Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 110773
Title Chronic imipramine treatment partially reverses the long-term changes of hippocampal synaptic plasticity in socially stressed rats
Author(s) Frijtag, J.C. von; Kamal, A.; Reijmers, L.G.J.E.; Schrama, L.H.; Bos, R. van den; Spruijt, B.M.
Source Neuroscience Letters 309 (2001). - ISSN 0304-3940 - p. 153 - 156.
DOI https://doi.org/10.1016/S0304-3940(01)02062-6
Department(s) Chair Ethology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2001
Abstract In the present study, we investigated whether synaptic plasticity changes in the hippocampus of depressive-like socially stressed rats could be reversed by chronic antidepressant treatment. To that end, rats were either defeated and subsequently individually housed or subjected to control treatment followed by social housing. After a period of at least 3 months, rats were either treated chronically with imipramine (20 mg/kg per day, per os for at least 3 months) or the solvent solution (i.e. water). Then, long-term potentiation and depression were measured in the CA1 region of the hippocampus in vitro. Chronic imipramine treatment partially restored the attenuated induction of long-term potentiation and suppressed the facilitation of long-term depression-induction in socially stressed rats. The altered synaptic plasticity after social stress is discussed in relation to cognitive deficits and hippocampal changes that are observed in depressive patients.
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