \ 1986
Aquaculture 52 (1986). - ISSN 0044-8486 - p. 125 - 135.
Cytotoxicity of monoclonal antibodies with male germ cells of carp (Cyprinus carpio L.) and the penetrability of these antibodies into the testis.
Timmermans, L.P.M. ; Winkoop, A. van; Boogaart, J.G.M. van den - \ 1986
In: Abstract Symp. Ned. Ver. Celbiologie, Nijmegen - p. 42 - 42.
Cell surface antigens restricted to early spermatogenic cells in the common carp (Cyprinus carpio L.).
Winkoop, A. van; Timmermans, L.P.M. - \ 1986
In: Abstract Symp. The cytoskeleton: cell function and organization. Brit. Soc. Cell Biol./Brit. Soc. Devel. Biol., Norwich, UK (1986) nr. 84
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