Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 325431
Title Design and analysis of an actinobacillus pleuropneumoniae transmission experiment
Author(s) Velthuis, A.G.J.; Jong, M.C.M. de; Kamp, E.M.; Stockhofe, N.; Verheijden, J.H.M.
Source Preventive Veterinary Medicine 60 (2003). - ISSN 0167-5877 - p. 53 - 68.
Department(s) Business Economics
Quantitative Veterinary Epidemiology
ID - Infectieziekten
CIDC - Divisie Bacteriologie en TSE's
ASG Infectieziekten
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) pseudorabies virus - endobronchial inoculation - vaccinated pigs - apx toxins - antibodies - excretion - infection - challenge - immunity - efficacy
Abstract This paper describes a methodology to quantify the transmission of Actinobacillus (A.) pleuropneumoniae from subclinically infected carrier pigs to susceptible contact pigs, and to test the effect of possible interventions on the transmission. The methodology includes the design of a transmission experiment, and a method with which A. pleuropneumoniae transmission can be quantified and with which the effect of an intervention on the transmission can be tested. The experimental design consists of two parts. First, subclinically infected carrier pigs are created by contact exposure of specific-pathogen-free pigs to endobronchially inoculated pigs. Second, transmission is observed from the group of carrier pigs to a second group of susceptible contact pigs after replacing the inoculated pigs by new contact pigs. The presented analytical method is a generalised linear model (GLM) with which the effect of an intervention on the susceptibility and infectivity can be tested separately, if the transmission is observed in heterogeneous populations. The concept of the experimental transmission model is illustrated by describing an A. pleuropneumoniae transmission experiment in which the effect of vaccination on the susceptibility is quantified. Although it could not be demonstrated that vaccination has an effect on the susceptibility of pigs, it was demonstrated that nasal excretion of A. pleuropneumoniae is related to the infectivity of pigs. (C) 2003 Elsevier Science B.V. All rights reserved.
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