Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 326233
Title Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans
Author(s) Olthof, M.R.; Hollman, P.C.H.; Buijsman, M.N.C.P.; Amelsvoort, J.M.M. van; Katan, M.B.
Source The Journal of Nutrition 133 (2003)6. - ISSN 0022-3166 - p. 1806 - 1814.
DOI https://doi.org/10.1093/jn/133.6.1806
Department(s) Global Nutrition
RIKILT - Business Unit Safety & Health
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) potentially anticarcinogenic flavonoids - caffeic acid - human plasma - derivatives - quercetin - bioavailability - consumption - microflora - catechins - lithium
Abstract Dietary phenols are antioxidants, and their consumption might contribute to the prevention of cardiovascular disease. Coffee and tea are major dietary sources of phenols. Dietary phenols are metabolized extensively in the body. Lack of quantitative data on their metabolites hinders a proper evaluation of the potential biological effects of dietary phenols in vivo. The aim of this study was to identify and quantify the phenolic acid metabolites of chlorogenic acid (major phenol in coffee), quercetin-3-rutinoside (major flavonol in tea) and black tea phenols in humans, and determine the site, of metabolism. Healthy humans (n = 20) with an intact colon participated in a dietary controlled crossover study, and we identified and quantified similar to60 potential phenolic acid metabolites in urine. Half of the ingested chlorogenic acid and 43% of the tea phenols were metabolized to hippuric acid. Quercetin-3-rutinoside was metabolized mainly to phenylacetic acids, i.e., 3-hydroxyphenylacetic acid (36%), 3-methoxy-4-hydroxyphenylacetic acid (8%) and 3,4-dihydroxyphenylacetic acid (5%). In contrast, in seven humans without a colon, we found only traces of phenolic acid metabolites in urine after they had ingested chlorogenic acid and quercetin-3-rutinoside. This implies that the colonic microflora convert most of these dietary phenols into metabolites that then reach the circulation. Metabolites of dietary phenols have lower antioxidant activity than their parent compounds; therefore, the contribution of dietary phenols to antioxidant activity in vivo might be lower than expected from in vitro tests. J. Nutr. 133: 1806-1814, 2003.
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