2013-05-23T01:49:25Zhttp://library.wur.nl/oai

oai:library.wur.nl:wurpubs/371491 2012-05-29

urn:nbn:nl:ui:32-371491 2012-05-29 urn:nbn:nl:ui:32-371491/mods Transmission of highly pathogenic avian influenza H5N1 virus in Pekin ducks is significantly reduced by a genetically distant H5N2 vaccine Goot, van der J.A. aut Boven, van M. aut Stegeman A. aut Water, van de S.G.P. aut Jong, de M.C.M. aut Koch G. aut 314614109 16328959X 304080942 330647350 06887992X text info:eu-repo/semantics/article 2008 en Domestic ducks play an important role in the epidemiology of H5N1 avian influenza. Although it is known that vaccines that have a high homology with the challenge virus are able to prevent infection in ducks, little is yet known about the ability of genetically more distant vaccines in preventing infection, disease, and transmission. Here we study the effect of a widely used H5N2 vaccine (A/Chicken/Mexico/232/94/CPA) on the transmission of H5N1 virus (A/Chicken/China/1204/04) in ducks. The quantitative analyses show that despite the low level of homology between the virus and vaccine strain transmission was significantly reduced two weeks after a single or double vaccination. Mortality and disease rates were reduced markedly already one week after a single vaccination. Infectieziekten Divisie Virologie Leerstoelgroep Kwantitatieve veterinaire epidemiologie Virology 382 1 91 97 URN:ISSN:0042-6822 urn:nbn:nl:ui:32-371491/obj 2010-01-14 qhttp://purl.org/eprint/accessRights/RestrictedAccess