Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 26653
Title Health Council of The Netherlands: Dutch Expert Committee on Occupational Standards (DECOS). 1,2,3-Trichloropropane.
Author(s) Maclaine Pont, M.A.
Source Unknown Publisher - 91 p.
Department(s) Toxicology
Publication type Scientific report
Publication year 1994
Abstract 1,2,3-TriCP can cause cancer. Various types of genotoxicity tests have shown both negative and positive results. It is not certain that the positive results found in in vitro test systems will also occur in vivo However, the committee feels that, based on the available data, the substance should be considered as genotoxic. This implies that there is a risk attached to each exposure. The committee bases its evaluation of the health risk for those exposed at work on experimental animal data and uses linear extrapolation to calculate the additional risk of tumour development. It takes as starting point a study in which rats were exposed orally to 1,2,3-TriCP. Based on the tumour incidence in the lowest dose group and using linear extrapolation, a life-long risk for exposure at work was estimated (i.e. exposure for 40 years, 8 hours each working day, 5 days a week). An additional incidence of tumours can be expected: - 4 x 10(exp-5) at a 1,2,3-TriCP concentration of 1.08 ug/m3 (0.18 ppb) - 4 x 10(exp-3) at a 1,2,3-TriCP concentration of 108 ug/m3 (17.7 ppb). The committee recommends a skin notation.
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