Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 326169
Title Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjects
Author(s) Geelen, A.; Zock, P.L.; Swenne, C.A.; Brouwer, I.A.; Schouten, E.G.; Katan, M.B.
Source American Heart Journal 146 (2003)2. - ISSN 0002-8703 - p. 344 - 344.
Department(s) Global Nutrition
Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) acute myocardial-infarction - serum cholesteryl esters - signal-averaged electrocardiogram - physical-activity scale - sudden cardiac death - fish consumption - erythrocyte-membranes - controlled trial - cell-membranes - dietary-intake
Abstract Background - N-3 fatty acids may reduce the risk of sudden death by preventing life-threatening cardiac arrhythmias. Heart rate variability (HRV) and baroreflex sensitivity (BRS) reflect cardiac autonomic regulation; reduced values predict arrhythmic events and mortality. Effects of n-3 fatty acids on these risk indicators of arrhythmia have not been widely studied. We investigated the effect of supplemental intake of n-3 fatty acids on HRV and BRS in apparently healthy subjects aged 50 to 70 years. Methods - After a run-in period of 4 weeks, 84 subjects were randomized to receive capsules with either 3.5 g of fish oil or placebo oil daily for 12 weeks. Before and after intervention, electrocardiograms and blood pressure were recorded for 10 minutes with standardized respiration of 15 breaths/min. The SD of the duration of all normal RR intervals (SDNN10) and the root mean square successive differences (RMSSD10) were calculated from the 10-minute recordings. We also computed low frequency power (LF) and high frequency power (HF). BRS was computed by integrating the spectral systolic blood pressure to interbeat-interval transfer function in the 0.05- to 0.15-Hz band. Results - The different measures of HRV and BRS did not significantly improve with the intake of n-3 fatty acids. SDNN10 decreased by 3.05 ms or 7.7% (95% CI, -8.91-2.82 ms), and BRS decreased by 0.92 ms/mm Hg or 0.1% (95% CI, -2.66-0.81 ms/mm Hg) in the fish oil group compared with the placebo group. Conclusions - N-3 fatty acids have no effect on HRV from short-term recordings and BRS in apparently healthy subjects.
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