Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 327008
Title An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi
Author(s) Cohen, G.; Barbe, V.; Flament, D.; Galperin, M.; Heilig, R.; Lecompte, O.; Prieur, D.; Poch, O.; Querellou, J.; Thierry, J.C.; Oost, J. van der; Weissenbach, J.; Zivanovic, Y.; Forterre, P.
Source Molecular Microbiology 47 (2003). - ISSN 0950-382X - p. 1495 - 1512.
DOI https://doi.org/10.1046/j.1365-2958.2003.03381.x
Department(s) Microbiology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) horizontal gene exchange - transfer-rna synthetase - replication factor-c - bacterial hyperthermophiles - hydrothermal vent - dna-polymerases - phylogenetic characterization - biochemical-characterization - thermus-thermophilus - transcription factor
Abstract The hyperthermophilic euryarchaeon Pyrococcus abyssi and the related species Pyrococcus furiosus and Pyrococcus horikoshii , whose genomes have been completely sequenced, are presently used as model organisms in different laboratories to study archaeal DNA replication and gene expression and to develop genetic tools for hyperthermophiles. We have performed an extensive re-annotation of the genome of P. abyssi to obtain an integrated view of its phylogeny, molecular biology and physiology. Many new functions are predicted for both informational and operational proteins. Moreover, several candidate genes have been identified that might encode missing links in key metabolic pathways, some of which have unique biochemical features. The great majority of Pyrococcus proteins are typical archaeal proteins and their phylogenetic pattern agrees with its position near the root of the archaeal tree. However, proteins probably from bacterial origin, including some from mesophilic bacteria, are also present in the P. abyssi genome.
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