Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 110953
Title The effect of ethanol on the kinetics of lipase-mediated enantioselective esterification of 4-methyloctanoic acid and the hydrolysis of its ethyl ester
Author(s) Heinsman, N.W.J.T.; Valente, A.M.; Schmienk, H.G.F.; Padt, A. van der; Franssen, M.C.R.; Groot, Æ. de; Riet, K. van 't
Source Biotechnology and Bioengineering 76 (2001)3. - ISSN 0006-3592 - p. 193 - 199.
Department(s) Organic Chemistry
Sub-department of Food and Bioprocess Engineering
Publication type Refereed Article in a scientific journal
Publication year 2001
Abstract The Novozym 435? catalyzed esterification and hydrolysis reactions of 4-methyloctanoic acid (ethyl ester) were investigated. In both the hydrolysis and esterification reactions, the increase of ethanol concentration led to an increase in enantiomeric ratio (E). For hydrolysis of the ethyl ester, the E-value increased from 5.5 [0øv/v) EtOH] up to 12 [20øv/v) EtOH]. In case of esterification, the E-value was already 16 [14øv/v) EtOH] and rose to 57 [73øv/v) EtOH]. When combining these results of esterification and hydrolysis, an enantiomeric ratio of 350 can be estimated for the sequential kinetic resolution of 4-methyloctanoic acid. In this way, enantiopure 4-methyloctanoic acid could be obtained after two consecutive reaction steps
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