2026-06-10T12:35:03+02:00 https://library.wur.nl/oai

oai:library.wur.nl:wurpubs/401276 2026-03-31

urn:nbn:nl:ui:32-401276 2026-03-31 urn:nbn:nl:ui:32-401276/mods Small intestinal segment perfusion test in piglets: future applications in studying probiotics-gut crosstalk in infectious diarrhoea? van der Meulen J. 074739751 0000000393669223 aut Hulst M.M. 237918668 0000-0001-8020-8853 0000000389965636 aut Smits M.A. 068839472 0000000394811295 aut Schuurman T. 314623000 0000-0001-7156-6288 0000000388712258 aut text info:eu-repo/semantics/article 2010 10.3920/BM2010.0025 2-s2.0-79954598275 000208381000015 en Worldwide infectious diarrhoea, mainly caused by rotavirus and enterotoxigenic Escherichia coli (ETEC), accounts for a large part of deaths in children. ETEC is also the main cause of traveller's diarrhoea. Probiotics are promising for prevention and treatment of diarrhoea, but there is insufficient evidence to support the use of any specific probiotic or probiotics in general. Because of the sensitivity of suckling and weaned piglets for ETEC, piglets are a good model for infectious diarrhoea in infants and traveller's diarrhoea. Just as in human the efficacy of probiotics in diminishing diarrhoea and improving growth in suckling and weaned piglets is not uniform. A piglet model of infectious diarrhoea provides access to intestinal compartments that are not easily accessible in infants. In an in situ piglet model of secretory diarrhoea, the functional physiological response to ETEC and the concomitant host genome response to ETEC and probiotics may be tested. This will provide new insights in the complex crosstalk between ETEC, probiotics and the gut in the future. WIAS Wageningen Livestock Research Animal Nutrition Animal Breeding & Genomics Host-Microbe Interactomics Infants Infectious diarrhoea Piglet Probiotics WIAS Wageningen Livestock Research Diervoeding Fokkerij & Genomica Host-Microbe Interactomics Beneficial Microbes 1 4 439 445 18762883 urn:nbn:nl:ui:32-401276/obj 2026-03-31 http://purl.org/eprint/accessRights/RestrictedAccess