Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 110775
Title Long-term impairment of social memory in the rat after social defeat is not restored by desglycinamide-vasopressin
Author(s) Reijmers, L.G.J.E.; Hoekstra, K.; Burbach, J.P.H.; Ree, J.M. van; Spruijt, B.M.
Source Neuroscience Letters 305 (2001). - ISSN 0304-3940 - p. 145 - 148.
Department(s) Chair Ethology
Publication type Refereed Article in a scientific journal
Publication year 2001
Abstract Repeated social defeat followed by individual housing caused a long-term impairment of social memory in male rats. Social memory, as assessed in the social discrimination test using an intertrial interval of 3 min, was impaired for at least 8 weeks after the social defeat experience. Since social memory of male rodents depends on proper functioning of the sexually dimorphic vasopressin system, it was investigated whether a centrally active vasopressin fragment could restore the impaired social memory. Subcutaneous administration of 6 g/kg of the vasopressin fragment desglycinamide-vasopressin (VP1–8) 40 days after social defeat slightly improved social memory in both control and socially defeated rats. It is concluded that social defeat followed by individual housing caused a long-term impairment of social memory, which was not restored by treatment with VP1–8.
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