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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 321698
Title Hydrodynamics of a liquid-liquid-solid fluidized-bed bioreactor
Author(s) Zessen, E. van
Source Wageningen University. Promotor(en): Hans Tramper, co-promotor(en): Arjen Rinzema; Rik Beeftink. - [S.l.] : S.n. - ISBN 9789058088758 - 199
Department(s) Bioprocess Engineering
VLAG
Publication type Dissertation, internally prepared
Publication year 2003
Keyword(s) bioreactoren - hydrodynamica - wervelbedden - fermentatie - biotechnologie - bioreactors - hydrodynamics - fluidized beds - fermentation - biotechnology
Categories Reactor Engineering
Abstract If a batchwise bioconversion and subsequent ( i.e. serial) downstream processing are adopted as a standard production strategy, a low overall productivity may result for certain types of biotransformations (substrate- or product-inhibited fermentations). An alternative to sequential processing would be the integration of bioconversion and downstream processing by controlled supply of substrate to the reaction in situ , or by controlled removal of product from the reaction in situ . Such integration involves a multi-phase reactor in which a helper phase may serve as substrate reservoir or as product sink. A new type of multi-phase bioreactor was developed, containing a continuous liquid phase, a dispersed liquid phase, and a dispersed solid phase; it may be conceived of as a 3-phase liquid-liquid-solid fluidized bed. This thesis focuses on the hydrodynamic aspects of such a 3-phase fluidized bed; a general design strategy was developed. Within this 3-phase system, a liquid-solid fluidized bed consisting of biocatalytic gel beads in a continuous medium phase, and a liquid-liquid extraction column or spray column, consisting of organic droplets in a continuous medium phase can be discerned. The hydrodynamic characteristics of these constituent 2-phase systems were studied as well. At the end this thesis reviews the current status of the newly developed 3-phase liquid-liquid-solid fluidized-bed bioreactor; it outlines additional research to be performed for a full understanding of its hydrodynamicbehavior. Additional steps that have to be taken for practical implementation of the 3-phase fluidized bed as a new type of bioreactor are emphasized.

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