Record nummer 1940798
Titel artikel Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition
Auteur(s) Cao, L. ; Liu, X. ; Lin, E.-J.D. ; Wang, C. ; Choi, E.Y. ; Riban, V. ; Lin, B. ; During, M.J.
Tijdschrifttitel Cell
Deel(Jaar)Nummer 142(2010)1
Paginering 52 - 64
Online full text
Trefwoorden (cab) muizen / laboratoriumdieren / neoplasma's / huisvesting, dieren / habitats / dierenwelzijn / ziektebeloop / hypothalamische regulatie / leptine
Rubrieken Dierpathologie / Laboratoriumdieren / Humane pathologie
Publicatie type Artikel
Taal Engels
Toelichting (Engels) Cancer is influenced by its microenvironment, yet broader, environmental effects also play a role but remain poorly defined. The authors report here that mice living in an enriched housing environment show reduced tumor growth and increased remission. They found this effect in melanoma and colon cancer models, and that it was not caused by physical activity alone. Serum from animals held in an enriched environment (EE) inhibited cancer proliferation in vitro and was markedly lower in leptin. Hypothalamic brain-derived neurotrophic factor (BDNF) was selectively upregulated by EE, and its genetic overexpression reduced tumor burden, whereas BDNF knockdown blocked the effect of EE. Mechanistically, we show that hypothalamic BDNF downregulated leptin production in adipocytes via sympathoneural β-adrenergic signaling. These results suggest that genetic or environmental activation of this BDNF/leptin axis may have therapeutic significance for cancer.
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