Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 110771
Title Delayed effect of the vasopressin metabolite VP4-8 on the social memory of sexually naive male rats
Author(s) Reijmers, L.G.J.E.; Baars, A.M.; Burbach, J.P.H.; Spruijt, B.M.
Source Psychopharmacology 154 (2001)4. - ISSN 0033-3158 - p. 408 - 414.
DOI https://doi.org/10.1007/s002130000672
Department(s) Chair Ethology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2001
Abstract Rationale: Endogenous vasopressin is involved in the social memory of the male rat and administration of exogenous vasopressin improves social memory. These findings are mainly based on studies using sexually experienced males that were tested in the social recognition test. Objective: The present study was aimed to establish whether the modulation of social memory by vasopressin fragments depends on the sexual experience of the male rat. For this purpose, the social discrimination test was used, since this test is more suitable than the social recognition test for measuring social memory in sexually naive males. Methods: Male rats were tested in the social discrimination test and treated subcutaneously with the vasopressin metabolite [pGlu4,Cyt6]vasopressin-(4-8) (VP4-8). VP4-8 shares with vasopressin the effects on memory processes but lacks the peripheral effects of vasopressin. Results: VP4-8 (1 μg/kg) acutely improved the social memory of sexually experienced male rats, confirming previous reports. However, in sexually naive males VP4-8 failed to improve social memory in doses ranging from 0.1 μg/kg to 1 μg/kg. Instead, 1 μg/kg VP4-8 or 6 μg/kg desglycinamide-vasopressin were found to exert a delayed effect in sexually naive rats. This delayed effect resulted in an improved social memory 2 days after administration. Conclusions: Vasopressin sensitisation is discussed as a possible underlying mechanism of the observed delayed effect of vasopressin fragments. It is concluded that in male rats sexual experience can influence the modulation of social memory by vasopressin.
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