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Record nummer 2033089
Titel artikel Metabolic modeling of denitrification in Agrobacterium tumefaciens: a tool to study inhibiting and activating compounds for the denitrification pathway
Auteur(s) Kampscheur, M.J. ; Kleerebezem, R. ; Picioreanu, C. ; Bakken, L. ; Bergaust, L. ; Vries, S. de ; Jetten, M.S.M. ; Loosdrecht, M.C.M. van
Tijdschrifttitel Frontiers in cellular and infection microbiology
Deel(Jaar)Nummer 3 (October)(2012)370
Online full text
Trefwoorden (cab) denitrificatie / rhizobium radiobacter / metabolische studies / modellen / stikstofoxide / reductie / distikstofmonoxide / cytochroom-c oxidase / stikstofkringloop / enzymactiviteit / afvalwaterbehandeling
Rubrieken Afvalwaterbehandeling
Publicatie type Artikel
Taal Engels
Toelichting (Engels) A metabolic network model for facultative denitrification was developed based on experimental data obtained with Agrobacterium tumefaciens. The model includes kinetic regulation at the enzyme level and transcription regulation at the enzyme synthesis level. The objective of this work was to study the key factors regulating the metabolic response of the denitrification pathway to transition from oxic to anoxic respiration and to find parameter values for the biological processes that were modeled. The metabolic model was used to test hypotheses that were formulated based on the experimental results and offers a structured look on the processes that occur in the cell during transition in respiration. The main phenomena that were modeled are the inhibition of the cytochrome c oxidase by nitric oxide (NO) and the (indirect) inhibition of oxygen on the denitrification enzymes.
Betrokken instanties Technische Universiteit Delft, Vakgroep Bioprocestechnologie
Waterschap Aa en Maas
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