Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 322220
Title The peptide antibiotic Clavanin A interacts strongly and specifically with lipid bilayers
Author(s) Kan, E.J.M. van; Ganchev, D.N.; Snel, M.M.E.; Chupin, V.; Bent, A. van der; Kruijff, B. de
Source Biochemistry 42 (2003)38. - ISSN 0006-2960 - p. 11366 - 11372.
Department(s) Agrotechnological Research Institute
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) helical antimicrobial peptides - nuclear-magnetic-resonance - differential scanning calorimetry - x-ray-diffraction - phosphatidylcholine bilayers - model membranes - transmembrane peptides - biological-membranes - tunicate hemocytes - flanking residues
Abstract In this study the interaction of the antimicrobial peptide clavanin A with phosphatidylcholine bilayers is investigated by DSC, NMR, and AFM techniques. It is shown that the peptide interacts strongly and specifically with the lipids, resulting in increased order-disorder phase transition temperatures, phase separation, altered acyl chain and headgroup packing, and a drastically changed surface morphology of the bilayer. These results are interpreted in terms of clavanin-specific interactions with lipids and are discussed in the light of the different mechanisms by which clavanin A can destroy the barrier function of biological membranes
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