Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 318821
Title Contribution of caffeine to the homocysteine-raising effect of coffee : a randomized controlled trial in humans
Author(s) Verhoef, P.; Pasman, W.J.; Vliet, T. van; Urgert, R.; Katan, M.B.
Source American Journal of Clinical Nutrition 76 (2002). - ISSN 0002-9165 - p. 1244 - 1248.
Department(s) Physics and Physical Chemistry of Foods
Human Nutrition & Health
Publication type Refereed Article in a scientific journal
Publication year 2002
Abstract Background: A high plasma total homocysteine concentration is associated with increased risk of cardiovascular disease. Consumption of unfiltered or filtered coffee raises total homocysteine concentrations in healthy volunteers. The responsible compound, however, is unknown. Objective: The objective was to determine whether caffeine explains the homocysteine-raising effect of coffee. Design: Forty-eight subjects aged 19–65 y completed this randomized crossover study with 3 treatments, each lasting 2 wk. Subjects consumed 6 capsules providing 870 mg caffeine/d (test treatment), 0.9 L paper-filtered coffee providing 870 mg caffeine/d, or 6 placebo capsules. Blood samples were drawn fasting and 4 h after consumption of 0.45 L coffee or 3 capsules. Results: The mean fasting plasma homocysteine concentration after the placebo treatment was 9.6 ± 3.1 ?mol/L. The caffeine and coffee treatments increased fasting homocysteine by 0.4 ?mol/L (95% CI: 0.1, 0.7; P = 0.04), or 5%, and by 0.9 ?mol/L (95% CI: 0.6, 1.2; P = 0.0001), or 11%, respectively, compared with placebo. The increase in homocysteine concentrations 4 h after consumption of 0.45 L coffee relative to consumption of 3 placebo capsules was 19% (P = 0.0001). Caffeine treatment had a much weaker acute effect on homocysteine (4%; P = 0.09). Effects of caffeine were stronger in women than in men, but the effects of coffee did not differ significantly between men and women. Conclusions: Caffeine is partly responsible for the homocysteine-raising effect of coffee. Coffee, but not caffeine, affects homocysteine metabolism within hours after intake, although the effect is still substantial after an overnight fast. Key Words: Caffeine … paper-filtered coffee … homocysteine … B vitamins … crossover experiment
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