1,2,3-TriCP can cause cancer. Various types of genotoxicity tests have shown both negative and positive results. It is not certain that the positive results found in in vitro test systems will also occur in vivo However, the committee feels that, based on the available data, the substance should be considered as genotoxic. This implies that there is a risk attached to each exposure. The committee bases its evaluation of the health risk for those exposed at work on experimental animal data and uses linear extrapolation to calculate the additional risk of tumour development. It takes as starting point a study in which rats were exposed orally to 1,2,3-TriCP. Based on the tumour incidence in the lowest dose group and using linear extrapolation, a life-long risk for exposure at work was estimated (i.e. exposure for 40 years, 8 hours each working day, 5 days a week). An additional incidence of tumours can be expected: - 4 x 10(exp-5) at a 1,2,3-TriCP concentration of 1.08 ug/m3 (0.18 ppb) - 4 x 10(exp-3) at a 1,2,3-TriCP concentration of 108 ug/m3 (17.7 ppb). The committee recommends a skin notation.
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