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                    <mods:abstract lang="eng">Potato (Solanum tuberosum L.) is the world’s most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop</mods:abstract>
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                      <mods:topic>EPS-3</mods:topic>
                      <mods:topic>Plant Breeding</mods:topic>
                      <mods:topic>Nematology (NEM)</mods:topic>
                      <mods:topic>Plant Breeding (PBR)</mods:topic>
                      <mods:topic>BIOS Applied Bioinformatics</mods:topic>
                      <mods:topic>Bioinformatics (BIF)</mods:topic>
                      <mods:topic>elements</mods:topic>
                      <mods:topic>eukaryotic genomes</mods:topic>
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                      <mods:topic>maize</mods:topic>
                      <mods:topic>resistance genes</mods:topic>
                      <mods:topic>reveals</mods:topic>
                      <mods:topic>rna-seq</mods:topic>
                      <mods:topic>solanum</mods:topic>
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                      <mods:topic>EPS-3</mods:topic>
                      <mods:topic>Plant Breeding</mods:topic>
                      <mods:topic>Nematology (NEM)</mods:topic>
                      <mods:topic>Plant Breeding (PBR)</mods:topic>
                      <mods:topic>BIOS Applied Bioinformatics</mods:topic>
                      <mods:topic>Bioinformatics (BIF)</mods:topic>
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