2013-05-25T21:11:54Zhttp://library.wur.nl/oai

oai:library.wur.nl:wurpubs/401276 2013-05-04

urn:nbn:nl:ui:32-401276 2013-05-04 urn:nbn:nl:ui:32-401276/mods Small intestinal segment perfusion test in piglets: future applications in studying probiotics-gut crosstalk in infectious diarrhoea? Meulen, van der J. aut Hulst M.M. aut Smits M.A. aut Schuurman T. aut 074739751 237918668 068839472 314623000 text info:eu-repo/semantics/article 2010 en Worldwide infectious diarrhoea, mainly caused by rotavirus and enterotoxigenic Escherichia coli (ETEC), accounts for a large part of deaths in children. ETEC is also the main cause of traveller's diarrhoea. Probiotics are promising for prevention and treatment of diarrhoea, but there is insufficient evidence to support the use of any specific probiotic or probiotics in general. Because of the sensitivity of suckling and weaned piglets for ETEC, piglets are a good model for infectious diarrhoea in infants and traveller's diarrhoea. Just as in human the efficacy of probiotics in diminishing diarrhoea and improving growth in suckling and weaned piglets is not uniform. A piglet model of infectious diarrhoea provides access to intestinal compartments that are not easily accessible in infants. In an in situ piglet model of secretory diarrhoea, the functional physiological response to ETEC and the concomitant host genome response to ETEC and probiotics may be tested. This will provide new insights in the complex crosstalk between ETEC, probiotics and the gut in the future. Leerstoelgroep Fokkerij en genetica LR - Backoffice Wageningen UR Livestock Research Beneficial Microbes 1 4 439 445 URN:ISSN:1876-2883 urn:nbn:nl:ui:32-401276/obj 2011-01-21 qhttp://purl.org/eprint/accessRights/RestrictedAccess