Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 120609
Title Original communication: Basal metabolic rate in children with a solid tumor
Author(s) Broeder, E. den; Oeseburg, B.; Lippens, R.J.J.; Staveren, W.A. van; Sengers, R.C.A.; Hof, M.A. van 't; Tolboom, J.J.M.
Source European Journal of Clinical Nutrition 55 (2001). - ISSN 0954-3007 - p. 673 - 681.
Department(s) Human Nutrition & Health
Publication type Refereed Article in a scientific journal
Publication year 2001
Abstract Objective: To study the level of and changes in basal metabolic rate (BMR) in children with a solid tumour at diagnosis and during treatment in order to provide a more accurate estimate of energy requirements for nutritional support. Design: An observational study. Setting: Tertiary care at the Centre for Paediatric Oncology, University Hospital Nijmegen. Subjects: Thirteen patients were recruited from a population of patients visiting the University Hospital Nijmegen for treatment. All patients asked to participate took part in and completed the study. Intervention: BMR was measured by indirect calorimetry, under stringent, standardised conditions, for 20 min and on three different occasions in all patients. Continuous breath gas analysis using a mouthpiece was performed. Weight, height and skinfold measurements were performed before each measurement. Main outcome measures: BMR was expressed as percentage of the estimated reference value, according to the Schofield formulas based on age, weight and sex, and in kJ (kcal) per kg of fat-free mass. Results: At diagnosis, the BMR was higher than the estimated reference BMR in all patients and 44␘f the patients were considered hypermetabolic. Mean BMR (as percentage of reference) was significantly increased (11.6øs.d. 6.7› P=0.001), but decreased during treatment in 12 of the 13 patients (mean decrease 12.7øs.d. 3.9› P<0.0001). Furthermore, a significant negative correlation (P=-0.67; P=0.01) was found between the change in BMR and tumour response. Conclusions: These data suggest that the BMR of children with a solid tumour is increased at diagnosis and possibly during the first phase of oncologic treatment. This may be important when determining energy requirements for nutritional support
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